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NPTX1 Regulates Neural Lineage Specification from Human Pluripotent Stem Cells
Neural induction is the first fundamental step in nervous system formation. During development, a tightly regulated niche modulates transient extracellular signals to influence neural lineage commitment.
Nathan C. Boles+9 more
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The emerging roles of ribosome biogenesis in craniofacial development. [PDF]
Neural crest cells (NCCs) are a transient, migratory cell population, which originates during neurulation at the neural folds and contributes to the majority of tissues, including the mesenchymal structures of the craniofacial skeleton.
Ross, Adam P, Zarbalis, Konstantinos S
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Evaluation of Dynamic Cell Processes and Behavior Using Video Bioinformatics Tools [PDF]
Just as body language can reveal a person’s state of well-being, dynamic changes in cell behavior and morphology can be used to monitor processes in cultured cells.
A Valavanidis+35 more
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Effect of Bmi1 over-expression on gene expression in adult and embryonic murine neural stem cells
The ability of isolated neural stem cells (NSCs) to proliferate as neurospheres is indicative of their competence as stem cells, and depends critically on the polycomb group (PcG) member Bmi1: knockdown of Bmi1 results in defective proliferation and self-
Mythily Ganapathi+6 more
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Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival [PDF]
There are two types of neural stem cells (NSCs). Primitive NSCs [leukemia inhibitory factor (LIF) dependent but exogenous fibroblast growth factor (FGF) 2 independent] can be derived from mouse embryonic stem (ES) cells in vitro and from embryonic day 5 ...
Chaddah, R+7 more
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Human pluripotent stem cells (hPSCs) play important role in studying the function of human glutamatergic neurons and related disease pathogenesis. However, the current hPSC-derived cortical system produced a significant number of inhibitory GABAergic ...
Shi-Ying Cao+8 more
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Neural Stem Cells and Glioblastoma [PDF]
Glioblastoma multiforme represents one of the most common brain cancers with a rather heterogeneous cellular composition, as indicated by the term “multiforme“. Recent reports have described the isolation and identification of cancer neural stem cells from human adult glioblastoma multiforme, which possess the capacity to establish, sustain, and ...
Rossella Rispoli+4 more
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An efficient platform for astrocyte differentiation from human induced pluripotent stem cells [PDF]
Summary: Growing evidence implicates the importance of glia, particularly astrocytes, in neurological and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation of highly pure populations of replicative astrocytes from ...
Abdelaal, Rawan+13 more
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Abstract‘Human neural stem cells’ jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research, is the first guideline for human neural stem cells (hNSCs) in China. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packaging requirements ...
Yu‐Kai Wang+30 more
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Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis. [PDF]
Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells, melanocytes, and peripheral neurons and glia during embryonic ...
Hao, Hongyan+4 more
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