Results 181 to 190 of about 76,244 (290)

Clinical and Imaging Characteristics of Parkinson's Disease with Negative Alpha‐Synuclein Seed Amplification Assay

Movement Disorders, EarlyView.
Abstract Background The cerebrospinal fluid alpha‐synuclein seed amplification assay (CSFasynSAA) detects alpha‐synuclein aggregation in over 90% of individuals with sporadic PD (sPD). However, the clinical characteristics of sPD with negative CSFasynSAA remain undefined.
Sarah M. Brooker, Jacopo Pasquini, Seung Ho Choi, David‐Erick Lafontant, Seyed‐Mohammad Fereshtehnejad, Yashar Zeighami, Piergiorgio Grillo, Giulietta M. Riboldi, Houman Azizi, Roqaie Moqadam, Un Jung Kang, Kelly N.H. Nudelman, Andrew Siderowf, Caroline M. Tanner, Thomas F. Tropea, Tatiana Foroud, Lana M. Chahine, Brit Mollenhauer, Kalpana M. Merchant, Douglas Galasko, Christopher S. Coffey, Roseanne D. Dobkin, Ethan G. Brown, Roy N. Alcalay, Daniel Weintraub, Kenneth Marek, Tanya Simuni, Paulina Gonzalez‐Latapi, Nicola Pavese, Kathleen L. Poston, the Parkinson's Progression Markers Initiative   +30 more
wiley   +1 more source

Aβ plaques induce local pre-synaptic toxicity in human iPSC-derived neuron xenografts. [PDF]

Stem Cell Reports
van Vierbergen JFM, Calatayud C, Balusu S, Carrano N, Peredo N, Vints K, Gallego SF, Horré K, De Strooper B, Verstreken P.   +9 more
europepmc   +1 more source

Increased Serum Neurofilament Light Chain Levels in Parkinson's Disease Patients Carrying the p.A53T SNCA Mutation: Data from the Parkinson's Progression Markers Initiative Study

Movement Disorders, EarlyView.
Abstract Background Serum neurofilament light chain (NfL) levels, a marker of axonal damage, are generally elevated in neurodegenerative conditions, but results in idiopathic Parkinson's disease (iPD) have been inconsistent. The p.A53T SNCA mutation usually leads to a severe form of PD.
Nikolaos Papagiannakis, Christos Koros, Athina‐Maria Simitsi, Leonidas Stefanis, and The Parkinson's Progression Markers Initiative, Kenneth Marek, Tanya Simuni, Andrew Siderowf, Caroline Tanner, Thomas F Tropea, Tatiana Foroud, Lana Chahine, Brit Mollenhauer, Kalpana Merchant, Douglas Galasko, Christopher Coffey, Kathleen Poston, Roseanne Dobkin, Ethan Brown, Roy Alcalay, Dan Weintraub, Emily Flagg, Kimberly Fabrizio, Susan Bressman, Cornelis Blauwendraat, Paola Casalin, Sonya Dumanis, Raymond James, Karl Kieburtz, Sneha Mantri, Werner Poewe, Michael Schwarzschild, John Seibyl, David Standaert, Duygu Tosun‐Turgut, Sohini Chowdhury, Jamie Eberling, Mark Frasier, Leslie Kirsch, Katie Kopil, Maggie Kuhl, Alyssa O'Grady, Todd Sherer, Tawny Willson, Tanya Simuni, Bridget McMahon, Craig Stanley, Kim Fabrizio, Dixie Ecklund, Christine Kohnen, Tatiana Foroud, Laura Heathers, Christopher Hobbick, John Seibyl, Christopher Coffey, Chelsea Caspell‐Garcia, Michael Brumm, Arthur Toga, Karen Crawford, Tatiana Foroud, Jan Hamer, Brit Mollenhauer, Doug Galasko, Kalpana Merchant, Andrew Singleton, Tatiana Foroud, Dirk Keene, Caroline Tanner, Ethan Brown, Carlie Tanner, Ethan Brown, Lana Chahine, Roseann Dobkin, Monica Korell, Neha Prakash, Tanya Simuni, Nabila Dahodwala, Caroline Tanner, Lana Chahine, Brit Mollenhauer, Sebastian Schade, Douglas Galasko, Anat Mirelman, Roy Alcalay, Katherine Leaver, Marie Saint‐Hilaire, Ruth Schneider, Christopher Tarolli, Werner Poewe, Aleksandar Videnovic, David Standaert, Marissa Dean, Sonja Jonsdottir, Rejko Krueger, Claire Pauly, Stewart Factor, Penelope Hogarth, Robert Hauser, Amy Amara, Michelle Fullard, Cyrus Zabetian, Hubert Fernandez, Kathrin Brockmann, Isabel Wurster, Yen Tai, Paolo Barone, Marina Picillo, Stuart Isaacson, Alberto Espay, Eduardo Tolosa, Javier Ruiz Martinez, Leonidas Stefanis, Kelvin Chou, Lorraine Kalia, Connie Marras, David Grimes, Tiago Mestre, Rajesh Pahwa, Mark Lew, Holly Shill, Shyamal Mehta, Giulietta Riboldi, Nikolaus McFarland, Ron Postuma, Zoltan Mari, David Ledingham, Nicola Pavese, Michele Hu, Norbert Brueggemann, Christine Klein, Bastiaan Bloem, Cristina Simonet, Alastair Noyce, Anette Janzen, David Pedrosa, Wolfgang Oertel, Njideka Okubadejo, David Shprecher, Arjun Tarakad, Emile Moukheiber, Joy Antala, Carla Aranda, Karen Williams, Sophia Melton, Karina Benson, Ashwini Ramachandran, Danielle Potts, Grace LaMoure, Ritikha Vengadesh, Ryan Manzler, Jaime Heller, Primi Ranola, Farah Kausar, Sherri Mosovsky, Diana Willeke, Elizabeth Kalinkara Gomez, Janelle Rodriguez, Nobuko Kemmotsu, May Eshel, Deborah Raymond, Abigail Desrosiers, Raymond James, Lauren Jackson, Iris Egner, Wesley Schlett, Courtney Blair, Lauren Ruffrage, Berenice Sevilla, Barbara Sommerfeld, Dustin Le, Erica Botting, Gabriella Mazur, Daniele Derlein, Evan Doll, Ying Liu, Ciera Cobb, Olivia Masiewicz, Jennifer Mule, Michael Morsillo, Ella Hilt, Aldazier Jakiran, Dominga Valentino, Lisbeth Pennente, Bobbie Stubbeman, Alicia Garrido, Valeria Ravasi, Ioana Croitoru, Christos Koros, Nikolas Papagiannakis, Frank Ferrari, Mengyu Zheng, Shawna Reddie, Alicia Alejandra, Andrea Gray, Alejandra Valenzuela, Caitlin Goodman, Sara Dresler, Neil Santos, Fahrial Esha, Kyle Rizer, Nadine Zablith, Liliana Dumitrescu, Debra Galley, Victoria Kate Foster, Jamil Razzaque, Madita Grümmer, Yara Krasowski, Natalie Donkor, Elisabeth Sittig, Oluwadamilola Ojo, Kelly Clark, Rory Mahabir, Kori Ribb, Shamera Willoughby   +213 more
wiley   +1 more source

