Results 101 to 110 of about 268,028 (214)

Natural Killer-Derived Exosomal miR-186 Inhibits Neuroblastoma Growth and Immune Escape Mechanisms.

Cancer Research, 2018
In neuroblastoma, the interplay between immune cells of the tumor microenvironment and cancer cells contributes to immune escape mechanisms and drug resistance.
P. Neviani, Petra M Wise, M. Murtadha, C. Liu, Chun-Hua Wu, A. Jong, R. Seeger, M. Fabbri   +7 more
semanticscholar   +1 more source

Repurposing disulfiram, an alcohol-abuse drug, in neuroblastoma causes KAT2A downregulation and in vivo activity with a water/oil emulsion

Scientific Reports, 2023
Neuroblastoma, the most common type of pediatric extracranial solid tumor, causes 10% of childhood cancer deaths. Despite intensive multimodal treatment, the outcomes of high-risk neuroblastoma remain poor.
Annie Beaudry, Simon Jacques-Ricard, Anaïs Darracq, Nicolas Sgarioto, Araceli Garcia, Teresita Rode García, William Lemieux, Kathie Béland, Elie Haddad, Paulo Cordeiro, Michel Duval, Serge McGraw, Chantal Richer, Maxime Caron, François Marois, Pascal St-Onge, Daniel Sinnett, Xavier Banquy, Noël J.-M. Raynal   +18 more
doaj   +1 more source

Eradication of Neuroblastoma by T Cells Redirected with an Optimized GD2-Specific Chimeric Antigen Receptor and Interleukin-15

Clinical Cancer Research, 2019
Purpose: A delay in encountering the cognate antigen while in the circulation, and the suboptimal costimulation received at the tumor site are key reasons for the limited activity of chimeric antigen receptor–redirected T cells (CAR-T) in solid tumors ...
Yuhui Chen, Chuang Sun, Elisa Landoni, L. Metelitsa, G. Dotti, B. Savoldo   +5 more
semanticscholar   +1 more source

MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors [PDF]

, 2018
MRE11 is a component of the MRE11/RAD50/NBS1 (MRN) complex, whose activity is essential to control faithful DNA replication and to prevent accumulation of deleterious DNA double-strand breaks.
Bartolazzi, Armando, Belardinilli, Francesca, Capalbo, Carlo, Cardinali, Beatrice, Colicchia, Valeria, Comes Franchini, Mauro, Coppa, Anna, Di Giulio, Stefano, Di Marcotullio, Lucia, Fabretti, Francesca, Giannini, Giuseppe, Gulino, Alberto, Infante, Paola, Locatelli, Erica, Petricci, Elena, Petroni, Marialaura, Sahùn Roncero, Maria, Sardina, Francesca, Soddu, Silvia, Tessitore, Alessandra   +19 more
core   +3 more sources

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

Nature Genetics, 2018
Childhood high-risk neuroblastomas with MYCN gene amplification are difficult to treat effectively1. This has focused attention on tumor-specific gene dependencies that underlie tumorigenesis and thus provide valuable targets for the development of novel
Adam D. Durbin, Mark W. Zimmerman, N. Dharia, B. Abraham, A. Iniguez, Nina Weichert-Leahey, Shuning He, J. Krill-Burger, D. Root, F. Vazquez, Aviad Tsherniak, W. Hahn, T. Golub, R. Young, A. Look, K. Stegmaier   +15 more
semanticscholar   +1 more source

Olfactory Neuroblastoma: Diagnostic Difficulty [PDF]

, 2011
Olfactory neuroblastoma is an uncommon malignant tumor of sinonasal tract arising from the olfactory neuro epithelium. The olfactory neuroblastomas presenting with divergent histomorphologies like, epithelial appearance of cells, lacking a neuro ...
Biswas, Siddhartha, MN, Vidya, S, Vijay Shankar, Shivakumar, Swarna   +3 more
core   +1 more source

Anesthetic management of an infant with giant abdominal neuroblastoma

Brazilian Journal of Anesthesiology, 2017
Neuroblastoma is the most common, non-central nervous system tumor of childhood. It has the potential to synthesize catecholamines. However, the presences of hypertension are uncommon.
Manuel Ángel Gómez-Ríos, Federico Curt Nuño, Purísima Barreto-Calvo   +2 more
doaj  

Magnetic hyperthermia enhances cell toxicity with respect to exogenous heating [PDF]

, 2016
Magnetic hyperthermia is a new type of cancer treatment designed for overcoming resistance to chemotherapy during the treatment of solid, inaccessible human tumors. The main challenge of this technology is increasing the local tumoral temperature with minimal side effects on the surrounding healthy tissue.
arxiv   +1 more source

Congenital neuroblastoma [PDF]

, 2013
A 3-day-old baby girl was noted to have abnormal posture and paucity of movement of the left foot. Examination revealed flaccid weakness of the left lower limb. The rest of the neurological examination was normal.
Mintoff, Dillon, Mizzi, Christine
core  

Nifurtimox Is Effective Against Neural Tumor Cells and Is Synergistic with Buthionine Sulfoximine. [PDF]

, 2016
Children with aggressive neural tumors have poor survival rates and novel therapies are needed. Previous studies have identified nifurtimox and buthionine sulfoximine (BSO) as effective agents in children with neuroblastoma and medulloblastoma.
Du, Michael, Scorsone, Kathleen A, Woodfield, Sarah E, Zage, Peter E, Zhang, Linna   +4 more
core   +1 more source