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RNA LOCALIZATION IN DEVELOPMENT [PDF]
Annual Review of Biochemistry, 1998 Cytoplasmic RNA localization is an evolutionarily ancient mechanism for producing cellular asymmetries. This review considers RNA localization in the context of animal development. Both mRNAs and non-protein-coding RNAs are localized in Drosophila, Xenopus, ascidian, zebrafish, and echinoderm oocytes and embryos, as well as in a variety of developing ...
Ramona L Cooperstock, Howard D Lipshitz
exaly +4 more sources
Genomic analysis of RNA localization [PDF]
RNA Biology, 2014 The localization of mRNAs to specific subcellular sites is widespread, allowing cells to spatially restrict and regulate protein production, and playing important roles in development and cellular physiology. This process has been studied in mechanistic detail for several RNAs.
J Matthew Taliaferro +2 more
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Protein localization with flexible DNA or RNA. [PDF]
PLoS ONE, 2012 Localization of activity is ubiquitous in life, and also within sub-cellular compartments. Localization provides potential advantages as different proteins involved in the same cellular process may supplement each other on a fast timescale. It might also
Sebastian Bernhardsson +2 more
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RNA N6-Methyladenosine and the Regulation of RNA Localization and Function in the Brain
Trends in Neurosciences, 2020 A major challenge in neurobiology in the 21st century is to understand how the brain adapts with experience. Activity-dependent gene expression is integral to the synaptic plasticity underlying learning and memory; however, this process cannot be explained by a simple linear trajectory of transcription to translation within a specific neuronal ...
Sachithrani U Madugalle +2 more
exaly +7 more sources
Editorial: RNA Localization and Localized Translation in Neurons [PDF]
Frontiers in Integrative Neuroscience, 2022 Published ...
Shannon Farris +4 more
openaire +3 more sources
A review from biological mapping to computation-based subcellular localization
Molecular Therapy: Nucleic Acids, 2023 Subcellular localization is crucial to the study of virus and diseases. Specifically, research on protein subcellular localization can help identify clues between virus and host cells that can aid in the design of targeted drugs.
Jing Li, Quan Zou, Lei Yuan
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Meiotic long non-coding meiRNA accumulates as a dot at its genetic locus facilitated by Mmi1 and plays as a decoy to lure Mmi1 [PDF]
Open Biology, 2014 Long non-coding RNAs (lncRNAs) play key roles in the formation of nuclear bodies. In the fission yeast Schizosaccharomyces pombe, a lncRNA species termed meiRNA forms a nuclear dot structure at its own genetic locus, the sme2 locus, with its protein ...
Yuichi Shichino +2 more
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RNA localization mechanisms transcend cell morphology
eLife, 2023 RNA molecules are localized to specific subcellular regions through interactions between RNA regulatory elements and RNA binding proteins (RBPs). Generally, our knowledge of the mechanistic details behind the localization of a given RNA is restricted to ...
Raeann Goering +3 more
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Inducible control of subcellular RNA localization using a synthetic protein-RNA aptamer interaction. [PDF]
PLoS ONE, 2012 Evidence is accumulating in support of the functional importance of subcellular RNA localization in diverse biological contexts. In different cell types, distinct RNA localization patterns are frequently observed, and the available data indicate that ...
Brian J Belmont, Jacquin C Niles
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Prediction of RNA subcellular localization: Learning from heterogeneous data sources
iScience, 2021 Summary: RNA subcellular localization has recently emerged as a widespread phenomenon, which may apply to the majority of RNAs. The two main sources of data for characterization of RNA localization are sequence features and microscopy images, such as ...
Anca Flavia Savulescu +3 more
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