Results 41 to 50 of about 44,470 (243)

Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia‐Sensing Logic for Ecological Adaptation in Bactrocera dorsalis

Advanced Science, EarlyView.
Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu, Shuai Zhang, Jie Zhang, Zhen Tian, Yuanbo Xue, Ling Yang, Jun Xu, Guirong Wang   +7 more
wiley   +1 more source

Insight into the Association between Slitrk Protein and Neurodevelopmental and Neuropsychiatric Conditions

Biomolecules
Slitrk proteins belong the leucine-rich repeat transmembrane family and share structural similarities with the Slits and tropomyosin receptor kinase families, which regulate the development of the nervous system.
Nidhi Puranik, Minseok Song
doaj   +1 more source

The Golgi apparatus in neurorestoration

Journal of Neurorestoratology, 2019
The central role of the Golgi apparatus in critical cellular processes such as the transport, processing, and sorting of proteins and lipids has placed it at the forefront of cell science.
Jianyang Liu, Jialin He, Yan Huang, Han Xiao, Zheng Jiang, Zhiping Hu   +5 more
doaj   +1 more source

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

Adaptive Network Stabilization Despite Profound Structural Reorganization in Human Organotypic Cultures

Advanced Science, EarlyView.
Adult human organotypic cortical slices undergo marked neuronal loss, laminar disruption, and glial activation, yet their network activity progressively stabilizes after a variable period. Electrophysiology, longitudinal calcium imaging, and quantitative histology show that structurally remodeled human circuits show adaptive capacity resulting in ...
Estilla Zsófia Tóth, Rebeka Stelcz, Réka Bod, Ábel Petik, Eszter Juhász, Kinga Tóth, Liza Szalai, Nour Essam, Fanni Somogyi, Beatrix Kovács, Amirmahdi Mojtahedzadeh, Attila György Bagó, Loránd Erőss, Péter Orbay, Johanna Petra Szabó, Dániel Fabó, Boglárka Hajnal, Bence Rácz, Daniel Hillier, István Ulbert, Lucia Wittner   +20 more
wiley   +1 more source

Glial Control of Synaptogenesis [PDF]

Cell, 2005
Though all communication between neurons occurs through synapses, we know surprisingly little about the mechanisms inducing their formation. In this issue of Cell, Barres and colleagues (Christopherson et al., 2005) demonstrate that glial-derived thrombospondins and additional soluble glial-secreted factors regulate synapse assembly and functional ...
openaire   +3 more sources

CNS synaptogenesis promoted by glia-derived cholesterol

, 2001
The molecular mechanisms controlling synaptogenesis in the central nervous system (CNS) are poorly understood. Previous reports showed that a glia-derived factor strongly promotes synapse development in cultures of purified CNS neurons. Here, we identify
Mauch, D. (D H), Göritz, C. (C), Karl Nägler, Eva-Christina Müller, Naegler, K., Pfrieger, Frank, Schumacher, S. (S), Müller, E. (E C), Mueller, E.C., Mauch, D.H., Daniela H. Mauch, Albrecht Otto, Frank W. Pfrieger, Otto, A, Schumacher, S., Nägler, K. (K), Christian Göritz, Göritz, C, Pfrieger, F.W., Goeritz, C., Otto, A. (A), Otto, A., Müller, E C, Mauch, D H, Nägler, K, Pfrieger, F. (Frank), Schumacher, S, Stefan Schumacher   +27 more
core   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

MiR-92 Controls Synaptic Development Through Glial Vha55 Regulation

Biomolecules
MicroRNAs (miRNAs) have emerged as important biomarkers for complex neurological conditions. Modifications in synaptic morphology characterize several of these disease states, indicating a possible role of miRNA in modulating synaptic formation and ...
Simon M. Moe, Alicia Taylor, Alan P. Robertson, David Van Vactor, Elizabeth M. McNeill   +4 more
doaj   +1 more source

Synaptic signaling and aberrant RNA splicing in autism spectrum disorders

Frontiers in Synaptic Neuroscience, 2011
Interactions between presynaptic and postsynaptic cellular adhesion molecules drive synapse maturation during development. These trans-synaptic interactions are regulated by alternative splicing of cellular adhesion molecule RNAs, which ultimately ...
Ryan M Smith, Wolfgang eSadee
doaj   +1 more source