Results 41 to 50 of about 4,574 (248)

Mechanical Fractionation of Cultured Neuronal Cells into Cell Body and Neurite Fractions

Bio-Protocol, 2021
Many cells contain spatially defined subcellular regions that perform specialized tasks enabled by localized proteins. The subcellular distribution of these localized proteins is often facilitated by the subcellular localization of the RNA molecules that
Ankita Arora, Raeann Goering, Hei-Yong Lo, J. Taliaferro   +3 more
doaj   +1 more source

Gamma-tubulin37C and gamma-tubulin ring complex protein 75 are essential for bicoid RNA localization during drosophila oogenesis

, 2002
bicoid (bcd) RNA localization requires the activity of exuperantia and swallow at sequential steps of oogenesis and is microtubule dependent. In a genetic screen, we identified two novel genes essential for bcd RNA localization.
Schnorrer, F. ; https://orcid.org/, Luschnig, S. ; https://orcid.org/, Koch, I., Nüsslein-Volhard, C. ; https://orcid.org/   +3 more
core   +2 more sources

RNA Locally Optimal Secondary Structures [PDF]

Journal of Computational Biology, 2012
RNA locally optimal secondary structures provide a concise and exhaustive description of all possible secondary structures of a given RNA sequence, and hence a very good representation of the RNA folding space. In this paper, we present an efficient algorithm that computes all locally optimal secondary structures for any folding model that takes into ...
Saffarian, Azadeh, Giraud, Mathieu, de Monte, Antoine, Touzet, Hélène   +3 more
openaire   +4 more sources

High-throughput identification of RNA localization elements in neuronal cells

, 2022
Hundreds of RNAs are enriched in the projections of neuronal cells. For the vast majority of them, though, the sequence elements that regulate their localization are unknown.
Taliaferro, J Matthew, Moffatt, Charlie, Russ, Holger A., Taliaferro, J. Matthew, Russ, Holger A, Moor, Andreas E., Becker, Raquel, Brown, Maya, Arora, Ankita, Eletto, Davide, Castro-Gutierrez, Roberto, Moor, Andreas E   +11 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Assaying RNA Localization in Situ with Spatially Restricted Nucleobase Oxidation

, 2017
© 2017 American Chemical Society. We report herein a novel chemical-genetic method for assaying RNA localization within living cells. RNA localization is critical for normal physiology as well as the onset of cancer and neurodegenerative disorders ...
Ying Li, Mahima B. Aggarwal, Aggarwal, Mahima B., Li, Ying, Nguyen, Kim, Spitale, Robert C., Ke, Ke, Robert C. Spitale, Kim Nguyen, Ke Ke   +9 more
core   +1 more source

Protein interactions in Xenopus germ plasm RNP particles [PDF]

, 2013
Hermes is an RNA-binding protein that we have previously reported to be found in the ribonucleoprotein (RNP) particles of Xenopus germ plasm, where it is associated with various RNAs, including that encoding the germ line determinant Nanos1.
Nijjar, Sarbjit, Woodland, Hugh R., Sarbjit Nijjar, Hugh R. Woodl, Nijjar Sarbjit, Woodland Hugh R., Hugh R Woodland   +6 more
core   +1 more source

Local similarity in RNA secondary structures [PDF]

Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003, 2004
We present a systematic treatment of alignment distance and local similarity algorithms on trees and forests. We build upon the tree alignment algorithm for ordered trees given by Jiang et. al (1995) and extend it to calculate local forest alignments, which is essential for finding local similar regions in RNA secondary structures.
Höchsmann, Matthias, Töller, Thomas, Giegerich, Robert, Kurtz, Stefan   +3 more
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source