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Correction for Shahriar et al., Targeted recruitment of immune effector cells for rapid eradication of influenza virus infections. [PDF]

Proc Natl Acad Sci U S A
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The G57 genotype of the BJ/94-like H9N2 lineage exhibits increased replication and virulence in chickens compared to the G1 Middle East Group B lineage

Bhat S, Sadeyen J, Yang J, Chrazstek K, Karunarathna TK, Qureshi M, Bialy D, Shelton H, Iqbal M.   +8 more
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Mutations of neuraminidase implicated in neuraminidase inhibitors resistance

Journal of Clinical Virology, 2008
Influenza constitutes one of the most important upper respiratory tract infections regarding morbidity, and mortality. Prevention and treatment of influenza rely on inactivated vaccines and antiviral drugs. Zanamivir and Oseltamivir, the currently available influenza neuraminidase inhibitors (NAI) can be used in clinical practice for the treatment of ...
Bruno Lina, Olivier Ferraris
openaire   +2 more sources

Impact of influenza A virus neuraminidase mutations on the stability, activity, and sensibility of the neuraminidase to neuraminidase inhibitors

Journal of Clinical Virology, 2008
The influenza neuraminidase plays a critical role in the spread of the influenza A and B viruses. Through the cleavage of terminal sialic acid from glycoconjugates, it facilitates the elution of progeny virions from infected cells and prevents their self-aggregation.Our objective was to study the impact of mutations at framework sites not under direct ...
Mathilde Richard, Alan Hay, Yi Pu Lin, Claire Deleage, Bruno Lina, Mendy Barthélémy, Olivier Ferraris   +6 more
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Neuraminidase and tumor immunotherapy

Klinische Wochenschrift, 1977
Preliminary results of first clinical studies with the enzyme neuraminidase call attention to a new kind of cancer treatment. This promising approach to tumor immunotherapy was entered into the clinical phase as a consequence of successful experimental studies in tumor-bearing mice, rats and dogs.
H. H. Sedlacek, H. G. Schwick, F. R. Seiler   +2 more
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Mitogenic action of neuraminidase

Experientia, 1977
A new effect of NCV on lymphocytes is demonstrated. This property is the capacity to act as a mitogen in and of itself. The possible mechanisms of this phenomenon are discussed.
SEMENZATO, GIANPIETRO CARLO, Sarasin P, AMADORI, GIUSEPPE, GASPAROTTO, GIUSEPPE   +3 more
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Neuraminidase and Anti‐Neuraminidase Serum: Effect on the Cell Surface Properties

Vox Sanguinis, 1973
Abstract. Neuraminidase lowers the electrical cell surface charge by cleavage of N‐acetylneuraminic acid (NANA) from the cell periphery. Neuraminidase antisera prepared in rabbits increase the surface charge density of neuraminidase‐treated cells. It is suggested that the lowering of the cell surface charge is due not only to enzymatic splitting of ...
P. Sachtleben, R. Gsell, J. N. Mehrishi
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