Results 1 to 10 of about 2,001,908 (203)

Fate Specification of Neural Plate Border by Canonical Wnt Signaling and Grhl3 is Crucial for Neural Tube Closure [PDF]

EBioMedicine, 2015
During primary neurulation, the separation of a single-layered ectodermal sheet into the surface ectoderm (SE) and neural tube specifies SE and neural ectoderm (NE) cell fates.
Chiharu Kimura-Yoshida, Kyoko Mochida, Kristina Ellwanger, Christof Niehrs, Isao Matsuo   +4 more
doaj   +4 more sources

Somitic mesoderm morphogenesis is necessary for neural tube closure during Xenopus development

Frontiers in Cell and Developmental Biology, 2023
Neural tube closure is a fundamental process during vertebrate embryogenesis, which leads to the formation of the central nervous system. Defective neural tube closure leads to neural tube defects which are some of the most common human birth defects ...
Neophytos Christodoulou, Paris A. Skourides   +1 more
doaj   +3 more sources

Glycolytic activity is required for the onset of neural plate folding during neural tube closure in mouse embryos

Frontiers in Cell and Developmental Biology, 2023
Physiological hypoxia is critical for placental mammalian development. However, the underlying mechanisms by which hypoxia regulates embryonic development remain unclear.
Daisuke Sakai, Yuki Murakami, Daichi Shigeta, Mitsuhiro Tomosugi, Hiromi Sakata-Haga, Toshihisa Hatta, Hiroki Shoji   +6 more
doaj   +3 more sources

Pax3/7 regulates neural tube closure and patterning in a non-vertebrate chordate

Frontiers in Cell and Developmental Biology, 2022
Pax3/7 factors play numerous roles in the development of the dorsal nervous system of vertebrates. From specifying neural crest at the neural plate borders, to regulating neural tube closure and patterning of the resulting neural tube.
Kwantae Kim, Jameson Orvis, Alberto Stolfi   +2 more
doaj   +3 more sources

A computational dynamic systems model for in silico prediction of neural tube closure defects

Current Research in Toxicology
Neural tube closure is a critical morphogenetic event during early vertebrate development. This complex process is susceptible to perturbation by genetic errors and chemical disruption, which can induce severe neural tube defects (NTDs) such as spina ...
Job H. Berkhout, James A. Glazier, Aldert H. Piersma, Julio M. Belmonte, Juliette Legler, Richard M. Spencer, Thomas B. Knudsen, Harm J. Heusinkveld   +7 more
doaj   +3 more sources

Global analysis of cell behavior and protein dynamics reveals region-specific roles for Shroom3 and N-cadherin during neural tube closure

eLife, 2022
Failures of neural tube closure are common and serious birth defects, yet we have a poor understanding of the interaction of genetics and cell biology during neural tube closure.
Austin T Baldwin, Juliana H Kim, Hyemin Seo, John B Wallingford   +3 more
doaj   +1 more source

Thoracic and lumbar multiple neural tube defects with post repair hydrocephalus: A case report and literature review

Interdisciplinary Neurosurgery, 2023
Background: Neural tube defects are among the most common congenital anomalies, particularly in developing countries owing to significant folic acid deficiency. Nevertheless, multiple-site open neural tube defects are extremely rare.
Eyerusalem Bergene, Merhawi Leake, Yibeltal Zewdu, Abdulaziz Abdellah   +3 more
doaj   +1 more source

Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling

Nature Communications, 2023
Apical constriction is known to be critical for neural tube closure, but the signals that induce this process have not been fully characterized. Here Yoon et al.
Jaeho Yoon, Jian Sun, Moonsup Lee, Yoo-Seok Hwang, Ira O. Daar   +4 more
doaj   +1 more source

Endoplasmic reticulum stress-related calcium imbalance plays an important role on Zinc oxide nanoparticles-induced failure of neural tube closure during embryogenesis

Environment International, 2021
Zinc oxide nanoparticles (ZnO NPs) have been increasingly and widely utilized in various fields, such as agriculture, food and cosmetics. However, various levels of adverse impacts of ZnO NPs on the ecological environment and public health have been ...
Yu Yan, Guang Wang, Xin Luo, Ping Zhang, Shuang Peng, Xin Cheng, Mengwei Wang, Xuesong Yang   +7 more
doaj   +1 more source

Morphological phenotyping after mouse whole embryo culture

Frontiers in Cell and Developmental Biology, 2023
Morphological phenotyping of the mouse embryo is described at neurulation stages, primarily as a guide to evaluating the outcome of whole embryo cultures between embryonic days 8.5 and 9.5.
Andrew J. Copp, Maryam Clark, Nicholas D. E. Greene   +2 more
doaj   +1 more source