Results 21 to 30 of about 463,726 (249)

FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons

eLife, 2021
Neurons rely on translation of synaptic mRNAs in order to generate activity-dependent changes in plasticity. Here, we develop a strategy combining compartment-specific crosslinking immunoprecipitation (CLIP) and translating ribosome affinity purification
Caryn R Hale, Kirsty Sawicka, Kevin Mora, John J Fak, Jin Joo Kang, Paula Cutrim, Katarzyna Cialowicz, Thomas S Carroll, Robert B Darnell   +8 more
doaj   +1 more source

Molecular mechanisms behind mRNA localization in axons [PDF]

Open Biology, 2020
Messenger RNA (mRNA) localization allows spatiotemporal regulation of the proteome at the subcellular level. This is observed in the axons of neurons, where mRNA localization is involved in regulating neuronal development and function by orchestrating ...
Benita Turner-Bridger, Cinzia Caterino, Jean-Michel Cioni   +2 more
doaj   +1 more source

Perceptions and practices of general practitioners on providing oral health care to people with diabetes - a qualitative study

BMC Family Practice, 2020
Background Poorly controlled diabetes leads to multiple complications including oral health problems. General practitioners (GPs) are at the forefront of management of chronic diseases in primary health care.
Prakash Poudel, Rhonda Griffiths, Vincent W. Wong, Amit Arora, Jeff R. Flack, Chee L. Khoo, Ajesh George   +6 more
doaj   +1 more source

Diversity on location

eLife, 2022
The RNA binding protein FMRP regulates the synthesis of synaptic and nuclear proteins within different compartments of a neuron.
Young J Yoon, Gary J Bassell
doaj   +1 more source

Oral health in residential aged care: Perceptions of nurses and management staff

Nursing Open, 2020
Aim This study aimed to explore the perceptions of residential aged care nursing and management staff regarding oral care, to develop strategies to improve the oral health of aged care residents. Design A qualitative approach was used.
Tiffany Patterson Norrie, Amy R. Villarosa, Ariana C. Kong, Sally Clark, Susan Macdonald, Ravi Srinivas, Jennifer Anlezark, Ajesh George   +7 more
doaj   +1 more source

Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions

Developmental Cell
Koppers M, Özkan N, Nguyen HH, Jurriens D, McCaughey J, Nguyen DTM, Li CH, Stucchi R, Altelaar M, MacGillavry HD, Kapitein LC, Hoogenraad CC, Farías GG.   +12 more
exaly   +2 more sources

Eating disorders and oral health: a scoping review on the role of dietitians

Journal of Eating Disorders, 2020
Background Compromised nutritional intake due to eating disorder related behaviors, such as binge eating and purging, can lead to multi-system medical complications, including an irreversible impact on oral health.
Tiffany Patterson-Norrie, Lucie Ramjan, Mariana S. Sousa, Lindy Sank, Ajesh George   +4 more
doaj   +1 more source

The effectiveness of guideline implementation strategies in the dental setting: a systematic review

Implementation Science, 2019
Background Guideline implementation has been an ongoing challenge in the dental practice setting. Despite this, there are no reviews summarising the existing evidence regarding effective guideline implementation strategies in this setting.
Amy R. Villarosa, Della Maneze, Lucie M. Ramjan, Ravi Srinivas, Michelle Camilleri, Ajesh George   +5 more
doaj   +1 more source

Novel Molecular Basis for Synapse Formation: Small Non-coding Vault RNA Functions as a Riboregulator of MEK1 to Modulate Synaptogenesis

Frontiers in Molecular Neuroscience, 2021
Small non-coding vault RNAs (vtRNAs) have been described as a component of the vault complex, a hollow-and-barrel-shaped ribonucleoprotein complex found in most eukaryotes.
Shuji Wakatsuki, Toshiyuki Araki
doaj   +1 more source

Locally translated mTOR controls axonal local translation in nerve injury [PDF]

Science, 2018
Local control of localized protein synthesis Localized protein synthesis provides spatiotemporal precision for injury responses and growth decisions at remote positions in nerve axons. Terenzio et al.
Marco Terenzio, Sandip Koley, Nitzan Samra, Ida Rishal, Qian Zhao, Pabitra K. Sahoo, Anatoly Urisman, Letizia Marvaldi, Juan A. Oses-Prieto, Craig Forester, Cynthia Gomes, Ashley L. Kalinski, Agostina Di Pizio, Ella Doron-Mandel, Rotem Ben-Tov Perry, Indrek Koppel, Jeffery L. Twiss, Alma L. Burlingame, Mike Fainzilber   +18 more
openaire   +5 more sources