Results 1 to 10 of about 95,315 (199)

Hypoxia preconditioned serum (HPS) and platelet-rich plasma (PRP) promote proliferation, neurite network formation, and neurite elaboration in N2a cells [PDF]

Frontiers in Bioengineering and Biotechnology
BackgroundThe use of autologous growth factors, such as those contained in Hypoxia-Preconditioned Serum (HPS) and Platelet-Rich Plasma (PRP), represents a promising strategy to enhance regenerative processes in injured nerves.
Jun Jiang, Donya Safa, Samuel Knoedler, Jannat Altammar, Jannat Altammar, Florian Falkner, Florian Falkner, Marc Hanschen, Haydar Kükrek, Ulf Dornseifer, Arndt F. Schilling, Hans-Günther Machens, Philipp Moog   +12 more
doaj   +2 more sources

Physical Cues of Matrices Reeducate Nerve Cells

Frontiers in Cell and Developmental Biology, 2021
The behavior of nerve cells plays a crucial role in nerve regeneration. The mechanical, topographical, and electrical microenvironment surrounding nerve cells can activate cellular signaling pathways of mechanical transduction to affect the behavior of ...
Yiqian Luo, Jie Li, Baoqin Li, Yuanliang Xia, Hengyi Wang, Changfeng Fu   +5 more
doaj   +1 more source

Effect of GSK-3β-mediated DRP1 on inhibition of primary hippocampal neuronal growth induced by aluminum

环境与职业医学, 2022
BackgroundAluminum (Al) can cause irreversible damage to neurons and synapses function, and the mechanism may be connected to mitochondrial damage caused by glycogen synthase kinase-3β (GSK-3β) regulating dynamin-related protein 1 (DRP1), resulting in ...
Meng LI, Liyuan LU, Xiaoyu HE, Changxin XIANG, Xiaoya CAI, Huifang ZHANG   +5 more
doaj   +1 more source

Effect of aluminum-maltolate on primary hippocampal neuron neurite damage by regulating CRMP2 through GSK-3β in mice

环境与职业医学, 2021
BackgroundAluminum can induce irreversible structural and synaptic functional damage, and the associated mechanism may be related to the neurite damage regulated by glycogen synthase kinase-3β (GSK-3β)/collapsin response mediator protein 2 (CRMP2 ...
Huifang ZHANG, Yingchao HAN, Xiaoya CAI, Changxin XIANG, Qiao NIU   +4 more
doaj   +1 more source

PERFIL EPIDEMIOLÓGICO E CLÍNICO DE PACIENTES COM REAÇÃO HANSÊNICA ACOMPANHADOS EM UM HOSPITAL DE REFERÊNCIA

Revista de Ciências da Saúde Nova Esperança, 2021
A hanseníase é uma doença infecciosa, granulomatosa, de caráter crônico, causada pelo Mycobacterium leprae, que tem predileção pela pele e nervos periféricos. Alguns pacientes apresentam episódios inflamatórios, conhecidos como estado reacional ou reação
Maite de Souza e Silva, Luciana Cavalcante Trindade, Duanra Christi Queiroz Teixeira, Raul José Almeida Albuquerque, Bruna Braga Nóbrega de Holanda Barreto   +4 more
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Microglia modulate proliferation, neurite generation and differentiation of human neural progenitor cells

Frontiers in Cell and Developmental Biology, 2022
Microglia, the primary immune cells of the brain, significantly influence the fate of neurons after neural damage. Depending on the local environment, they exhibit a wide range of phenotypes, including patrolling (naïve), proinflammatory, and anti ...
Julianna Lilienberg, Julianna Lilienberg, Ágota Apáti, János M. Réthelyi, János M. Réthelyi, László Homolya   +5 more
doaj   +1 more source

Bcl-xL Is Required by Primary Hippocampal Neurons during Development to Support Local Energy Metabolism at Neurites

Biology, 2021
B-cell lymphoma-extra large (Bcl-xL) is a mitochondrial protein known to inhibit mitochondria-dependent intrinsic apoptotic pathways. An increasing number of studies have demonstrated that Bcl-xL is critical in regulating neuronal energy metabolism and ...
Joseph Jansen, Madison Scott, Emma Amjad, Allison Stumpf, Kimberly H. Lackey, Kim A. Caldwell, Han-A Park   +6 more
doaj   +1 more source

Pharmacological Modulation of Neurite Outgrowth in Human Neural Progenitor Cells by Inhibiting Non-muscle Myosin II

Frontiers in Cell and Developmental Biology, 2021
Studies on neural development and neuronal regeneration after injury are mainly based on animal models. The establishment of pluripotent stem cell (PSC) technology, however, opened new perspectives for better understanding these processes in human models
Julianna Lilienberg, Zoltán Hegyi, Eszter Szabó, Edit Hathy, András Málnási-Csizmadia, András Málnási-Csizmadia, János M. Réthelyi, János M. Réthelyi, Ágota Apáti, László Homolya   +9 more
doaj   +1 more source

RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth

Biomolecules, 2021
Diacylglycerol kinase β (DGKβ) is an enzyme that converts diacylglycerol to phosphatidic acid and is mainly expressed in the cerebral cortex, hippocampus and striatum.
Takuya Kano, Ryosuke Tsumagari, Akio Nakashima, Ushio Kikkawa, Shuji Ueda, Minoru Yamanoue, Nobuyuki Takei, Yasuhito Shirai   +7 more
doaj   +1 more source

DDHD1, but Not DDHD2, Suppresses Neurite Outgrowth in SH-SY5Y and PC12 Cells by Regulating Protein Transport From Recycling Endosomes

Frontiers in Cell and Developmental Biology, 2020
DDHD1 and DDHD2 are both intracellular phospholipases A1 and hydrolyze phosphatidic acid in vitro. Given that phosphatidic acid participates in neurite outgrowth, we examined whether DDHD1 and DDHD2 regulate neurite outgrowth.
Yuki Maemoto, Tomohiro Maruyama, Kazuaki Nemoto, Takashi Baba, Takashi Baba, Manae Motohashi, Akihiro Ito, Mitsuo Tagaya, Katsuko Tani   +8 more
doaj   +1 more source