Isogenic iPSC-derived <i>CTBP1</i> mutant neuronal cells exhibit neurodevelopmental defects. [PDF]

Front Neurosci
Lee S, Vijayalingam S, Klotz E, Dedert C, Xu F, Chinnadurai G, Ezekiel UR.   +6 more
europepmc   +1 more source

Clinically Feasible White Matter Fiber Tractography in Peritumoral Zones With Cerebral Vasogenic Edema

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose In diffusion MRI, vasogenic edema manifests as a major fraction of isotropic water that dilutes the anisotropic intra‐axonal portion of the signal. Many tractography algorithms mistake vasogenic edema for the white matter boundary and terminate tracking to prevent producing spurious streamlines.
Patryk Filipiak, Timothy M. Shepherd, Kamri Clarke, Gaia Ressa, Dimitris G. Placantonakis, Fernando E. Boada, Steven H. Baete   +6 more
wiley   +1 more source

APOE3 astrocytes can rescue lipid abnormalities and dystrophic neurites of APOE4 human neurons. [PDF]

PNAS Nexus
Halim DO, Di Biase E, Rajon A, Jordi L, Hallett PJ, Isacson O.   +5 more
europepmc   +1 more source

Modeling of Fiber Orientation‐Dependent R1 Relaxation in Human White Matter In Vivo Within The Framework of The Transient Hydrogen Bond Model

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Axon fiber orientation‐dependent R1 relaxation in human white matter (WM) in vivo at B0 = 1.5 T, 3 T, and 7 T was studied within the framework of the transient hydrogen bond (THB) model, which attributes MR signal relaxation to quantum magnetization interactions of water and motion‐restricted protons in hydrophilic heads of lipid ...
Dmitriy A. Yablonskiy, Risto A. Kauppinen, Ekaterina Paasonen, Jeromy Thotland, Mervi Könönen, Pramod Pisharady, Christophe Lenglet, Juhana M. Hakumäki, Olli H. J. Gröhn, Michael Garwood, Alexander L. Sukstanskii   +10 more
wiley   +1 more source

Laminin-conjugated aligned nanofiber yarns for topographical and biochemical guidance of neurite outgrowth and branching regulation. [PDF]

J Nanobiotechnology
Jia N, Yu L, Meng H, Liu S, Lin Z, Li T, Wang L, Huang W, Wu Y.   +8 more
europepmc   +1 more source

What Role Does the Central Nervous System Play in Refractory LUTS, and What Are the Therapeutic Implications? ICI‐RS 2025

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims While many patients with lower urinary tract symptoms (LUTS) improve by treating peripheral causes, a substantial proportion continue to experience symptoms despite apparently successful interventions. Central nervous system (CNS) mechanisms could potentially contribute to persisting symptoms after the initial peripheral cause has been ...
Mathijs M. de Rijk, Michel Wyndaele, Ana Charrua, Christopher Fry, Paul Abrams, Gommert A. van Koeveringe, Anthony J. Kanai, Marcus J. Drake   +7 more
wiley   +1 more source

Zolpidem restores sleep and decreases amyloid in a mouse model. [PDF]

Alzheimers Dement
Yu L, Yokomizo S, Doan TH, Zhao Q, Ganne A, Balasubramaniam M, Kastanenka KV.   +6 more
europepmc   +1 more source