Results 51 to 60 of about 1,406,247 (286)
Frontiers in Fungal Biology, 2021 Although subcellular localization analysis of proteins fused with enhanced green fluorescence protein (EGFP) has been widely conducted in filamentous fungi, little is known about the localization of messenger RNAs (mRNAs) encoding the EGFP-fused proteins.
Yuki Morita +3 more
doaj +1 more source
Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system [PDF]
, 2015 This work was supported by Medical Research Scotland (FRG353 to VAS), the FP7- Directorate-General for Research and Innovation of the European Commission (EU HEALTHF4-2012-305033 to Coordinating Action Systems Medicine to DJH); the Chief Scientist Office
Smith, V. Anne +7 more
core +1 more source
SnapShot: Subcellular mRNA Localization
Cell, 2017 Many cells localize mRNAs to discrete locations in the cytoplasm. Coupled to local translation, this process affords precise spatial and temporal control of protein function. This SnapShot provides an overview of the key events in subcellular mRNA localization and highlights recent progress in understanding how cytoskeletal motors orchestrate mRNA ...
Mohammad, Mofatteh, Simon L, Bullock
openaire +2 more sources
Local translation of mRNAs in neural development [PDF]
WIREs RNA, 2010 AbstractGrowing axons encounter numerous developmental signals to which they must promptly respond in order to properly form complex neural circuitry. In the axons, these signals are often transduced into a local increase or decrease in protein levels. Contrary to the traditional view that the cell bodies are the exclusive source of axonal proteins, it
Hosung, Jung, Christine E, Holt
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mRNA Transport and Local Translation in Glia
Trends in Cell Biology, 2021 Though mRNA transport and local translation are extensively studied in neurons, emerging evidence supports that these cellular processes are also abundant in non-neuronal glial cells. Here, we explore mechanisms of mRNA transport and local translation in oligodendrocytes, astrocytes, microglia, radial glia, and their functions in development, structure,
Meservey, Lindsey Madsen +2 more
openaire +4 more sources
Recruitment of Staufen2 Enhances Dendritic Localization of an Intron-Containing CaMKIIα mRNA
Cell Reports, 2017 Regulation of mRNA localization is a conserved cellular process observed in many types of cells and organisms. Asymmetrical mRNA distribution plays a particularly important role in the nervous system, where local translation of localized mRNA represents ...
Raúl Ortiz +5 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
PLoS ONE, 2013 In the Drosophila oocyte, gurken (grk) mRNA encodes a secreted TGF-α signal that specifies the future embryonic dorso-ventral axes by altering the fate of the surrounding epithelial follicle cells.
Suzanne M McDermott, Ilan Davis
doaj +1 more source
, 2021 Skeletal muscle is formed by the largest cells in the human body. Muscle cells or myofibers are elongated cells with multiple nuclei evenly distributed in a manner that maximizes the distance between nuclei (Bruusgaard et al., 2003).
Pinheiro, Helena Alexandra Ribeiro de Carvalho
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