Results 21 to 30 of about 63,572 (265)

Chemogenetic manipulation of astrocyte activity at the synapse— a gateway to manage brain disease

open access: yesFrontiers in Cell and Developmental Biology, 2023
Astrocytes are the major glial cell type in the central nervous system (CNS). Initially regarded as supportive cells, it is now recognized that this highly heterogeneous cell population is an indispensable modulator of brain development and function ...
Maria João Pereira   +6 more
doaj   +1 more source

Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo [PDF]

open access: yes, 2016
Whether neurons can restore their original connectivity patterns during circuit repair is unclear. Taking advantage of the regenerative capacity of zebrafish retina, we show here the remarkable specificity by which surviving neurons reassemble their ...
A Carleton   +49 more
core   +1 more source

Correlation with basic differentiation processes of neurons [PDF]

open access: yes, 1991
The development of the spinal cord involves the proliferation of neurons, their migration to well-defined areas, fiber outgrowth and synapse formation. The present study was designed to correlate the spatiotemporal pattern of expression of synaptophysin,
Altman   +37 more
core   +2 more sources

Response of Astrocyte Subpopulations Following Spinal Cord Injury

open access: yesCells, 2022
There is growing appreciation for astrocyte heterogeneity both across and within central nervous system (CNS) regions, as well as between intact and diseased states. Recent work identified multiple astrocyte subpopulations in mature brain. Interestingly,
R. Vivian Allahyari   +9 more
doaj   +1 more source

Putative cell adhesion membrane protein Vstm5 regulates neuronal morphology and migration in the central nervous system [PDF]

open access: yes, 2016
During brain development, dynamic changes in neuronal membranes perform critical roles in neuronal morphogenesis and migration to create functional neural circuits.
Ko, Kwang Woo   +5 more
core   +2 more sources

Involvement of JNK1 in Neuronal Polarization During Brain Development

open access: yesCells, 2020
The c-Jun N-terminal Kinases (JNKs) are a group of regulatory elements responsible for the control of a wide array of functions within the cell. In the central nervous system (CNS), JNKs are involved in neuronal polarization, starting from the cell ...
Rubén Darío Castro-Torres   +9 more
doaj   +1 more source

Morphological plasticity of astroglia: Understanding synaptic microenvironment [PDF]

open access: yes, 2015
Memory formation in the brain is thought to rely on the remodeling of synaptic connections which eventually results in neural network rewiring. This remodeling is likely to involve ultrathin astroglial protrusions which often occur in the immediate ...
Heller, JP, Rusakov, DA
core   +1 more source

Nerve, Muscle, and Synaptogenesis [PDF]

open access: yesCells, 2019
The vertebrate skeletal neuromuscular junction (NMJ) has long served as a model system for studying synapse structure, function, and development. Over the last several decades, a neuron-specific isoform of agrin, a heparan sulfate proteoglycan, has been identified as playing a central role in synapse formation at all vertebrate skeletal neuromuscular ...
openaire   +5 more sources

Episodic memory: neurological and neuromediator mechanisms

open access: yesАнналы клинической и экспериментальной неврологии, 2017
Significant advances in understanding of neurological and neuromediatormechanisms of memory along with the causes ofmemory decline in aging were achieved recently.
A. G. Polunina, E. A. Bryun
doaj   +1 more source

Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-β signaling

open access: yesCell Reports, 2021
Summary: Neuronal synapse formation is critical for brain development and depends on secreted factors from astrocytes. Here, we report that small extracellular vesicles (EVs) secreted from primary astrocytes, but not from neurons or C6 glioma cells ...
Mikin R. Patel, Alissa M. Weaver
doaj   +1 more source

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