Results 91 to 100 of about 430,196 (291)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Adult neural stem cells: The promise of the future

Neuropsychiatric Disease and Treatment, 2007
Philippe TaupinNational Neuroscience Institute, National University of SingaporeAbstract: Stem cells are self-renewing undifferentiated cells that give rise to multiple types of specialized cells of the body. In the adult, stem cells are multipotents and
Philippe Taupin
doaj  

Mitochondrial Stress Response in Neural Stem Cells Exposed to Electronic Cigarettes. [PDF]

, 2019
Stem cells provide a sensitive model to study exposure to toxicants, such as cigarette smoke. Electronic cigarettes (ECs) are popular nicotine delivery devices, often targeted to youth and pregnant mothers. However, little is known about how chemicals in
Chaili, Angela, Leung, Sara, Omaiye, Esther, Phandthong, Rattapol, Talbot, Prue, Zahedi, Atena   +5 more
core  

Differentiation of Human Embryonic Stem Cells to Sympathetic Neurons: A Potential Model for Understanding Neuroblastoma Pathogenesis [PDF]

, 2018
Background and Aims: Previous studies modelling human neural crest differentiation from stem cells have resulted in a low yield of sympathetic neurons.
Carr-Wilkinson, Jane, Deepali, Pal, Forgham, Helen, Herbert, Mary, James, Peter, Lako, Majlinda, Lee, Natalie, Moad, Mohammad, Prathalingam, Nilendran, Sundaresh, Aishwarya, Tweddle, Deborah A   +10 more
core   +4 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Emerging strategies for nerve repair and regeneration in ischemic stroke: neural stem cell therapy

Neural Regeneration Research
Ischemic stroke is a major cause of mortality and disability worldwide, with limited treatment options available in clinical practice. The emergence of stem cell therapy has provided new hope to the field of stroke treatment via the restoration of brain ...
Siji Wang, Qianyan He, Yang Qu, Wenjing Yin, Ruoyu Zhao, Xuyutian Wang, Yi Yang, Zhen-Ni Guo   +7 more
doaj   +1 more source

Evaluation of Dynamic Cell Processes and Behavior Using Video Bioinformatics Tools [PDF]

, 2015
Just as body language can reveal a person’s state of well-being, dynamic changes in cell behavior and morphology can be used to monitor processes in cultured cells.
A Valavanidis, BE Lehnert, C Ballestrem, C Carlson, C Gieseke, CC Wong, DA Drechsel, DR Albrecht, E Hinchcliffe, F Li, G DiCarlantonio, G Schatten, GG Martin, K Riveles, K Riveles, K Riveles, K Riveles, KL Tsai, M Knoll, M Knoll, M Williams, P Talbot, P Talbot, P Talbot, RZ Behar, RZ Behar, S Inoué, S Lin, S Lin, S Lin, T Haraguchi, T Ichikawa, V Adler, V Bahl, VJ Thannickal, Y Wang   +35 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells [PDF]

, 2017
Glioblastoma cells with stem-like properties control brain tumour growth and recurrence. Here, we show that endogenous neural precursor cells perform an anti-tumour response by specifically targeting stem-like brain tumour cells.
Besser, Daniel, Campos, Benito, Chirasani, Sridhar Reddy, Glass, Rainer, Graf, Daniel, Herold-Mende, Christel, Herrmann, Ilaria M., Kettenmann, Helmut, Mitsiadis, Thimios, Momma, Stefan, Sternjak, Alexander, Synowitz, Michael, Wend, Peter   +12 more
core  

Spatiomechanical Modulation of EphB4-Ephrin-B2 Signaling in Neural Stem Cell Differentiation. [PDF]

, 2018
Interactions between EphB4 receptor tyrosine kinases and their membrane-bound ephrin-B2 ligands on apposed cells play a regulatory role in neural stem cell differentiation.
Chung, Jean, Dong, Meimei, Groves, Jay, Lee, Young, SCHAFFER, David, Spelke, Dawn, Yu, Cheng-Han   +6 more
core   +2 more sources