Results 311 to 320 of about 345,011 (339)

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

HMMR has oncoprotein-like properties in neuroblastoma cells and high HMMR expression has independent prognostic potential in neuroblastomas. [PDF]

Sci Rep
Karapouliou C, Faizul EM, Rajeeve V, Cutillas PR, Stoker AW.   +4 more
europepmc   +1 more source

Figure S3 from Long-Lasting Response to Lorlatinib in Patients with ALK-Driven Relapsed or Refractory Neuroblastoma Monitored with Circulating Tumor DNA Analysis

Torben Ek, Raghda R. Ibrahim, Hartmut Vogt, Kleopatra Georgantzi, Catarina Träger, Jennie Gaarder, Anna Djos, Ida Rahmqvist, Elisabeth Mellström, Fani Pujol-Calderón, Christoffer Vannas, Lina Hansson, Henrik Fagman, Diana Treis, Susanne Fransson, Tobias Österlund, Tzu‐Po Chuang, Bronte Manouk Verhoeven, Anders Ståhlberg, Ruth H. Palmer, Bengt Hallberg, Tommy Martinsson, Per Kogner, Martin G. Dalin   +23 more
openalex   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Copy-Number Aberrations in Circulating Tumor DNA Enable Diagnosis and Risk Stratification of Pediatric Neuroblastic Tumors. [PDF]

Cancer Res Commun
Tao T, Cai J, Tang Y, Lu D, Zhang L, Peng J, Wang Y, Gu W, Zhang S, Wang J.   +9 more
europepmc   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

A constitutional translocation T(1;17)(P36.2;Q11.2) in a neuroblastoma patient disrupts NBPF1, a novel putative tumor suppressor gene [PDF]

, 2008
Andries, Vanessa, Staes, Katrien, Van Roy, Frans, Vandepoele, Karl   +3 more
core   +1 more source

Covalent Peptide‐Based N‐Myc/Aurora‐A Inhibitors Bearing Sulfonyl Fluoride Warheads

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
N‐Myc‐derived peptidomimetics bearing aryl sulfonyl fluoride warheads were shown to act as effective N‐Myc/Aurora‐A PPI inhibitors, selectively labelling Aurora‐A in a recognition‐directed manner. ABSTRACT Orthosteric inhibition of the N‐Myc/Aurora‐A protein–protein interaction (PPI) represents a potential mechanism by which degradation of N‐Myc can be
Robert S. Dawber, Diana Gimenez, George W. Preston, Megan H. Wright, Richard Bayliss, Stuart L. Warriner, Andrew J. Wilson   +6 more
wiley   +1 more source

Integrative Multiomics and Drug Sensitivity Profiling Reveal Potential Biomarkers and Therapeutic Strategies in Pediatric Solid Tumors. [PDF]

Cancer Res
ElHarouni D, Hernansaiz-Ballesteros R, Peterziel H, Balasubramanian GP, Previti C, Schramm K, Blattner-Johnson M, Kabbe R, Jones BC, Oppermann S, Jones DTW, Pfister SM, Witt O, Saez-Rodriguez J, Oehme I, Jäger N, Schlesner M.   +16 more
europepmc   +1 more source