Results 121 to 130 of about 268,028 (214)

Integration of Gene Expression Data and Methylation Reveals Genetic Networks for Glioblastoma [PDF]

arXiv, 2015
Motivation: The consistent amount of different types of omics data requires novel methods of analysis and data integration. In this work we describe Regression2Net, a computational approach to analyse gene expression and methylation profiles via regression analysis and network-based techniques.
arxiv  

High-Risk Neuroblastoma Treatment Review

Children, 2018
Neuroblastoma is the most common extracranial solid tumor in children. One subset, high-risk neuroblastoma, is very difficult to treat and requires multi-modal therapy.
Valeria R Smith, J. Foster
semanticscholar   +1 more source

NEUROBLASTOMA IN ADULT: CASE REPORT AND LITERATURE REVIEW

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2018
Neuroblastoma is a malignant tumor derived from the neuroblasts of the sympathetic nervous system, which develop in any region of the nervous system. Usually, neuroblastoma is detected in children aged 1–2 years.
E. A. Skorniakova, L. G. Zaslavskii, N. A. Neofidov, S. L. Vorobev, A. A. Gotovchikov, O. V. Rodionova, A. G. Kovelenov, O. L. Zaslavskaia   +7 more
doaj   +1 more source

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line.

Journal of Visualized Experiments, 2016
Having appropriate in vivo and in vitro systems that provide translational models for human disease is an integral aspect of research in neurobiology and the neurosciences.
Mackenzie M. Shipley, Colleen A. Mangold, Moriah L. Szpara   +2 more
semanticscholar   +1 more source

How to target apoptosis signaling pathways for the treatment of pediatric cancers [PDF]

, 2013
Apoptosis represents one of the most important forms of cell death in higher organisms and is typically dysregulated in human cancers, including pediatric tumors.
Fulda, Simone
core   +2 more sources

Modeling cell differentiation in neuroblastoma: insights into development, malignancy, and treatment relapse [PDF]

arXiv
Neuroblastoma is a paediatric extracranial solid cancer that arises from the developing sympathetic nervous system and is characterised by an abnormal distribution of cell types in tumours compared to healthy infant tissues. In this paper, we propose a new mathematical model of cell differentiation during sympathoadrenal development.
arxiv  

Simultaneous Measurement of Neural Spike Recordings and Multi-Photon Calcium Imaging in Neuroblastoma Cells

Sensors, 2012
This paper proposes the design and implementation of a micro-electrode array (MEA) for neuroblastoma cell culturing. It also explains the implementation of a multi-photon microscope (MPM) customized for neuroblastoma cell excitation and imaging under ...
Jeehyun Kim, Shinwon Kang, Juyeong Baek, Unsang Jung, Suhwan Kim   +4 more
doaj   +1 more source

Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma

Science Translational Medicine, 2019
MYCN regulates polyamines in neuroblastoma, and combined inhibition of polyamine synthesis and transport has therapeutic effects in mouse models.
Laura D. Gamble, S. Purgato, Jayne E. Murray, Lin Xiao, Denise M. T. Yu, Kimberley M. Hanssen, F. Giorgi, Daniel R. Carter, A. Gifford, E. Valli, G. Milazzo, Alvin Kamili, Chelsea Mayoh, Bing Liu, G. Eden, Sara Sarraf, Sophie Allan, S. Di Giacomo, C. Flemming, A. Russell, B. Cheung, A. Oberthuer, W. London, M. Fischer, T. Trahair, J. Fletcher, G. Marshall, D. Ziegler, M. Hogarty, M. Burns, G. Perini, M. Norris, M. Haber   +32 more
semanticscholar   +1 more source

Activated β-catenin Forces N2A Cell-derived Neurons Back to Tumor-like Neuroblasts and Positively Correlates with a Risk for Human Neuroblastoma

International Journal of Biological Sciences, 2012
Neuroblastoma is an embryonic malignancy arising from neuroblasts. The mechanisms that regulate the origination of neuroblastoma are still not very clear.
Feng Zhi, Guangming Gong, Yan Xu, Yan Zhu, Die Hu, Yilin Yang, Yiqiao Hu
doaj  

The Evolution of Risk Classification for Neuroblastoma

Children, 2019
Neuroblastoma is a tumor with great clinical heterogeneity. Patients in North America are risk-stratified using a number of features including age at diagnosis, disease stage, tumor histology, MYCN status (amplified versus nonamplified), and tumor cell ...
Elizabeth A. Sokol, A. Desai
semanticscholar   +1 more source