Results 41 to 50 of about 463,726 (249)

On the Locality of Attention in Direct Speech Translation

Proceedings of the 60th Annual Meeting of the Association for Computational Linguistics: Student Research Workshop, 2022
ACL-SRW 2022.
Alastruey Lasheras, Belén, Ferrando Monsonís, Javier, Gallego Olsina, Gerard Ion, Ruiz Costa-Jussà, Marta   +3 more
openaire   +4 more sources

Astrocyte-secreted factors modulate synaptic protein synthesis as revealed by puromycin labeling of isolated synaptosomes

Frontiers in Molecular Neuroscience
The synaptic proteome can be shaped by proteins transported from the neuronal soma and/or by mRNAs that are delivered to synapses where proteins are locally synthesized. This last mechanism is known as local translation.
Aida de la Cruz-Gambra, Aida de la Cruz-Gambra, Jimena Baleriola, Jimena Baleriola   +3 more
doaj   +1 more source

G Protein-Coupled Receptors As Regulators of Localized Translation: The Forgotten Pathway?

Frontiers in Endocrinology, 2018
G protein-coupled receptors (GPCRs) exert their physiological function by transducing a complex signaling network that coordinates gene expression and dictates the phenotype of highly differentiated cells.
Aurélie Tréfier, Aurélie Tréfier, Aurélie Tréfier, Aurélie Tréfier, Lucie P. Pellissier, Lucie P. Pellissier, Lucie P. Pellissier, Lucie P. Pellissier, Astrid Musnier, Astrid Musnier, Astrid Musnier, Astrid Musnier, Eric Reiter, Eric Reiter, Eric Reiter, Eric Reiter, Florian Guillou, Florian Guillou, Florian Guillou, Florian Guillou, Pascale Crépieux, Pascale Crépieux, Pascale Crépieux, Pascale Crépieux   +23 more
doaj   +1 more source

Healthcare professionals’ perspectives on the barriers and enablers of cancer clinical trial participation among Arabic-speaking cancer patients in Australia: a qualitative study

Trials
Background Culturally and ethnically diverse communities are underrepresented in cancer clinical trials, further contributing to existing health inequities.
Rayan Saleh Moussa, Layla M Edwards, Michael Camit, Christine Jeyachandran, Tim Luckett, Ben Smith, Bernadette Brady, Slavica Kochovska, Charbel Bejjani, Maria Gonzalez, Nadine El-Kabbout, Arwa Abousamra, Amin Gadalla, Iman Zakhary, Azhar Matti, Randa Kattan, Verena Wu, Wei Chua, Karen Wong, Shalini Subramaniam, Gemma McErlean, Balwinder Sidhu, Matthew Jennings, Sandra Avery, Deme Karikios, Frances Boyle, Wafa Trad, Weng Ng, Stephen Della-Fiorentina, Martin Hong, Udit Nindra, Sally Fielding, Meera Agar, Abhijit Pal   +33 more
doaj   +1 more source

Accumulating Evidence for Axonal Translation in Neuronal Homeostasis

Frontiers in Neuroscience, 2017
The specialized structure of the neuron requires that homeostasis is sustained over the meter or more that may separate a cell body from its axonal terminus.
Emily L. Spaulding, Emily L. Spaulding, Robert W. Burgess, Robert W. Burgess   +3 more
doaj   +1 more source

Omics Approach to Axonal Dysfunction of Motor Neurons in Amyotrophic Lateral Sclerosis (ALS)

Frontiers in Neuroscience, 2020
Amyotrophic lateral sclerosis (ALS) is an intractable adult-onset neurodegenerative disease that leads to the loss of upper and lower motor neurons (MNs). The long axons of MNs become damaged during the early stages of ALS.
Naoki Suzuki, Naoki Suzuki, Tetsuya Akiyama, Hitoshi Warita, Masashi Aoki   +4 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Cataloguing and Selection of mRNAs Localized to Dendrites in Neurons and Regulated by RNA-Binding Proteins in RNA Granules

Biomolecules, 2020
Spatiotemporal translational regulation plays a key role in determining cell fate and function. Specifically, in neurons, local translation in dendrites is essential for synaptic plasticity and long-term memory formation.
Rie Ohashi, Nobuyuki Shiina
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The m6A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons

Advanced Science, 2021
Messenger RNA m6A modification is shown to regulate local translation in axons. However, how the m6A codes in axonal mRNAs are read and decoded by the m6A reader proteins is still unknown. Here, it is found that the m6A readers YTHDF1 and YTHDF2 are both
Jun Yu, Yuanchu She, Lixin Yang, Mengru Zhuang, Peng Han, Jianhui Liu, Xiaoyan Lin, Nijia Wang, Mengxian Chen, Chunxuan Jiang, Yujia Zhang, Yujing Yuan, Sheng‐Jian Ji   +12 more
doaj   +1 more source