Actin and myosin-dependent localization of mRNA to dendrites. [PDF]
PLoS ONE, 2014 The localization of mRNAs within axons and dendrites allows neurons to manipulate protein levels in a time and location dependent manner and is essential for processes such as synaptic plasticity and axon guidance.
Varuzhan Balasanyan, Don B Arnold
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Regulation of processing body formation in the budding yeast "Saccharomyces cerevisiae" [PDF]
, 2014 The life cycle of mRNA, from transcription to decay, is a tightly regulated biological process. mRNA is an essential molecule that the cell utilizes to alter gene expression. Degradation is one process through which the cell can regulate mRNA levels.
Weidner, Julie
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mRNA trafficking and local translation: the Yin and Yang of regulating mRNA localization in neurons [PDF]
Acta Biochimica et Biophysica Sinica, 2011 Localized translation and the requisite trafficking of the mRNA template play significant roles in the nervous system including the establishment of dendrites and axons, axon path-finding, and synaptic plasticity. We provide a brief review on the regulation of localizing mRNA in mammalian neurons through critical post-translational modifications of the
John R, Sinnamon, Kevin, Czaplinski
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Drosophila mRNA Localization During Later Development: Past, Present, and Future
Frontiers in Genetics, 2019 Multiple mechanisms tightly regulate mRNAs during their transcription, translation, and degradation. Of these, the physical localization of mRNAs to specific cytoplasmic regions is relatively easy to detect; however, linking localization to functional ...
Sarah C. Hughes +2 more
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PLoS Biology, 2021 The Drosophila germ plasm is responsible for germ cell formation. Its assembly begins with localization of oskar mRNA to the posterior pole of the oocyte.
Tsubasa Tanaka +2 more
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Systemic movement of FT mRNA and a possible role in floral induction [PDF]
, 2012 FLOWERING LOCUS T (FT) protein is known to be part of the mobile flowering inducing “florigen” signal in plants, but it may not be acting alone. This article reviews the data that FT mRNA can also move systemically throughout the plant and into the shoot
Hong, Yiguo +5 more
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Perturbation of chromatin structure globally affects localization and recruitment of splicing factors [PDF]
, 2012 Chromatin structure is an important factor in the functional coupling between transcription and mRNA processing, not only by regulating alternative splicing events, but also by contributing to exon recognition during constitutive splicing.
Risso, Guillermo, J +47 more
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Immediate translation of Formin DIAPH1 mRNA after its exiting the nucleus is required for its perinuclear localization in fibroblasts. [PDF]
PLoS ONE, 2013 DIAPH1 is a formin protein which promotes actin polymerization, stabilizes microtubules and consequently is involved in cytoskeleton dynamics, cell migration and differentiation.
Guoning Liao, Gang Liu
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An Unbiased Analysis Method to Quantify mRNA Localization Reveals Its Correlation with Cell Motility
Cell Reports, 2012 Localization of mRNA is a critical mechanism used by a large fraction of transcripts to restrict its translation to specific cellular regions. Although current high-resolution imaging techniques provide ample information, the analysis methods for ...
Hye Yoon Park +4 more
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PLoS ONE, 2013 In order for eukaryotic cells to function properly, they must establish polarity. The Drosophila oocyte uses mRNA localization to establish polarity and hence provides a genetically tractable model in which to study this process.
Paulomi Sanghavi +4 more
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