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Synaptogenesis [PDF]

open access: yesCurrent Biology, 2014
SummarySynapses are specialized asymmetric cell–cell connections permitting the controlled transfer of an electrical or chemical signal between a presynaptic neuronal cell and a postsynaptic target cell (e.g. neuron or muscle).
Sigrist, Stephan J.   +3 more
core   +4 more sources

Nerve, Muscle, and Synaptogenesis [PDF]

open access: yesCells, 2019
The vertebrate skeletal neuromuscular junction (NMJ) has long served as a model system for studying synapse structure, function, and development. Over the last several decades, a neuron-specific isoform of agrin, a heparan sulfate proteoglycan, has been ...
Swenarchuk, Lauren Eric   +1 more
core   +7 more sources

Synaptogenesis in hippocampal cultures

open access: yesCellular and Molecular Life Sciences CMLS, 1999
Hippocampal cultures offer unique advantages for the study of neuronal development and synaptogenesis. Studies performed on this model enabled dissection of the temporal sequence of events which lead to the differentiation of pre- and postsynaptic ...
E. Pravettoni   +4 more
core   +3 more sources

Astrocyte-Neuron Signaling in Synaptogenesis [PDF]

open access: yesFrontiers in Cell and Developmental Biology, 2021
Astrocytes are the key component of the central nervous system (CNS), serving as pivotal regulators of neuronal synapse formation and maturation through their ability to dynamically and bidirectionally communicate with synapses throughout life.
Lili Shan   +9 more
doaj   +3 more sources

NEUROTROPHIC ACTIONS OF LEPTIN IN HIPPOCAMPAL SYNAPTOGENESIS DURING DEVELOPMENT [PDF]

open access: yes, 2020
Leptin is a crucial neurotrophic factor during the development of the hippocampus. Mouse models that are deficient in leptin synthesis or functional leptin receptors exhibit depression, anxiety, and cognitive deficits, the disorders partly associated ...
Sahin, Gulcan
core   +4 more sources

Commissureless endocytosis is correlated with initiation of neuromuscular synaptogenesis

open access: yes, 1998
We show that the Commissureless (COMM) transmembrane protein is required at neuromuscular synaptogenesis. All muscles in the Drosophila embryo express COMM during the period of motoneuron-muscle interaction.
Wolf, B, Seeger, M A, Chiba, A
core   +4 more sources

Synaptogenesis [PDF]

open access: yesWormBook, 2005
Synaptogenesis is a process involving the formation of a neurotransmitter release site in the presynaptic neuron and a receptive field at the postsynaptic partners, and the precise alignment of pre- and post-synaptic specializations. In C. elegans synapses are found as en passant axonal swellings along the nerve processes.
openaire   +2 more sources

Deletion of LRP1 From Astrocytes Modifies Neuronal Network Activity in an in vitro Model of the Tripartite Synapse

open access: yesFrontiers in Cellular Neuroscience, 2021
The low-density lipoprotein receptor-related protein 1 (LRP1) is a transmembrane receptor that binds over 40 potential ligands and is involved in processes such as cell differentiation, proliferation, and survival.
Ramona Romeo   +3 more
doaj   +1 more source

Liprin-α-1 is a novel component of the murine neuromuscular junction and is involved in the organization of the postsynaptic machinery

open access: yesScientific Reports, 2017
Neuromuscular junctions (NMJs) are specialized synapses that connect motor neurons to skeletal muscle fibers and orchestrate proper signal transmission from the nervous system to muscles.
Krzysztof M. Bernadzki   +6 more
doaj   +1 more source

The equilibrium between antagonistic signaling pathways determines the number of synapses in Drosophila.

open access: yesPLoS ONE, 2017
The number of synapses is a major determinant of behavior and many neural diseases exhibit deviations in that number. However, how signaling pathways control this number is still poorly understood.
Sheila Jordán-Álvarez   +4 more
doaj   +1 more source

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