Results 1 to 10 of about 11,319,078 (248)

A Ribosomal Perspective on Neuronal Local Protein Synthesis [PDF]

Frontiers in Molecular Neuroscience, 2022
Continued mRNA translation and protein production are critical for various neuronal functions. In addition to the precise sorting of proteins from cell soma to distant locations, protein synthesis allows a dynamic remodeling of the local proteome in a ...
Sudhriti Ghosh Dastidar, Deepak Nair
doaj   +3 more sources

Identifying mRNAs Residing in Myelinating Oligodendrocyte Processes as a Basis for Understanding Internode Autonomy

Life, 2023
In elaborating and maintaining myelin sheaths on multiple axons/segments, oligodendrocytes distribute translation of some proteins, including myelin basic protein (MBP), to sites of myelin sheath assembly, or MSAS.
Robert Gould, Scott Brady
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Transcriptomes of Injured Lamprey Axon Tips: Single-Cell RNA-Seq Suggests Differential Involvement of MAPK Signaling Pathways in Axon Retraction and Regeneration after Spinal Cord Injury

Cells, 2022
Axotomy in the CNS activates retrograde signals that can trigger regeneration or cell death. Whether these outcomes use different injury signals is not known.
Li-Qing Jin, Yan Zhou, Yue-Sheng Li, Guixin Zhang, Jianli Hu, Michael E. Selzer   +5 more
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The Role of RNA Binding Proteins for Local mRNA Translation: Implications in Neurological Disorders

Frontiers in Molecular Biosciences, 2020
As neurons are one of the most highly polarized cells in our body, they require sophisticated cellular mechanisms to maintain protein homeostasis in their subcellular compartments such as axons and dendrites.
Maximilian Paul Thelen, Min Jeong Kye
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RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons

Cells, 2021
Cell polarity is crucial for almost every cell in our body to establish distinct structural and functional domains. Polarized cells have an asymmetrical morphology and therefore their proteins need to be asymmetrically distributed to support their ...
Maite Blanco-Urrejola, Adhara Gaminde-Blasco, María Gamarra, Aida de la Cruz, Elena Vecino, Elena Alberdi, Jimena Baleriola   +6 more
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Selective targeting of mRNA and the following protein synthesis of CaMKIIα at the long-term potentiation-induced site

Biology Open, 2020
Late-phase long-term potentiation (L-LTP) in hippocampus, thought to be the cellular basis of long-term memory, requires new protein synthesis. Neural activity enhances local protein synthesis in dendrites, which in turn mediates long-lasting synaptic ...
Itsuko Nihonmatsu, Noriaki Ohkawa, Yoshito Saitoh, Reiko Okubo-Suzuki, Kaoru Inokuchi   +4 more
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Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons

eLife, 2019
Extrinsic cues trigger the local translation of specific mRNAs in growing axons via cell surface receptors. The coupling of ribosomes to receptors has been proposed as a mechanism linking signals to local translation but it is not known how broadly this ...
Max Koppers, Roberta Cagnetta, Toshiaki Shigeoka, Lucia CS Wunderlich, Pedro Vallejo-Ramirez, Julie Qiaojin Lin, Sixian Zhao, Maximilian AH Jakobs, Asha Dwivedy, Michael S Minett, Anaïs Bellon, Clemens F Kaminski, William A Harris, John G Flanagan, Christine E Holt   +14 more
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Axon-glia interaction and membrane traffic in myelin formation

Frontiers in Cellular Neuroscience, 2014
In vertebrate nervous systems myelination of neuronal axons has evolved to increase conduction velocity of electrical impulses with minimal space and energy requirements.
Robin eWhite, Eva-Maria eKrämer-Albers
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Fragile X mental retardation protein is involved in protein synthesis-dependent collapse of growth cones induced by Semaphorin-3A

Frontiers in Neural Circuits, 2009
Fragile X syndrome, the most frequent form of familial mental retardation, is caused by mutation of the Fmr1 gene. Fmr1 encodes the Fragile X Mental Retardation Protein (FMRP), an mRNA binding protein regulating local, postsynaptic mRNA translation ...
Chanxia Li, Gary j Bassell, Gary j Bassell, Yukio Sasaki   +3 more
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Object-Based Analyses in FIJI/ImageJ to Measure Local RNA Translation Sites in Neurites in Response to Aβ1-42 Oligomers

Frontiers in Neuroscience, 2020
Subcellular protein delivery is especially important in signal transduction and cell behavior, and is typically achieved by localization signals within the protein.
María Gamarra, María Gamarra, Maite Blanco-Urrejola, Maite Blanco-Urrejola, Maite Blanco-Urrejola, Andreia F. R. Batista, Andreia F. R. Batista, Andreia F. R. Batista, Josune Imaz, Jimena Baleriola, Jimena Baleriola, Jimena Baleriola   +11 more
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