Results 11 to 20 of about 4,574 (248)
Decoding subcellular RNA localization one molecule at a time
Genome BiologyEukaryotic cells are highly structured and composed of multiple membrane-bound and membraneless organelles. Subcellular RNA localization is a critical regulator of RNA function, influencing various biological processes.
Josep Biayna, Gabrijela Dumbović
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A computational framework to study sub-cellular RNA localization
Nature Communications, 2018 Automated analysis of RNA localisation in smFISH data has been elusive. Here, the authors simulate and use a large dataset of images to design and validate a framework for highly accurate classification of sub-cellular RNA localisation patterns from ...
Aubin Samacoits +9 more
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Computational and Structural Biotechnology Journal, 2022 Subcellular localization of Ribonucleic Acid (RNA) molecules provide significant insights into the functionality of RNAs and helps to explore their association with various diseases.
Muhammad Nabeel Asim +7 more
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Landscape and functions of RNA localization in the Drosophila follicular epithelium [PDF]
, 2021 The mechanisms and roles underlying the phenomenon of RNA localization in differentiated tissues are poorly characterized. Drosophila follicular epithelium represents a good model to study RNA localization in the context of an adult tissue, for several ...
Cassella, Lucia
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Quantitative analysis of subcellular distributions with an open-source, object-based tool
Biology Open, 2020 The subcellular localization of objects, such as organelles, proteins, or other molecules, instructs cellular form and function. Understanding the underlying spatial relationships between objects through colocalization analysis of microscopy images is a ...
Pearl V. Ryder, Dorothy A. Lerit
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RNA localization in bacteria [PDF]
RNA Biology, 2014 One of the most important discoveries in the field of microbiology in the last two decades is that bacterial cells have intricate subcellular organization. This understanding has emerged mainly from the depiction of spatial and temporal organization of proteins in specific domains within bacterial cells, e.g., midcell, cell poles, membrane and ...
Avi-ad Avraam, Buskila +2 more
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RNA Localization in Bacteria [PDF]
Microbiology Spectrum, 2018 ABSTRACT Diverse mechanisms and functions of posttranscriptional regulation by small regulatory RNAs and RNA-binding proteins have been described in bacteria. In contrast, little is known about the spatial organization of RNAs in bacterial cells.
Jingyi, Fei, Cynthia M, Sharma
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iScience, 2022 Summary: RNA localization and biomolecular condensate formation are key biological strategies for organizing the cytoplasm and generating cellular polarity. In Xenopus oocytes, RNAs required for germ layer patterning localize in biomolecular condensates,
Sarah E. Cabral +2 more
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Application of RNA subcellular fraction estimation method to explore RNA localization regulation
G3: Genes, Genomes, Genetics, 2021 RNA localization is involved in multiple biological processes. Recent advances in subcellular fractionation-based sequencing approaches uncovered localization pattern on a global scale. Most of existing methods adopt relative localization ratios (such as
Xiaomin Dai +8 more
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Localization of RNA and translation in the mammalian oocyte and embryo. [PDF]
PLoS ONE, 2018 The tight correlation between mRNA distribution and subsequent protein localization and function indicate a major role for mRNA localization within the cell.
Denisa Jansova +4 more
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