Results 121 to 130 of about 87,065 (293)
Shoc2/Sur8 Protein Regulates Neurite Outgrowth
PLoS ONE, 2014 The Shoc2 protein has been implicated in the positive regulation of the Ras-ERK pathway by increasing the functional binding interaction between Ras and Raf, leading to increased ERK activity. Here we found that Shoc2 overexpression induced sustained ERK phosphorylation, notably in the case of EGF stimulation, and Shoc2 knockdown inhibited ERK ...
León, Gonzalo +17 more
openaire +8 more sources
Advanced Science, EarlyView.In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao +12 more
wiley +1 more source
Uridine Promotes Neurite Outgrowth in Neuro2a Cells [PDF]
, 2019 Neurodegenerative diseases such as Alzheimer\u27s and Parkinson\u27s are the main causes of age-related dementia. These diseases can be due to neuronal cell death and/or impairment of neurite outgrowth.
Spathies, Jacquelyn
core
Advanced Science, EarlyView.Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang +12 more
wiley +1 more source
A diffusion‐based neurite length‐sensing mechanism involved in neuronal symmetry breaking
Molecular Systems Biology, 2010 Although there has been significant progress in understanding the molecular signals that change cell morphology, mechanisms that cells use to monitor their size and length to regulate their morphology remain elusive.
Michinori Toriyama +4 more
doaj +1 more source
Neural Regeneration Research, 2016 Spontaneous axonal regeneration of neurons does not occur after spinal cord injury because of inhibition by myelin and other inhibitory factors. Studies have demonstrated that blocking the Rho/Rho-kinase (ROCK) pathway can promote neurite outgrowth in ...
Xu-feng Jia +3 more
doaj +1 more source
Evaluation of neurite outgrowth stimulation and neuroprotective activities of Hericium erinaceus extracts on cell line NG 108-15 / Lai Puei-Lene [PDF]
, 2012 Neurotrophic factors play an indispensable role in the functionality and development of the nervous system. One of the well-studied neurotrophic factors is nerve growth factor (NGF), which is required for the growth and differentiation of dorsal root ...
Lai, Puei-Lene
core
Advanced Science, EarlyView.The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English +9 more
wiley +1 more source
Advanced Science, EarlyView.Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu +5 more
wiley +1 more source
Effect of the Sigma-1 receptor on neurite outgrowth [PDF]
, 2014 Neurite outgrowth is one of the essential processes underlying development and plasticity of the nervous system. Enhancing neurite outgrowth, along with neural protection, is one of the most prominent therapeutic strategies against neuronal degeneration ...
Yuriko Kimura, Yuki Fujita, Toshihide Yamashita
core +1 more source