mRNA localization mechanisms in Trypanosoma cruzi.
PLoS ONE, 2013 Asymmetric mRNA localization is a sophisticated tool for regulating and optimizing protein synthesis and maintaining cell polarity. Molecular mechanisms involved in the regulated localization of transcripts are widespread in higher eukaryotes and fungi ...
Lysangela R Alves +5 more
doaj +5 more sources
mRNA localization in metazoans: A structural perspective [PDF]
RNA Biology, 2017 Asymmetric localization of mRNAs is a widespread gene regulatory mechanism that is crucial for many cellular processes. The localization of a transcript involves multiple steps and requires several protein factors to mediate transport, anchoring and ...
D Lazzaretti (21888767) +1 more
core +14 more sources
mRNA Localization in Plant Cells [PDF]
Plant Physiology, 2020 Localization of mRNAs at the subcellular level is an essential mechanism for specific protein targeting and local control of protein synthesis in both eukaryotes and bacteria.
Fukuda, Masako +4 more
core +4 more sources
mRNA localization in the Drosophila germline. [PDF]
RNA Biology, 2016 Localization and the associated translational control of mRNA is a well established mechanism for segregating cellular protein expression. Drosophila has been instrumental in deciphering the prevailing mechanisms of mRNA localization and regulation. This
core +6 more sources
DeepmRNALoc: A Novel Predictor of Eukaryotic mRNA Subcellular Localization Based on Deep Learning
Molecules, 2023 The subcellular localization of messenger RNA (mRNA) precisely controls where protein products are synthesized and where they function. However, obtaining an mRNA’s subcellular localization through wet-lab experiments is time-consuming and expensive, and
Shihang Wang +5 more
doaj +3 more sources
mRNA localization and local translation in neurons. [PDF]
AIMS Neurosci, 2020 The spatial and temporal regulation of gene expression in neurons is an important step in creating functional and structural neuronal networks. The complexity of neurons require differential expression of various proteins in different compartments. Highly polarised cells, such as neurons, respond rapidly to different external stimuli by changing their ...
Mofatteh M.
europepmc +4 more sources
Axonal mRNA localization and local translation in neurodegenerative disease. [PDF]
Neural Regen Res, 2021 The regulation of mRNA localization and local translation play vital roles in the maintenance of cellular structure and function. Many human neurodegenerative diseases, such as fragile X syndrome, amyotrophic lateral sclerosis, Alzheimer’s disease, and spinal muscular atrophy, have been characterized by pathological changes in neuronal axons, including
Lu JX +6 more
europepmc +4 more sources
Alternative mRNA splicing from the glial fibrillary acidic protein (GFAP) gene generates isoforms with distinct subcellular mRNA localization patterns in astrocytes. [PDF]
PLoS ONE, 2013 The intermediate filament network of astrocytes includes Glial fibrillary acidic protein (Gfap) as a major component. Gfap mRNA is alternatively spliced resulting in generation of different protein isoforms where Gfapα is the most predominant isoform ...
Rune Thomsen +3 more
doaj +1 more source
Drosophila Ge-1 promotes P body formation and oskar mRNA localization. [PDF]
PLoS ONE, 2011 mRNA localization coupled with translational control is a widespread and conserved strategy that allows the localized production of proteins within eukaryotic cells.
Shih-Jung Fan +2 more
doaj +1 more source
mRNA stability and m6A are major determinants of subcellular mRNA localization in neurons. [PDF]
Mol Cell, 2023 For cells to perform their biological functions, they need to adopt specific shapes and form functionally distinct subcellular compartments. This is achieved in part via an asymmetric distribution of mRNAs within cells.
Loedige I +10 more
europepmc +2 more sources