Results 71 to 80 of about 1,406,247 (286)
Localized mRNA is the norm [PDF]
The Journal of Cell Biology, 2007 ![Graphic][1] Many different mRNAs (green) stake out specific locations in fly embryo cells. KRAUSE/ELSEVIER Location, location, location. It's critical for real estate, proteins, and—according to work by Eric Lecuyer, Henry Krause, and colleagues (University of Toronto ...
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Characterizing functional domains of the RNA helicase RHAU involved in subcellular localization and RNA interaction [PDF]
, 2008 Posttranscriptional regulation of gene expression is an important and highly regulated process in response to developmental, environmental and metabolic signals.
Chalupníková, Katerina
core +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Localization and anchoring of mRNA in budding yeast [PDF]
Current Biology, 1999 Eukaryotic cells localize selected mRNAs to a region of the cell as a means to sequester proteins. Signals within the 3' untranslated region (3' UTR) facilitate mRNA localization by both actin and microtubule cytoskeletal systems. Recently, an mRNA in the yeast Saccharomyces cerevisiae, ASH1, was shown to coalesce into a discrete particle that is ...
Beach, Dale L. +2 more
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Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
BiomoleculesThe subcellular localization of messenger RNA (mRNA) not only helps us to understand the localization regulation of gene expression but also helps to understand the relationship between RNA localization pattern and human disease mechanism, which has ...
Xiao Wang, Lixiang Yang, Rong Wang
doaj +1 more source
Mammalian Neuronal mRNA Transport Complexes: The Few Knowns and the Many Unknowns
Frontiers in Integrative Neuroscience, 2021 Hundreds of messenger RNAs (mRNAs) are transported into neurites to provide templates for the assembly of local protein networks. These networks enable a neuron to configure different cellular domains for specialized functions.
Elsa C. Rodrigues +5 more
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Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. [PDF]
, 1997 Published ...
Cáceres, J. F. +14 more
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A mRNA and Cognate MicroRNAs Localize in the Nucleolus [PDF]
Nucleus, 2014 We previously discovered that a set of 5 microRNAs are concentrated in the nucleolus of rat myoblasts. We now report that several mRNAs are also localized in the nucleoli of these cells as determined by microarray analysis of RNA from purified nucleoli.
Reyes-Gutierrez, Pablo +2 more
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