Results 1 to 10 of about 43,460 (118)

Filamented hydrogels as tunable conduits for guiding neurite outgrowth [PDF]

Materials Today Bio
Anisotropic scaffolds with unidirectionally aligned fibers present an optimal solution for nerve tissue engineering and graft repair. This study investigates the application of filamented light (FLight) biofabrication to create hydrogel matrices ...
Hao Liu, Anna Puiggalí-Jou, Parth Chansoria, Jakub Janiak, Marcy Zenobi-Wong   +4 more
doaj   +2 more sources

Extracts from Cordyceps cicadae and Hericium erinaceus promote the neurite outgrowth of retinal ganglion cells. [PDF]

PLoS ONE
The regenerative capacity of mammalian RGC neurites after damage, such as glaucoma, is limited. Numerous studies have utilized herbal extracts to promote neural regeneration and exert neuroprotective effects in the hope of mitigating glaucoma.
Fang-Yi Chen, Chin-Chu Chen, Chuan-Chin Chiao   +2 more
doaj   +2 more sources

Nimodipine promotes neurite outgrowth and protects against neurotoxicity in PC12 cells [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Nimodipine is an L-type voltage-dependent calcium channel (VDCC) antagonist. However, the actions of nimodipine except calcium blocking are poorly understood. This study aimed to investigate the effect of nimodipine on neurite outgrowth and
Miduki Kusakabe, Yasushi Hasegawa
doaj   +1 more source

RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth

Biomolecules, 2021
Diacylglycerol kinase β (DGKβ) is an enzyme that converts diacylglycerol to phosphatidic acid and is mainly expressed in the cerebral cortex, hippocampus and striatum.
Takuya Kano, Ryosuke Tsumagari, Akio Nakashima, Ushio Kikkawa, Shuji Ueda, Minoru Yamanoue, Nobuyuki Takei, Yasuhito Shirai   +7 more
doaj   +1 more source

Uridine from Pleurotus giganteus and Its Neurite Outgrowth Stimulatory Effects with Underlying Mechanism. [PDF]

PLoS ONE, 2015
Neurodegenerative diseases are linked to neuronal cell death and impairment of neurite outgrowth. An edible mushroom, Pleurotus giganteus was found to stimulate neurite outgrowth in vitro but the chemical constituents and the underlying mechanism is yet ...
Chia-Wei Phan, Pamela David, Kah-Hui Wong, Murali Naidu, Vikineswary Sabaratnam   +4 more
doaj   +1 more source

Caesalpinia mimosoides Leaf Extract Promotes Neurite Outgrowth and Inhibits BACE1 Activity in Mutant APP-Overexpressing Neuronal Neuro2a Cells

Pharmaceuticals, 2021
Alzheimer’s disease (AD) is implicated in the imbalance of several proteins, including Amyloid-β (Aβ), amyloid precursor protein (APP), and BACE1. APP overexpression interferes with neurite outgrowth, while BACE1 plays a role in Aβ generation.
Panthakarn Rangsinth, Chatrawee Duangjan, Chanin Sillapachaiyaporn, Ciro Isidoro, Anchalee Prasansuklab, Tewin Tencomnao   +5 more
doaj   +1 more source

The lncRNA MALAT1/miR-30/Spastin Axis Regulates Hippocampal Neurite Outgrowth

Frontiers in Cellular Neuroscience, 2020
Spastin, a microtubule-severing enzyme, is important for neurite outgrowth. However, the mechanisms underlying the post-transcriptional regulation of spastin during microtubule-related processes are largely unknown.
Tao Jiang, Tao Jiang, Zhenbin Cai, Zhisheng Ji, Jianyu Zou, Zhi Liang, Guowei Zhang, Yaozhong Liang, Hongsheng Lin, Minghui Tan   +9 more
doaj   +1 more source

Targeting MicroRNA-125b Promotes Neurite Outgrowth but Represses Cell Apoptosis and Inflammation via Blocking PTGS2 and CDK5 in a FOXQ1-Dependent Way in Alzheimer Disease

Frontiers in Cellular Neuroscience, 2020
This study aimed to explore the molecular regulatory network among microRNA-125b (miR-125b), forkhead box Q1 (FOXQ1), prostaglandin-endoperoxide synthase 2 (PTGS2), and cyclin-dependent kinase 5 (CDK5), as well as their effects on cell apoptosis, neurite
Jingcong Zhuang, Jingcong Zhuang, Zhongjie Chen, Pingping Cai, Rong Wang, Qingwei Yang, Qingwei Yang, Longling Li, Huili Yang, Renjing Zhu, Renjing Zhu   +10 more
doaj   +1 more source

Na+/Ca2+ Exchanger Inhibitors Inhibit Neurite Outgrowth in PC12 Cells

Journal of Pharmacological Sciences, 2011
.: To elucidate the role of Na+/Ca2+ exchanger (NCX) in neurite outgrowth, we investigated the effects of NCX inhibitors on neurite outgrowth in PC12 cells.
Toru Oda, Toshiaki Kume, Yasuhiko Izumi, Kumatoshi Ishihara, Hachiro Sugmimoto, Akinori Akaike   +5 more
doaj   +1 more source

Far-infrared ray radiation promotes neurite outgrowth of neuron-like PC12 cells through AKT1 signaling

Journal of the Formosan Medical Association, 2019
Background/purpose: Far-infrared (FIR) therapy is a safe and noninvasive source for medical applications. Animal study has shown the effects of FIR in promoting nerve repair. However, the cellular mechanism is not well known.
Jue-Long Wang, Yong-Chong Lin, Tai-Horng Young, Min-Huey Chen   +3 more
doaj   +1 more source