Results 31 to 40 of about 11,319,078 (248)

Effect of high glucose concentration on the synthesis of monocyte chemoattractant protein-1 in human peritoneal mesothelial cells: Involvement of protein kinase C [PDF]

, 2001
Human peritoneal mesothelial cells (HMC) contribute to the activation and control of inflammatory processes in the peritoneum by their potential to produce various inflammatory mediators.
Lederer, Stephan R., Sitter, Thomas, Sellmayer, Alois, Mandl-Weber, Sonja, Haslinger, Bettina, Alois Sellmayer, Bettina Haslinger, Sonja Mandl-Weber, Thomas Sitter, Stephan R. Lederer   +9 more
core   +1 more source

The relationship between dendritic branch dynamics and CPEB-labeled RNP granules captured in vivo

Frontiers in Neural Circuits, 2009
Cytoplasmic Polyadenylation Element Binding protein (CPEB) is an RNA binding protein involved in dendritic delivery of mRNA and activity-dependent, polyadenylation-induced translation of mRNAs in the dendritic arbor.
Jennifer E Bestman, Hollis Cline
doaj   +1 more source

Cystatin B Involvement in Synapse Physiology of Rodent Brains and Human Cerebral Organoids

Frontiers in Molecular Neuroscience, 2019
Cystatin B (CSTB) is a ubiquitous protein belonging to a superfamily of protease inhibitors. CSTB may play a critical role in brain physiology because its mutations cause progressive myoclonic epilepsy-1A (EPM1A), the most common form of progressive ...
Eduardo Penna, Angela Cerciello, Angela Chambery, Rosita Russo, Filippo M. Cernilogar, Emilia Maria Pedone, Carla Perrone-Capano, Carla Perrone-Capano, Silvia Cappello, Rossella Di Giaimo, Rossella Di Giaimo, Marianna Crispino   +11 more
doaj   +1 more source

Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis [PDF]

, 2009
Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177.
Boyd, Alasdair R., Stuart A. Ritchie, Ian P. Salt, Salt, Ian P., Kohlhaas, Christine F, Yalla, Krishna C, Kohlhaas, Christine F., Boyd, Alasdair R, Krishna C. Yalla, Walsh, Kenneth, Ritchie, Stuart A, John M. C. Connell, Christine F. Kohlhaas, Kenneth Walsh, Ritchie, Stuart A., Connell, John M.C., Connell, John Mc, Salt, Ian P, Alasdair R. Boyd, Yalla, Krishna C.   +19 more
core   +1 more source

Intra-axonal Synthesis of SNAP25 Is Required for the Formation of Presynaptic Terminals

Cell Reports, 2017
Localized protein synthesis is a mechanism for developing axons to react acutely and in a spatially restricted manner to extracellular signals. As such, it is important for many aspects of axonal development, but its role in the formation of presynapses ...
Andreia F.R. Batista, José C. Martínez, Ulrich Hengst   +2 more
doaj   +1 more source

The role of tRNA and ribosome competition in coupling the expression of different mRNAs in Saccharomyces cerevisiae [PDF]

, 2011
Protein synthesis translates information from messenger RNAs into functional proteomes. Because of the finite nature of the resources required by the translational machinery, both the overall protein synthesis activity of a cell and activity on ...
von der Haar, Tobias, David J. Barnes, Barnes, David J., Dominique Chu, Tobias von der Haar, Chu, Dominique   +5 more
core   +1 more source

Local sharing as a predominant determinant of synaptic matrix molecular dynamics. [PDF]

PLoS Biology, 2006
Recent studies suggest that central nervous system synapses can persist for weeks, months, perhaps lifetimes, yet little is known as to how synapses maintain their structural and functional characteristics for so long.
Shlomo Tsuriel, Ran Geva, Pedro Zamorano, Thomas Dresbach, Tobias Boeckers, Eckart D Gundelfinger, Craig C Garner, Noam E Ziv   +7 more
doaj   +1 more source

Local Protein Synthesis in Axonal Growth Cones [PDF]

Cell Adhesion & Migration, 2007
While initially thought to be essentially a developmental characteristic, observed in artificial in vitro models, local protein synthesis in growth cones has been described in the adult, and more interestingly, during nerve regeneration. This emerging field is under intense investigation, revealing new functions of localized protein synthesis that ...
Saulius, Satkauskas, Dominique, Bagnard
openaire   +2 more sources

Synaptopodin Regulates Denervation-Induced Plasticity at Hippocampal Mossy Fiber Synapses

Cells
Neurological diseases can lead to the denervation of brain regions caused by demyelination, traumatic injury or cell death. The molecular and structural mechanisms underlying lesion-induced reorganization of denervated brain regions, however, are a ...
Pia Kruse, Gudrun Brandes, Hanna Hemeling, Zhong Huang, Christoph Wrede, Jan Hegermann, Andreas Vlachos, Maximilian Lenz   +7 more
doaj   +1 more source

Current Advances in Local Protein Synthesis and Synaptic Plasticity [PDF]

The Journal of Neuroscience, 2006
Local or dendritic protein synthesis is required for long-term functional synaptic change, such as long-term potentiation (LTP) and long-term depression (LTD). LTP and LTD both rely on similar signal transduction cascades, which regulate translation initiation.
Brad E, Pfeiffer, Kimberly M, Huber
openaire   +2 more sources