Results 131 to 140 of about 2,117,343 (256)

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Disorder of sexual development, urinary bladder duplication, pancake kidney and neural tube defect. [PDF]

Radiol Case Rep, 2023
Dineva S, Gaydarski L, Landzhov B.
europepmc   +1 more source

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source

Polymorphisms in Maternal Selected Folate Metabolism-Related Genes in Neural Tube Defect-Affected Pregnancy. [PDF]

Adv Biomed Res, 2023
Dewelle WK, Melka DS, Aklilu AT, Gebremariam MY, Alemayehu MA, Alemayehu DH, Woldemichael TS, Gebre SG.   +7 more
europepmc   +1 more source

Youngstown Sheet and Tube representatives

, 1920
James A. Campbell, located on the bottom row, sixth from the left, poses with other executives of the Youngstown Sheet and Tube Company in Youngstown, Ohio, ca. 1920-1929. An entrepreneur at heart, Campbell was a successful businessman prior to founding
Youngstown Sheet and Tube Company
core  

Deep‐Learning‐Driven High‐Fidelity In Vivo Hyperspectral Fluorescence Imaging Under Extreme Photon‐Limited Conditions

Advanced Science, EarlyView.
Highly overlapping fluorescent signals become distinguishable in photon‐limited living organisms via advanced imaging with intelligent reconstruction. The resulting in vivo hyperspectral imaging capability reveals nanoplastic uptake and circulation in live zebrafish, providing a new approach for studying complex biological and environmental processes ...
Renjian Li, Shutao Wu, Kaixiang Li, Zhenyu An, Yuwen Ben, Guiye LI, Sunil Kumar, James Mcginty, Tawfique Hasan, Songnian Fu, Meng Zhang, LingLing Chen   +11 more
wiley   +1 more source

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Youngstown Sheet and Tube Company's South Chicago Works

, 1920
The blast furnaces at Youngstown Sheet and Tube Company's South Chicago Works in Chicago, Illinois, ca. 1920-1929. James A. Campbell's success in steel manufacturing was not limited to the Youngstown regional area.
Youngstown Sheet and Tube Company
core  

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

Eph and Ephrin Variants in Malaysian Neural Tube Defect Families. [PDF]

Genes (Basel), 2022
Mohd-Zin SW, Tan ACW, Atroosh WM, Thong MK, Azizi AB, Greene NDE, Abdul-Aziz NM.   +6 more
europepmc   +1 more source