Results 91 to 100 of about 87,065 (293)

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Enhanced Neurite Outgrowth by Intracellular Stimulation

Nano Letters, 2015
Electrical stimulation through direct electrical activation has been widely used to recover the function of neurons, primarily through the extracellular application of thin film electrodes. However, studies using extracellular methods show limited ability to reveal correlations between the cells and the electrical stimulation due to interference from ...
Ilsoo, Kim, Hye Yeong, Lee, Hyungsuk, Kim, Eungjang, Lee, Du-Won, Jeong, Ju-Jin, Kim, Seung-Han, Park, Yoon, Ha, Jukwan, Na, Youngcheol, Chae, Seong, Yi, Heon-Jin, Choi   +11 more
openaire   +3 more sources

Live neuron images for neurite outgrowth.

, 2013
Note that SCF+G-CSF treatment leads to a marked increase in neurite extension, and that NFκB inhibitor, BAY 11-7082, prevents the SCF+G-CSF-induced the enhancement of neurite outgrowth.
Bin Li (39349), Lili Cui (418196), Chunshu Piao (314392), Ye Su (179577), Li-Ru Zhao (315745)   +4 more
core   +1 more source

Magnetoelectric Nanoparticle‐Based Wireless Brain–Computer Interface: Underlying Physics and Projected Technology Pathway

Advanced Science, EarlyView.
Magnetoelectric nanoparticles (MENPs) enable fully wireless, minutely invasive neuromodulation, and potentially neural recording, by converting magnetic into electric and, conversely, electric into magnetic fields, respectively, at high spatiotemporal resolution.
Elric Zhang, Max Shotbolt, Mostafa Abdel‐Mottaleb, Shawnus Chen, Victoria Andre, Jieyuan Tian, Jonathan Shulgach, Max Murphy, Brian Noga, Ping Liang, Darcy Griffin, Douglas Weber, Marta Pardo, Salvador Pane, Sakhrat Khizroev   +14 more
wiley   +1 more source

E46K α-Synuclein Mutation Fails to Promote Neurite Outgrowth by Not Inducing Cdc42EP2 Expression, Unlike Wild-Type or A53T α-Synuclein in SK-N-SH Cells

Brain Sciences
Background/Objectives: α-Synuclein (α-syn) protein is a major pathological agent of familial Parkinson’s disease (PD), and its levels and aggregations determine neurotoxicity in PD pathogenesis.
Hyunja Jung, Seonghan Kim
doaj   +1 more source

Contrast bath-induced neurite outgrowth in PC12m3 cells via the p38 mitogen-activated protein kinase pathway

Heliyon, 2019
We investigated the differentiation and activation of p38 MAPK induced by contrast bath in drug-hypersensitive PC12m3 mutant cells. The rate of neurite outgrowth in PC12m3 cells induced by contrast bath was much higher than that induced by warming or ...
Hirotoshio Motoda, Fukumi Hiragami, Kenji Kawamura, Shigeki Inoue, Yutaka Gomita, Yoshio Kano   +5 more
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Neurite outgrowth on a fibronectin isoform expressed during peripheral nerve regeneration is mediated by the interaction of paxillin with α4β1 integrins

BMC Neuroscience, 2007
Background The regeneration of peripheral nerve is associated with a change in the alternative splicing of the fibronectin primary gene transcript to re-express embryonic isoforms containing a binding site for α4β1 integrins that promote neurite ...
Ginsberg Mark H, Han Jaewon, Forster Ulrike B, Vogelezang Mariette, ffrench-Constant Charles   +4 more
doaj   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Golgi-resident TRIO regulates membrane trafficking during neurite outgrowth. [PDF]

, 2019
Neurite outgrowth requires coordinated cytoskeletal rearrangements in the growth cone and directional membrane delivery from the neuronal soma. As an essential Rho guanine nucleotide exchange factor (GEF), TRIO is necessary for cytoskeletal dynamics ...
Zhao, Wei, Zheng, Yan-Yan, Wang, Wei, Tao, Tao, Li, Yeqiong, Zhou, Yuwei, Sun, Jie, Liu, Jianghuai, Chen, Xin, Shi, Yun, Zhu, Min-Sheng, Peng, Yajing, Wang, Pei, Wei, Lisha   +13 more
core   +1 more source