Results 41 to 50 of about 1,406,247 (286)
Localization of RNA and translation in the mammalian oocyte and embryo. [PDF]
PLoS ONE, 2018 The tight correlation between mRNA distribution and subsequent protein localization and function indicate a major role for mRNA localization within the cell.
Denisa Jansova +4 more
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The Role of Alternative Polyadenylation in the Regulation of Subcellular RNA Localization
Frontiers in Genetics, 2022 Alternative polyadenylation (APA) is a widespread and conserved regulatory mechanism that generates diverse 3′ ends on mRNA. APA patterns are often tissue specific and play an important role in cellular processes such as cell proliferation ...
Ankita Arora +8 more
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Intracellular mRNA transport and localized translation
Nature Reviews Molecular Cell Biology, 2021 Fine-tuning cellular physiology in response to intracellular and environmental cues requires precise temporal and spatial control of gene expression. High-resolution imaging technologies to detect mRNAs and their translation state have revealed that all living organisms localize mRNAs in subcellular compartments and create translation hotspots ...
Sulagna Das +4 more
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Systematic imaging reveals features and changing localization of mRNAs in Drosophila development
eLife, 2015 mRNA localization is critical for eukaryotic cells and affects numerous transcripts, yet how cells regulate distribution of many mRNAs to their subcellular destinations is still unknown. We combined transcriptomics and systematic imaging to determine the
Helena Jambor +5 more
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Regulation of mRNA stability via BRF1 and other AU-binding proteins [PDF]
, 2005 Steady state levels of mRNAs are determined by the rate of synthesis and degradation. A well-known cis-element conferring instability to mRNA is the so-called AU-rich element (ARE), which is present in the 3’ untranslated region (3’UTR) of many cytokines,
Schmidlin-Stalder, Martin
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Optimization of Existing RNA Visualization Methods Reveals Novel Dendritic mRNA Dynamics
Frontiers in Bioscience-LandmarkBackground: Spatial-temporal control of mRNA translation in dendrites is important for synaptic plasticity. In response to pre-synaptic stimuli, local mRNA translation can be rapidly triggered near stimulated synapses to supply the ...
Ivan J. Cohen +4 more
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Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference
Molecular Therapy: Nucleic Acids, 2020 RNA interference (RNAi) is a potent mechanism that silences mRNA and protein expression in all cells and tissue types. RNAi is known to exert many of its functional effects in the cytoplasm, and thus, the cellular localization of target mRNA may impact ...
Chantal M. Ferguson +4 more
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Dynein regulates epithelial polarity and the apical localization of stardust A mRNA. [PDF]
PLoS Genetics, 2008 Intense investigation has identified an elaborate protein network controlling epithelial polarity. Although precise subcellular targeting of apical and basolateral determinants is required for epithelial architecture, little is known about how the ...
Sally Horne-Badovinac, David Bilder
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Cell Reports, 2021 Summary: Visualizing mRNA in real time in vivo at high resolution is critical for a full understanding of the spatiotemporal dynamics of gene regulation and function.
Zhimin Li +5 more
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ASH1 mRNA Localization in Three Acts□V [PDF]
, 2001 Novel green fluorescent protein (GFP) labeling techniques targeting specific mRNA transcripts reveal discrete phases of mRNA localization in yeast: packaging, transport, and docking. In budding yeast, ASH1 mRNA is translocated via actin and myosin to the
Kerry Bloom +3 more
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