Results 11 to 20 of about 2,001,908 (203)

Neural Tube Defects: Non-Closure V. Early Closure

Pediatric Neurology Briefs, 1988
Non-closure of open neural tube defects above L2 in 105 infants born between 1978 and 1985 resulted in a significantly lower incidence (p < 0.001) of hydocephalus, shunt insertions, and ventriculitis during the first few months of life, and mortality was
J Gordon Millichap
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Apoptosis is not required for mammalian neural tube closure [PDF]

, 2009
Apoptotic cell death occurs in many tissues during embryonic development and appears to be essential for processes including digit formation and cardiac outflow tract remodeling. Studies in the chick suggest a requirement for apoptosis during neurulation,
Massa V, Flavell R, Savery D, Cecconi F, Greene ND, Rongvaux A, Copp AJ., Ferraro E, Ybot-Gonzalez P   +8 more
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Folate deficiency induced H2A ubiquitination to lead to downregulated expression of genes involved in neural tube defects

Epigenetics & Chromatin, 2019
Background Neural tube defects (NTDs) are common congenital malformations resulting in failure of the neural tube closure during early embryonic development.
Pei Pei, Xiyue cheng, Juan Yu, Jinying Shen, Xue Li, Jianxin Wu, Shan Wang, Ting Zhang   +7 more
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A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure

Disease Models & Mechanisms, 2016
Genetic variations affecting neural tube closure along the head result in malformations of the face and brain. Neural tube defects (NTDs) are among the most common birth defects in humans.
Keith S. K. Fong, Robert B. Hufnagel, Vedbar S. Khadka, Michael J. Corley, Alika K. Maunakea, Ben Fogelgren, Zubair M. Ahmed, Scott Lozanoff   +7 more
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Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure

Cell Reports, 2017
Summary: Abnormal folate one-carbon metabolism (FOCM) is implicated in neural tube defects (NTDs), severe malformations of the nervous system. MTHFR mediates unidirectional transfer of methyl groups from the folate cycle to the methionine cycle and ...
Kit-Yi Leung, Yun Jin Pai, Qiuying Chen, Chloe Santos, Enrica Calvani, Sonia Sudiwala, Dawn Savery, Markus Ralser, Steven S. Gross, Andrew J. Copp, Nicholas D.E. Greene   +10 more
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Abnormal skull findings in neural tube defects [PDF]

, 2009
The human neural tube develops and closes during the third and fourth week after conception and is normally completed by 28 days post-conception. Malformations, knows as neural tube defects, occure, when the normal closure process fails. Several clinical
Cacciatore , Alessandro, Carrara, Sabina, Rapisarda, Giulia, La Galia, Tindara, Recupero , Stefania, Mammaro, Alessia, Accardi, Manuela Chiara, Pedata, Rosa, Imbruglia, Laura, Pappalardo, Elisa Maria   +9 more
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A Novel Occulta-Type Spina Bifida Mediated by Murine Double Heterozygotes EphA2 and EphA4 Receptor Tyrosine Kinases

Frontiers in Cell and Developmental Biology, 2017
Members of the Eph receptor tyrosine kinase have previously been implicated in cranial neural tube development. Failure of neural tube closure leads to the devastating conditions known as anencephaly and spina bifida. EphA2 and EphA4 are expressed at the
Nor Linda Abdullah, Siti W. Mohd-Zin, Azlina Ahmad-Annuar, Noraishah M. Abdul-Aziz   +3 more
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A case report of triple neural tube defect: revisiting the multisite closure theory

BMC Surgery, 2019
Background Triple neural tube defects are rare. To the author’s knowledge, there are only four reported cases available in the literature up to date. Controversies exist with regards to the development of neural tube defects.
Jayant Kumar Yadav, Ahtesham Khizar, Pradhumna Kumar Yadav, Ghulam Mustafa, Sajid Nazir Bhatti   +4 more
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Pax3 stimulates p53 ubiquitination and degradation independent of transcription. [PDF]

PLoS ONE, 2011
Pax3 is a developmental transcription factor that is required for neural tube and neural crest development. We previously showed that inactivating the p53 tumor suppressor protein prevents neural tube and cardiac neural crest defects in Pax3-mutant mouse
Xiao Dan Wang, Sarah C Morgan, Mary R Loeken   +2 more
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Cilia and their role in neural tube development and defects

Reproductive and Developmental Medicine, 2022
. Cilia are microtubule-based filamentous organelles that play a vital role in embryogenesis. Multiple signal transduction pathways are orchestrated by cilia, such as Hedgehog and planar cell polarity signals.
Lu Yan, Yu-Fang Zheng, Yong-Qing Zhu
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