Results 41 to 50 of about 185,865 (259)
, 2017 Neuroblastoma is characterized by a wide range of clinical manifestations and associated with poor prognosis when there is amplification of MYCN oncogene or high expression of Myc oncoproteins.
Huang, Chao-Cheng;Wang, Shuo-Yu;Lin, Li-Ling;Wang, Pei-Wen;Chen, Ting-Ya;Hsu, Wen-Ming;Lin, Tsu-Kung;Liou, Chia-Wei;Chuang, Jiin-Haur +1 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann +8 more
wiley +1 more source
Applications and prospects of targeted therapy for neuroblastoma
World Journal of Pediatric Surgery, 2020 Background Neuroblastoma is an extremely malignant tumor in children. For advanced or recurrent cases, existing treatment modalities are limited and efficacy remains disappointing.
Jing Wang, Kai Li, Wei Yao
doaj +1 more source
An evaluation of the Agrobacterium tumefaciens Virulence gene system as a potential diagnostic test for Neuroblastoma. [PDF]
, 1993 Neuroblastoma is a common pediatric cancer, the prognosis for which is markedly dependent upon the progression of the disease at the time of diagnosis.
Palmer, Adrian Charles Vernon
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Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari +5 more
wiley +1 more source
Frontiers in Molecular Neuroscience, 2019 Long non-coding RNAs (lncRNAs) have emerged as an important regulatory control in biological systems. Though the field of lncRNA has been progressing rapidly, a complete understanding of the role of lncRNAs in neuroblastoma pathogenesis is still lacking.
Bharat Prajapati +6 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Dissecting the Reciprocal Influence between Cancer Cells and Fibroblasts in Pediatric Neuroblastoma
, 2023 reservedNeuroblastoma, the most prevalent extracranial tumor in pediatric patients, arises from the malignant transformation of neural crest progenitors within the peripheral sympathetic nervous system.
NARDELLI, CRISTINA
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Molecular and genetic studies in high-risk neuroblastoma [PDF]
, 2021 Neuroblastoma is the most common and deadly cancer in the first year of life. Children with high-risk neuroblastoma have a very poor prognosis, despite heavy multimodal treatment, with less than 50% of 5 years of overall survival.
Martinez-Monleon, Angela
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source