Results 151 to 160 of about 56,568 (206)

Neurochemical Diversity of Dystrophic Neurites in the Early and Late Stages of Alzheimer's Disease

Experimental Neurology, 1999
We examined the neurochemical and morphological diversity of abnormal neurites associated with β-amyloid plaque formation in the early and late stages of Alzheimer's disease.
James Vickers, Tracey C. Dickson, Graeme H McCormack   +2 more
exaly   +1 more source

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Neurite guidance by the FnC repeat of human tenascin‐C: neurite attraction vs. neurite retention

European Journal of Neuroscience, 2005
AbstractThe alternatively spliced fibronectin type‐III repeat C of human tenascin‐C (fnC) provides directional cues to elongating neurites in vitro. When given a choice at an interface with poly l‐lysine (PLL), rat cerebellar granule neurites preferentially crossed onto fnC (defined herein as neurite attraction) whereas neurites originating on fnC ...
Hsing-Yin, Liu, Alam, Nur-E-Kamal, Melitta, Schachner, Sally, Meiners   +3 more
openaire   +2 more sources

Neurite óptica

2023
O objetivo deste capítulo é apresentar o conceito, etiologia, fisiopatologia, manifestações clínicas, diagnóstico e formas de tratamento da neurite óptica. A neurite óptica é considerada um distúrbio visual agudo e grave, no qual, dependendo da etiologia, o prognóstico visual e o risco de lesões recorrentes podem variar.
Gabriel Lopes Chaves, Gabriela Aparecida Leonel, Vitoria Kalil Rösler Silva, Lucélia Terra Chini, Isabelle Cristinne Pinto Costa, Rômulo Severo Sampaio, Conceição Terra Jonas, Érika de Cássia Lopes Chaves   +7 more
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Simple Neurite Tracer

2011
Motivation: Advances in techniques to sparsely label neurons unlock the potential to reconstruct connectivity from 3D image stacks acquired by light microscopy. We present an application for semi-automated tracing of neurons to quickly annotate noisy datasets and construct complex neuronal topologies, which we call the Simple Neurite Tracer ...
Longair, M H, Baker, D A, Armstrong, J D
openaire   +2 more sources

Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging

Neurobiology of Aging, 2009
The morphology and neurochemistry of β-amyloid (Aβ) plaque-associated dystrophic neurites present in TgCRND8 and Tg2576 mice was demonstrated to be strikingly similar to that observed in pathologically aged human cases, but not in Alzheimer’s disease (AD)
James Vickers, Adele Woodhouse, Tracey C. Dickson   +2 more
exaly   +1 more source

Mechanosensitive Channels in Neurite Outgrowth

2007
This chapter focuses on the convergence of two areas of investigation in the past: the first is the study of the molecular basis for Ca(2+)-dependent axon pathfinding, and the second is the molecular and the functional characterization of mechanosensitive Ca(2+)-permeant cation channels (MscCa). The convergence of these two fields has reached a pivotal
PELLEGRINO, MARIO, PELLEGRINI M.
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Control over Neurite Directionality and Neurite Elongation on Anisotropic Micropillar Arrays

Small, 2015
Control over neurite orientation in primary hippocampal neurons is achieved by using interrupted, anisotropic micropillar arrays as a cell culture platform. Both neurite orientation and neurite length are controlled by a function of interpillar distance.
Matthew, Park, Eunkyul, Oh, Jeongyeon, Seo, Mi-Hee, Kim, Hyeoncheol, Cho, Ji Yu, Choi, Haiwon, Lee, Insung S, Choi   +7 more
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Imaging of Neurite Network with an Anti-L1CAM Aptamer Generated by Neurite-SELEX

Journal of the American Chemical Society, 2018
Neurite outgrowth is the critical step of nervous development. Molecular probes against neurites are essential for evaluation of the nervous system development, compound neurotoxicity, and drug efficacy on nerve regeneration. To obtain a neurite probe, we developed a neurite-SELEX strategy and generated a DNA aptamer, yly12, that strongly binds ...
Linlin Wang, Tao Bing, Ying Liu, Nan Zhang, Luyao Shen, Xiangjun Liu, Junyan Wang, Dihua Shangguan   +7 more
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Cholinergic Innervation in Neuritic Plaques

Science, 1982
Although several studies of Alzheimer's disease suggest that the frequency of neuritic plaques in the cerebral cortex is correlated with the severity of dementia and with reduction in presynaptic cholinergic markers in the cortex, the relationship between cholinergic cortical innervation and the pathogenesis of plaques is unknown.
R G, Struble, L C, Cork, P J, Whitehouse, D L, Price   +3 more
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Inhibitor of neurite outgrowth in humans

Nature, 2000
Axons are generally believed to be incapable of regeneration in the adult central nervous system1,2. Inhibition results from physical barriers imposed by glial scars, a lack of neurotrophic factors, and growth-inhibitory molecules associated with myelin3,4,5, the insulating axon sheath.
R, Prinjha, S E, Moore, M, Vinson, S, Blake, R, Morrow, G, Christie, D, Michalovich, D L, Simmons, F S, Walsh   +8 more
openaire   +2 more sources