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Molecular mechanisms of synaptogenesis
Frontiers in Synaptic Neuroscience, 2022 Synapses are the basic units for information processing and storage in the nervous system. It is only when the synaptic connection is established, that it becomes meaningful to discuss the structure and function of a circuit.
Cai Qi +4 more
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Activated Bone Marrow-Derived Macrophages Eradicate Alzheimer's-Related Aβ42 Oligomers and Protect Synapses [PDF]
Frontiers in Immunology, 2020 Impaired synaptic integrity and function due to accumulation of amyloid β-protein (Aβ42) oligomers is thought to be a major contributor to cognitive decline in Alzheimer's disease (AD). However, the exact role of Aβ42 oligomers in synaptotoxicity and the
Songlin Li +18 more
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Astrocytic Factors Controlling Synaptogenesis: A Team Play
Cells, 2020 Astrocytes are essential players in brain circuit development and homeostasis, controlling many aspects of synapse formation, function, plasticity and elimination both during development and adulthood.
Giuliana Fossati +2 more
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Frontiers in Cell and Developmental Biology, 2022 Lynx1 is a glycosylphosphatidylinositol (GPI)-linked protein shown to affect synaptic plasticity through modulation of nicotinic acetylcholine receptor (nAChR) subtypes in the brain.
Sydney V. Doss +11 more
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A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila. [PDF]
PLoS ONE, 2011 Neuromuscular (NM) synaptogenesis is a tightly regulated process. We previously showed that in flies, Drosophila Nedd4 (dNedd4/dNedd4S) is required for proper NM synaptogenesis by promoting endocytosis of commissureless from the muscle surface, a pre ...
Yunan Zhong +5 more
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Cell Reports, 2021 Summary: The mechanisms controlling the post-natal maturation of astrocytes play a crucial role in ensuring correct synaptogenesis. We show that mitochondrial biogenesis in developing astrocytes is necessary for coordinating post-natal astrocyte ...
Tamara Zehnder +8 more
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Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control
Nature Communications, 2023 Synaptogenesis is essential for circuit development; however, it is unknown whether it is critical for the establishment and performance of goal-directed voluntary behaviors.
Francesco Paolo Ulloa Severino +12 more
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Arhgef5 Binds α-Dystrobrevin 1 and Regulates Neuromuscular Junction Integrity
Frontiers in Molecular Neuroscience, 2020 The neuromuscular junctions (NMJs) connect muscle fibers with motor neurons and enable the coordinated contraction of skeletal muscles. The dystrophin-associated glycoprotein complex (DGC) is an essential component of the postsynaptic machinery of the ...
Krzysztof M. Bernadzki +14 more
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Frontiers in Molecular Neuroscience, 2021 Bassoon is a core scaffold protein of the presynaptic active zone. In brain synapses, the C-terminus of Bassoon is oriented toward the plasma membrane and its N-terminus is oriented toward synaptic vesicles.
Tina Ghelani +7 more
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Functional Network Profiles in ARSACS Disclosed by Aptamer-Based Proteomic Technology
Frontiers in Neurology, 2021 Although the genetic basis of autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) has been uncovered, our poor understanding of disease mechanisms requires new light on functional pathways and modifying factors to improve early diagnostic ...
Federica Morani +10 more
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