Tracking and measuring local protein synthesis in vivo [PDF]
Development, 2021 ABSTRACT Detecting when and how much of a protein molecule is synthesized is important for understanding cell function, but current methods either cannot be performed in vivo or have poor temporal resolution. Here, we developed a technique to detect and quantify subcellular protein synthesis events in real time in vivo.
Ibrahim Kays, Brian E. Chen
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Local protein synthesis in neurons [PDF]
Current Biology, 2001 © 2001 Elsevier Science Ltd. Available online 26 November 2001.
Smith, W. Bryan +2 more
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A karyopherin acts in localized protein synthesis [PDF]
Cell Cycle, 2010 Multiple mechanisms are in place to regulate adequate synthesis of proteins, ranging from ways to ensure sequence fidelity, polypeptide folding and protein modification, to control of amounts and subcellular localization of the molecules. Some of these mechanisms act at the level of mRNA export and mRNA targeting.
Veenhoff, Liesbeth M. +2 more
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Synthesis and Localization of Pathogenesis-Related Proteins in Tobacco [PDF]
Molecular and Cellular Biology, 1987 The PR1 family of pathogenesis-related proteins from tobacco (Nicotiana tabacum L.) leaves is induced by a variety of pathogenic and chemical agents and is associated with resistance to tobacco mosaic virus. The majority of the PR1 proteins did not copurify with mesophyll protoplasts (the major cell type of the leaf) isolated from tobacco mosaic virus ...
J P, Carr +4 more
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The 89,000-Mr murine cytomegalovirus immediate-early protein stimulates c-fos expression and cellular DNA synthesis [PDF]
, 1988 The immediate-early (IE) genes of murine cytomegalovirus (MCMV) are expressed in the absence of prior viral protein synthesis and regulate the transcription of MCMV early genes. The effect of MCMV IE genes on growth induction was studied.
Pepperkok, Rainer +5 more
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Leveraging Affinity Interactions to Prolong Drug Delivery of Protein Therapeutics
Pharmaceutics, 2022 While peptide and protein therapeutics have made tremendous advances in clinical treatments over the past few decades, they have been largely hindered by their ability to be effectively delivered to patients. While bolus parenteral injections have become
Alan B. Dogan +2 more
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Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview [PDF]
, 2012 Translation or protein synthesis consists of a complex system of chemical reactions, which ultimately result in decoding of the mRNA and the production of a protein.
von der Haar, Tobias +1 more
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Immediate translation of Formin DIAPH1 mRNA after its exiting the nucleus is required for its perinuclear localization in fibroblasts. [PDF]
PLoS ONE, 2013 DIAPH1 is a formin protein which promotes actin polymerization, stabilizes microtubules and consequently is involved in cytoskeleton dynamics, cell migration and differentiation.
Guoning Liao, Gang Liu
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mRNA Trafficking and Local Protein Synthesis at the Synapse [PDF]
Neuron, 1999 The local delivery of mRNA and synthesis of proteins in dendrites provides a solution to the problem of synaptic heterogeneity (Figure 1Figure 1). Early work clearly demonstrating the presence of both mRNAs and polyribosomes in dendrites indicated the capacity for local translation.
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Bluetongue virus non-structural protein 1 is a positive regulator of viral protein synthesis. [PDF]
, 2012 BACKGROUND: Bluetongue virus (BTV) is a double-stranded RNA (dsRNA) virus of the Reoviridae family, which encodes its genes in ten linear dsRNA segments.
Roy Polly +8 more
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