Results 31 to 40 of about 44,470 (243)
Perils of paediatric anaesthesia and novel molecular approaches: An evidence-based review
Indian Journal of Anaesthesia, 2015 Evolution of anaesthesia has been largely helped by progress of evidence-based medicine. In spite of many advancements in anaesthesia techniques and availability of newer and safer drugs, much more needs to be explored scientifically for the development ...
Sukhminder Jit Singh Bajwa +2 more
doaj +1 more source
Conservation and Innovation: Versatile Roles for LRP4 in Nervous System Development
Journal of Developmental Biology, 2021 As the nervous system develops, connections between neurons must form to enable efficient communication. This complex process of synaptic development requires the coordination of a series of intricate mechanisms between partner neurons to ensure pre- and
Alison T. DePew, Timothy J. Mosca
doaj +1 more source
Thrombospondins and synaptogenesis.
Neural regeneration research, 2012 Here, we review research on the mechanisms underlying the ability of thrombospondin to promote synaptogenesis and examine its role in central nervous system diseases and drug actions. Thrombospondin secreted by glial cells plays a critical role in synaptogenesis and maintains synapse stability.
Wang, Bin, Guo, Weitao, Huang, Yun
openaire +2 more sources
The role of collybistin in gephyrin clustering at inhibitory synapses:facts and open questions
Frontiers in Cellular Neuroscience, 2011 Collybistin (Cb) is a brain-specific GDP/GTP-exchange factor, which interacts with the inhibitory receptor anchoring protein gephyrin. Data from mice carrying an inactivated Cb gene indicate that Cb is required for the formation and maintenance of ...
Theofilos ePapadopoulos +2 more
doaj +1 more source
Cells, 2021 The perturbation of nicotinic cholinergic receptors is thought to underlie many neurodegenerative and neuropsychiatric disorders, such as Alzheimer’s and schizophrenia.
Shadab Batool +6 more
doaj +1 more source
Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair
Advanced Science, EarlyView.We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing +10 more
wiley +1 more source
Population Dynamics and Long-Term Trajectory of Dendritic Spines
Frontiers in Synaptic Neuroscience, 2018 Structural plasticity, characterized by the formation and elimination of synapses, plays a big role in learning and long-term memory formation in the brain.
Ahmet S. Ozcan, Mehmet S. Ozcan
doaj +1 more source
Advanced Science, EarlyView.Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi +9 more
wiley +1 more source
Thrombospondins Are Astrocyte-Secreted Proteins that Promote CNS Synaptogenesis [PDF]
, 2005 SummaryThe establishment of neural circuitry requires vast numbers of synapses to be generated during a specific window of brain development, but it is not known why the developing mammalian brain has a much greater capacity to generate new synapses than
Ullian, Erik M. +9 more
core +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source