RNA localization mechanisms transcend cell morphology [PDF]
eLife, 2023 RNA molecules are localized to specific subcellular regions through interactions between RNA regulatory elements and RNA binding proteins (RBPs). Generally, our knowledge of the mechanistic details behind the localization of a given RNA is restricted to ...
Raeann Goering +3 more
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Application of RNA subcellular fraction estimation method to explore RNA localization regulation [PDF]
G3: Genes, Genomes, Genetics, 2021 RNA localization is involved in multiple biological processes. Recent advances in subcellular fractionation-based sequencing approaches uncovered localization pattern on a global scale. Most of existing methods adopt relative localization ratios (such as
Xiaomin Dai +8 more
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RNA localization in confined cells depends on cellular mechanical activity and contributes to confined migration [PDF]
iScience, 2022 Summary: Cancer cells experience mechanical confining forces during metastasis and, consequently, can alter their migratory mechanisms. Localization of numerous mRNAs to cell protrusions contributes to cell polarization and migration and is controlled by
Rebecca A. Moriarty +2 more
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Decoding subcellular RNA localization one molecule at a time [PDF]
Genome BiologyEukaryotic cells are highly structured and composed of multiple membrane-bound and membraneless organelles. Subcellular RNA localization is a critical regulator of RNA function, influencing various biological processes.
Josep Biayna, Gabrijela Dumbović
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Analyzing RNA Localization Using the RNA Proximity Labeling Method OINC-seq [PDF]
Bio-ProtocolThousands of RNAs are localized to specific subcellular locations, and these localization patterns are often required for optimal cell function.
Megan Pockalny +3 more
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Inducible control of subcellular RNA localization using a synthetic protein-RNA aptamer interaction. [PDF]
PLoS ONE, 2012 Evidence is accumulating in support of the functional importance of subcellular RNA localization in diverse biological contexts. In different cell types, distinct RNA localization patterns are frequently observed, and the available data indicate that ...
Brian J Belmont, Jacquin C Niles
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Mapping subcellular RNA localization with proximity labeling [PDF]
Acta Biochimica et Biophysica SinicaThe subcellular localization of RNA is critical to a variety of physiological and pathological processes. Dissecting the spatiotemporal regulation of the transcriptome is key to understanding cell function and fate.
Liu Jiapeng +3 more
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Axonal RNA localization is essential for long-term memory [PDF]
Nature CommunicationsLocalization of mRNAs to neuronal terminals, coupled to local translation, has emerged as a prevalent mechanism controlling the synaptic proteome. However, the physiological regulation and function of this process in the context of mature in vivo memory ...
Bruna R. de Queiroz +14 more
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bicoid RNA localization requires the trans-Golgi network [PDF]
Hereditas, 2019 Background The formation of the bicoid (bcd) mRNA gradient is a crucial step for Bcd protein gradient formation in Drosophila. In the past, a microtubule (MT)-based cortical network had been shown to be indispensable for bcd mRNA transport to the ...
Xiaoli Cai +2 more
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FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences [PDF]
eLife, 2020 The sorting of RNA molecules to subcellular locations facilitates the activity of spatially restricted processes. We have analyzed subcellular transcriptomes of FMRP-null mouse neuronal cells to identify transcripts that depend on FMRP for efficient ...
Raeann Goering +7 more
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