Molecular mechanisms behind mRNA localization in axons [PDF]
Open Biology, 2020 Messenger RNA (mRNA) localization allows spatiotemporal regulation of the proteome at the subcellular level. This is observed in the axons of neurons, where mRNA localization is involved in regulating neuronal development and function by orchestrating ...
Benita Turner-Bridger +2 more
doaj +5 more sources
Mitochondrial mRNA localization is governed by translation kinetics and spatial transport. [PDF]
PLoS Computational Biology, 2022 For many nuclear-encoded mitochondrial genes, mRNA localizes to the mitochondrial surface co-translationally, aided by the association of a mitochondrial targeting sequence (MTS) on the nascent peptide with the mitochondrial import complex.
Ximena G Arceo +3 more
doaj +2 more sources
Subcellular mRNA localization patterns across tissues resolved with spatial transcriptomics [PDF]
Nature CommunicationsSubcellular RNA localization, including nuclear retention and apical-basal compartmentalization in polarized epithelia plays a central role in post-transcriptional regulation.
Roy Novoselsky +8 more
doaj +3 more sources
Control of epithelial tissue organization by mRNA localization [PDF]
Nature CommunicationsmRNA localization to specific subcellular regions is common in mammalian cells but poorly understood in terms of its physiological roles. This study demonstrates the functional importance of Net1 mRNA, which we find prominently localized at the dermal ...
Devon E. Mason +9 more
doaj +2 more sources
Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis [PDF]
Nature Communications, 2021 Exon junction complexes (EJCs) that mark untranslated mRNA are involved in transport, translation and nonsense-mediated mRNA decay. Here the authors show centrosomal localization of EJCs which appears to be required for both the localization of NIN mRNA ...
Oh Sung Kwon +9 more
doaj +2 more sources
Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth [PDF]
Nature CommunicationsClb2 is a conserved B-type cyclin essential for mitotic progression in Saccharomyces cerevisiae, with expression tightly regulated at transcriptional and proteolytic levels.
Anna Maekiniemi +8 more
doaj +2 more sources
N4-acetylcytidine (ac4C) promotes mRNA localization to stress granules [PDF]
EMBO ReportsStress granules are an integral part of the stress response that are formed from non-translating mRNAs aggregated with proteins. While much is known about stress granules, the factors that drive their mRNA localization are incompletely described ...
Pavel Kudrin +4 more
doaj +2 more sources
TDP-43 in neurodegeneration and cancer: Decoding the mechanism of mRNA localization and translation [PDF]
Biochemistry and Biophysics ReportsThe localization and translation of mRNAs play crucial roles in maintaining cellular phenotype and function, with RNA-binding protein (RBP) contributing significantly to these processes.
Panjiao Pang +6 more
doaj +2 more sources
Mitochondrial volume fraction and translation duration impact mitochondrial mRNA localization and protein synthesis [PDF]
eLife, 2020 Mitochondria are dynamic organelles that must precisely control their protein composition according to cellular energy demand. Although nuclear-encoded mRNAs can be localized to the mitochondrial surface, the importance of this localization is unclear ...
Tatsuhisa Tsuboi +11 more
doaj +2 more sources
LGLoc as a new language model-driven graph neural network for mRNA localization [PDF]
Scientific ReportsThe localization of mRNA is crucial for the synthesis of functional proteins and plays a significant role in cellular processes. Understanding mRNA localization can enhance applications in disease diagnosis (e.g., cancer, Alzheimer’s) and drug ...
Saeedeh Akbari Rokn Abadi +2 more
doaj +2 more sources