Results 21 to 30 of about 417,177 (325)

Effect of Bmi1 over-expression on gene expression in adult and embryonic murine neural stem cells

open access: yesScientific Reports, 2018
The ability of isolated neural stem cells (NSCs) to proliferate as neurospheres is indicative of their competence as stem cells, and depends critically on the polycomb group (PcG) member Bmi1: knockdown of Bmi1 results in defective proliferation and self-
Mythily Ganapathi   +6 more
doaj   +1 more source

Enhanced derivation of human pluripotent stem cell-derived cortical glutamatergic neurons by a small molecule

open access: yesScientific Reports, 2017
Human pluripotent stem cells (hPSCs) play important role in studying the function of human glutamatergic neurons and related disease pathogenesis. However, the current hPSC-derived cortical system produced a significant number of inhibitory GABAergic ...
Shi-Ying Cao   +8 more
doaj   +1 more source

The emerging roles of ribosome biogenesis in craniofacial development. [PDF]

open access: yes, 2014
Neural crest cells (NCCs) are a transient, migratory cell population, which originates during neurulation at the neural folds and contributes to the majority of tissues, including the mesenchymal structures of the craniofacial skeleton.
Ross, Adam P, Zarbalis, Konstantinos S
core   +2 more sources

Neural Stem Cells and Glioblastoma [PDF]

open access: yesThe Neuroradiology Journal, 2014
Glioblastoma multiforme represents one of the most common brain cancers with a rather heterogeneous cellular composition, as indicated by the term “multiforme“. Recent reports have described the isolation and identification of cancer neural stem cells from human adult glioblastoma multiforme, which possess the capacity to establish, sustain, and ...
Rossella Rispoli   +4 more
openaire   +3 more sources

Altered striatal dopamine levels in Parkinson’s disease VPS35 D620N mutant transgenic aged mice

open access: yesMolecular Brain, 2020
Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that mediates the retrograde transport of cargo proteins from endosomes to the trans-Golgi network.
Sarivin Vanan   +13 more
doaj   +1 more source

Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival [PDF]

open access: yes, 2006
There are two types of neural stem cells (NSCs). Primitive NSCs [leukemia inhibitory factor (LIF) dependent but exogenous fibroblast growth factor (FGF) 2 independent] can be derived from mouse embryonic stem (ES) cells in vitro and from embryonic day 5 ...
Chaddah, R   +7 more
core   +3 more sources

The Developmental Stage of Adult Human Stem Cell-Derived Retinal Pigment Epithelium Cells Influences Transplant Efficacy for Vision Rescue

open access: yesStem Cell Reports, 2017
Age-related macular degeneration (AMD) is a common cause of central visual loss in the elderly. Retinal pigment epithelial (RPE) cell loss occurs early in the course of AMD and RPE cell transplantation holds promise to slow disease progression. We report
Richard J. Davis   +18 more
doaj   +1 more source

First steps to define murine amniotic fluid stem cell microenvironment [PDF]

open access: yes, 2016
Stem cell niche refers to the microenvironment where stem cells reside in living organisms. Several elements define the niche and regulate stem cell characteristics, such as stromal support cells, gap junctions, soluble factors, extracellular matrix ...
Bertin, Enrica   +11 more
core   +3 more sources

Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]

open access: yes, 2018
Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita   +6 more
core   +3 more sources

The stem cells of the neural crest [PDF]

open access: yesCell Cycle, 2008
In the vertebrate embryo, the neurectodermal neural crest cells (NCC) have remarkably broad potencies, giving rise, after a migratory phase, to neurons and glial cells in the peripheral nervous system, and to skin melanocytes, being all designated here as "neural" derivatives.
Nicole M. Le Douarin   +2 more
openaire   +3 more sources

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