Results 1 to 10 of about 463,726 (249)
Local Translation in Nervous System Pathologies [PDF]
Frontiers in Integrative Neuroscience, 2021 Dendrites and axons can extend dozens to hundreds of centimeters away from the cell body so that a single neuron can sense and respond to thousands of stimuli.
María Gamarra +9 more
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Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation [PDF]
Cell Reports, 2021 Summary: Synaptic structural plasticity, key to long-term memory storage, requires translation of localized RNAs delivered by long-distance transport from the neuronal cell body. Mechanisms and regulation of this system remain elusive.
Supriya Swarnkar +12 more
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Cell Reports, 2020 Summary: Local translation is a conserved mechanism conferring cells the ability to quickly respond to local stimuli. In the brain, it has been recently reported in astrocytes, whose fine processes contact blood vessels and synapses.
Noémie Mazaré +13 more
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Axonal Transport and Local Translation of mRNA in Neurodegenerative Diseases [PDF]
Frontiers in Molecular Neuroscience, 2021 Since neurons have long neurites including axons, it is crucial for the axons to transport many intracellular substances such as proteins and mitochondria in order to maintain their morphology and function.
Seiichi Nagano +2 more
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The Coordination of Local Translation, Membranous Organelle Trafficking, and Synaptic Plasticity in Neurons [PDF]
Frontiers in Cell and Developmental Biology, 2021 Neurons are highly complex polarized cells, displaying an extraordinary degree of spatial compartmentalization. At presynaptic and postsynaptic sites, far from the cell body, local protein synthesis is utilized to continually modify the synaptic proteome,
Dipen Rajgor +2 more
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Nano-pulling stimulates axon regeneration in dorsal root ganglia by inducing stabilization of axonal microtubules and activation of local translation [PDF]
Frontiers in Molecular NeuroscienceIntroductionAxonal plasticity is strongly related to neuronal development as well as regeneration. It was recently demonstrated that active mechanical tension, intended as an extrinsic factor, is a valid contribution to the modulation of axonal ...
Alessandro Falconieri +3 more
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Local Translation Across Neural Development: A Focus on Radial Glial Cells, Axons, and Synaptogenesis [PDF]
Frontiers in Molecular Neuroscience, 2021 In the past two decades, significant progress has been made in our understanding of mRNA localization and translation at distal sites in axons and dendrites.
Manasi Agrawal, Kristy Welshhans
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Could an Impairment in Local Translation of mRNAs in Glia be Contributing to Pathogenesis in ALS? [PDF]
Frontiers in Molecular Neuroscience, 2019 One of the key pathways implicated in amyotrophic lateral sclerosis (ALS) pathogenesis is abnormal RNA processing. Studies to date have focussed on defects in RNA stability, splicing, and translation, but this review article will focus on the largely ...
Samantha K. Barton +9 more
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Cell Reports, 2017 During brain wiring, cue-induced axon behaviors such as directional steering and branching are aided by localized mRNA translation. Different guidance cues elicit translation of subsets of mRNAs that differentially regulate the cytoskeleton, yet little ...
Anaïs Bellon +14 more
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Biomolecules, 2020 During neural development, growth cones, very motile compartments of tips of axons, lead axonal extension to the correct targets. Subsequently, presynapses, another axonal compartment with vigorous trafficking of synaptic vesicles, emerge to form ...
Yukio Sasaki
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