Results 41 to 50 of about 658,405 (249)

Neuro-muscular block induced by intravascular injection of cobalt

, 1966
O artigo apresenta resumo em inglês.In this paper, the authors studied the effect of the cobalt ion injected by the intravascular route. The cation determined neuro muscular block. In all the animals the direct stimuli still evoked a muscular contraction.
Moraes, Sérgio de, Carvalho, Fernando Varela de   +1 more
core   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Optimizing transport methods to preserve function of self‐innervating muscle cells for laryngeal injection

Laryngoscope Investigative Otolaryngology
Objectives Recently, our laboratory has discovered a self‐innervating population of muscle cells, called motor endplate‐expressing cells (MEEs). The cells innately release a wide variety of neurotrophic factors into the microenvironment promoting ...
Samuel L. Kaefer, Lujuan Zhang, Sarah Brookes, Rachel A. Morrison, Sherry Voytik‐Harbin, Stacey Halum   +5 more
doaj   +1 more source

Three Distinct Mechanisms of Neuro-Muscular Junction Excitation by Infrared Pulses [PDF]

Biophysical Journal, 2012
Post-synaptic currents (PSCs) were recorded using whole cell voltage clamp to examine excitatory responses of the neuro-muscular junction to infrared pulses (1862nm, 200μs/pulse, 5-30 pulses/s, 20-1000 μJ/pulse over 125 nm2). In wild type Caenorhabditis elegans, optical stimuli excited the post-synaptic cell by 1) immediate opto-mechanical triggering ...
Liu, Qiang, Jorgensen, Erik M., Holman, Holly A., Rawson, Randi, Rabbitt, Richard D.   +4 more
openaire   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Investigating Effects of eugenol on nerve conduction and synaptic transmission at neuromuscular junction in an amphibian

Impulse: The Premier Undergraduate Neuroscience Journal, 2019
Eugenol is a natural anesthetic. This study provides insights into how eugenol affects neuro- muscular communication in a vertebrate to address its anesthetic property.
Christa M. Saelinger, Micaiah C. McNabb, Sheyanne Trent, Melody Danley, Robin Cooper   +4 more
doaj  

Pharmacological profile of ionotropic glutamate receptors in the fly neuro-muscular junction [PDF]

Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 2009
The action of series of pharmacological agents (agonists and competitive antagonists, allosteric modulators and channel blockers) was studied on the neuro-muscular junction of the fly Calliphora vicina larvae. The end-plate currents were evoked by nerve stimulation and recorded by conventional two-electrode voltage clamp. Properties of the ion channels
I. M. Fedorova, L. G. Magazanik, D. B. Tikhonov   +2 more
openaire   +1 more source

An autopsy study of a familial oculopharyngeal muscular dystrophy (OPMD) with distal spread and neurogenic involvement [PDF]

, 1981
An 81-year-old man from a family with a history of oculopharyngeal muscular dystrophy (OPMD) involving 6 members over 4 generations is described. The patient first noted drooping of his eyelids at the age of 65.
Krause, Klaus-Henning, Schmitt, H.-P.
core   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source