Results 101 to 110 of about 345,011 (339)

Emerging Neuroblastoma 3D In Vitro Models for Pre-Clinical Assessments

Frontiers in Immunology, 2020
The potential of tumor three-dimensional (3D) in vitro models for the validation of existing or novel anti-cancer therapies has been largely recognized.
Diana Corallo, Stella Frabetti, Olivia Candini, Elisa Gregianin, Massimo Dominici, Massimo Dominici, Horst Fischer, Sanja Aveic, Sanja Aveic   +8 more
doaj   +1 more source

Epigenetic therapies for neuroblastoma: immunogenicity awakens

Molecular Oncology, 2023
The development of immunotherapies for neuroblastoma remains challenging owing to the low immunogenicity of neuroblastoma cells, as reflected by the low expression of one of the main triggers of immune recognition, the major histocompatibility complex ...
Carlos Jiménez, Lucas Moreno, Miguel F. Segura   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Identifying Molecular Probes for Fluorescence-Guided Surgery in Neuroblastoma: A Systematic Review

Children
Background/Objectives: Targeted and non-targeted fluorescent molecular probes (FMPs) can be used intra-operatively to visualise tumour tissue. Multiple probes have been clinically approved for fluorescence-guided surgery (FGS) in adult oncology, and the ...
Megan Hennessy, Jonathan J. Neville, Laura Privitera, Adam Sedgwick, John Anderson, Stefano Giuliani   +5 more
doaj   +1 more source

Nifurtimox Is Effective Against Neural Tumor Cells and Is Synergistic with Buthionine Sulfoximine. [PDF]

, 2016
Children with aggressive neural tumors have poor survival rates and novel therapies are needed. Previous studies have identified nifurtimox and buthionine sulfoximine (BSO) as effective agents in children with neuroblastoma and medulloblastoma.
Du, Michael, Scorsone, Kathleen A, Woodfield, Sarah E, Zage, Peter E, Zhang, Linna   +4 more
core   +1 more source

Tumor to normal single cell mRNA comparisons reveal a pan-neuroblastoma cancer cell

bioRxiv, 2020
Neuroblastoma is a childhood cancer that resembles developmental stages of the neural crest. It is not established what developmental processes neuroblastoma cancer cells represent. Here, we sought to reveal the phenotype of neuroblastoma cancer cells by
Gerda Kildisiute, Waleed M. Kholosy, Matthew D. Young, Kenny Roberts, R. Elmentaite, Sander R van Hooff, Clarissa N. Pacyna, Eleonora Khabirova, Alice Piapi, Christine Thevanesan, E. B. Blanco, Christina Burke, L. Mamanova, Kaylee M. Keller, K. Langenberg-Ververgaert, P. Lijnzaad, T. Margaritis, F. Holstege, Michelle L. Tas, M. Wijnen, Max M. van Noesel, I. del Valle, G. Barone, Reinier van der Linden, C. Duncan, John Anderson, J. Achermann, M. Haniffa, S. Teichmann, D. Rampling, N. Sebire, Xiaoling He, R. D. de Krijger, R. Barker, K. Meyer, O. Bayraktar, K. Straathof, J. Molenaar, S. Behjati   +38 more
semanticscholar   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

NEUROBLASTOMA IN ADULT: CASE REPORT AND LITERATURE REVIEW

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2018
Neuroblastoma is a malignant tumor derived from the neuroblasts of the sympathetic nervous system, which develop in any region of the nervous system. Usually, neuroblastoma is detected in children aged 1–2 years.
E. A. Skorniakova, L. G. Zaslavskii, N. A. Neofidov, S. L. Vorobev, A. A. Gotovchikov, O. V. Rodionova, A. G. Kovelenov, O. L. Zaslavskaia   +7 more
doaj   +1 more source

The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation

Cell Adhesion & Migration, 2021
Neuroblastoma is a highly metastatic tumor that emerges from neural crest cell progenitors. Focal Adhesion Kinase (FAK) is a regulator of cell migration that binds to the receptor Neogenin-1 and is upregulated in neuroblastoma.
Andrea A. Villanueva, Pilar Sanchez-Gomez, Ernesto Muñoz-Palma, Sofía Puvogel, Bárbara S. Casas, Cecilia Arriagada, Isaac Peña-Villalobos, Pablo Lois, Manuel Ramírez Orellana, Fabiana Lubieniecki, Fernando Casco Claro, Iván Gallegos, Javier García-Castro, Vicente A. Torres, Verónica Palma   +14 more
doaj   +1 more source

A novel and universal method for microRNA RT-qPCR data normalization [PDF]

, 2009
Gene expression analysis of microRNA molecules is becoming increasingly important. In this study we assess the use of the mean expression value of all expressed microRNAs in a given sample as a normalization factor for microRNA real-time quantitative PCR
De Weer, An, Mestdagh, Pieter, Muth, Daniel, Speleman, Franki, Van Vlierberghe, Pieter, Vandesompele, Jo, Westermann, Frank   +6 more
core   +2 more sources