Results 191 to 200 of about 76,244 (290)

Single‐Cell Nanodroplet Processing Proteomics Pipeline for Analysis of Human‐Derived Microglia

PROTEOMICS, EarlyView.
ABSTRACT Single‐cell omics tools provide unique insights into heterogeneous cell populations and their responses to stimuli. For example, single‐cell RNA sequencing has identified several transcriptionally distinct populations of microglia, which are resident immune cells of the central nervous system (CNS) that are responsive to CNS injury, infection,
Ashley N. Ives, James M. Fulcher, Alex R. Bautista, Reta Birhanu Kitata, Sarah M. Williams, David A. Bennett, Philip L. De Jager, Vladislav A. Petyuk   +7 more
wiley   +1 more source

Neurite branching is associated with mixed microtubule polarity in sea anemone neurons. [PDF]

J Exp Biol
Stone MC, Kothe GO, Jegla TJ, Rolls MM.
europepmc   +1 more source

Reduction in Synaptic Vesicle Protein Abundance but Increased Amounts of Nsg2 and Lpcat1 in Cerebral Cortices Without the Endosomal SNARE Proteins Vti1a and Vti1b

PROTEOMICS, EarlyView.
ABSTRACT Absence of the endosomal SNAREs vti1a and vti1b results in perinatal death and severe neuronal phenotypes in mice, while lack of one of these proteins results in minor phenotypes. Proteomic differences were investigated to obtain a deeper insight into processes in which vti1a and vti1b are involved.
Julia Gottschalk, Katharina Kotschnew, Julia Hahn, Thomas Patschkowski, Gabriele von Fischer von Mollard   +4 more
wiley   +1 more source

Emergence of clustered synapses during the development of a nervous system. [PDF]

BMC Biol
Balshayi Y, Bokman E, Zaslaver A.
europepmc   +1 more source

Monolithic 3D Nanoelectrode Arrays on CMOS Circuitry for Scalable, High‐Resolution Neural Recording

Small, EarlyView.
A CMOS‐integrated in vitro electrophysiology platform with 26,400 3D nanoelectrodes enables high‐resolution extracellular recordings with enhanced spatial sensitivity. Wafer‐scale, low‐temperature post‐fabrication monolithic integration of nanoelectrodes on foundry‐made CMOS chips preserves circuit functionality and electrical performance.
Aziliz Lecomte, Laurent Mazenq, Marie‐Charline Blatché, Aurélie Lecestre, Guilhem Larrieu   +4 more
wiley   +1 more source

Disease modeling of myocilin mutation-dependent normal tension glaucoma: human retinal ganglion cell susceptibility to unfolded protein response and mTOR signaling. [PDF]

Stem Cells
Shil SK, Subramani M, Van Hook MJ, Qiu F, Ahmad I.   +4 more
europepmc   +1 more source

Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development

Environmental Toxicology, EarlyView.
ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo, Patricia Meade, Irene Jiménez‐Salvador, Carmen Hernández‐Ainsa, Eldris Iglesias, Alba Pesini, Nuria Garrido‐Pérez, Sonia Emperador, David Pacheu‐Grau, Pilar Bayona‐Bafaluy, Eduardo Ruiz‐Pesini   +10 more
wiley   +1 more source

NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons. [PDF]

J Neuroinflammation
Wang S, Barry AM, Lee YK, Young N, Shim SW, Wang X, Kim H, Stirling-Barros L, González-Cano R, Costigan M, Baskozos G, Rinaldi S, Bennett DL, Oh SB, Davies AJ.   +14 more
europepmc   +1 more source

A thermoplastic microfluidic platform with integrated electrospun scaffolds for assessing brain cell‐specific drug selectivity

VIEW, EarlyView.
Schematic representation of the microfluidic platform with its advantages. Abstract A major challenge in pharmacology is the limited selectivity of therapeutic compounds toward specific tissues or cells. Drugs often distribute systemically before reaching the intended site of action, affecting nontarget cells and potentially reducing efficacy or ...
Maria Testa, Laura Palumbo, Martina La Rosa, Antonella Girgenti, Fabio Salvatore Palumbo, Pasquale Picone, Francesco Lopresti, Domenico Nuzzo, Vincenzo La Carruba   +8 more
wiley   +1 more source

A primary neuron culture system for functional studies of anoxia tolerance in turtles. [PDF]

J Exp Biol
Schneider NA, Riggs CL, Warmka M, Hofheins S, Smith C, Warren DE.   +5 more
europepmc   +1 more source