Results 21 to 30 of about 44,470 (243)
Chemogenetic manipulation of astrocyte activity at the synapse— a gateway to manage brain disease
Frontiers in Cell and Developmental Biology, 2023 Astrocytes are the major glial cell type in the central nervous system (CNS). Initially regarded as supportive cells, it is now recognized that this highly heterogeneous cell population is an indispensable modulator of brain development and function ...
Maria João Pereira +6 more
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Transcriptional Coordination of Synaptogenesis and Neurotransmitter Signaling [PDF]
, 2015 SummaryDuring nervous system development, postmitotic neurons face the challenge of generating and structurally organizing specific synapses with appropriate synaptic partners.
Kerk, Sze Yen +5 more
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Response of Astrocyte Subpopulations Following Spinal Cord Injury
Cells, 2022 There is growing appreciation for astrocyte heterogeneity both across and within central nervous system (CNS) regions, as well as between intact and diseased states. Recent work identified multiple astrocyte subpopulations in mature brain. Interestingly,
R. Vivian Allahyari +9 more
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Involvement of JNK1 in Neuronal Polarization During Brain Development
Cells, 2020 The c-Jun N-terminal Kinases (JNKs) are a group of regulatory elements responsible for the control of a wide array of functions within the cell. In the central nervous system (CNS), JNKs are involved in neuronal polarization, starting from the cell ...
Rubén Darío Castro-Torres +9 more
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Episodic memory: neurological and neuromediator mechanisms
Анналы клинической и экспериментальной неврологии, 2017 Significant advances in understanding of neurological and neuromediatormechanisms of memory along with the causes ofmemory decline in aging were achieved recently.
A. G. Polunina, E. A. Bryun
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Cell Reports, 2021 Summary: Neuronal synapse formation is critical for brain development and depends on secreted factors from astrocytes. Here, we report that small extracellular vesicles (EVs) secreted from primary astrocytes, but not from neurons or C6 glioma cells ...
Mikin R. Patel, Alissa M. Weaver
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IL-6 boosts synaptogenesis STAT!
, 2021 Maternal infection during pregnancy increases the offspring's risk of developing neurodevelopmental disorders. While IL-6 is involved, the mechanism by which IL-6 and other cytokines affect developing neural circuits is unknown. In this issue of Immunity,
Schafer, Dorothy P, Faust, Travis E
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Frontiers in Pharmacology, 2017 Depression is a devastating mental disorder that affects 20% of the population worldwide. Despite their proven efficacy, antidepressants present a delayed onset of action and serious adverse effects.
Alaeddine Djillani +5 more
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Frontiers in Immunology, 2020 Impaired synaptic integrity and function due to accumulation of amyloid β-protein (Aβ42) oligomers is thought to be a major contributor to cognitive decline in Alzheimer's disease (AD). However, the exact role of Aβ42 oligomers in synaptotoxicity and the
Songlin Li +18 more
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Cell Reports, 2016 Hyperfunction of the mTORC1 pathway has been associated with idiopathic and syndromic forms of autism spectrum disorder (ASD), including tuberous sclerosis, caused by loss of either TSC1 or TSC2. It remains largely unknown how developmental processes and
Veronica Costa +22 more
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