Results 41 to 50 of about 283,064 (357)

Patient-derived models: Advanced tools for precision medicine in neuroblastoma

Frontiers in Oncology, 2023
Neuroblastoma is a childhood cancer derived from the sympathetic nervous system. High-risk neuroblastoma patients have a poor overall survival and account for ~15% of childhood cancer deaths.
Kristina Aaltonen, Katarzyna Radke, Aleksandra Adamska, Alexandra Seger, Adriana Mañas, Daniel Bexell   +5 more
doaj   +1 more source

Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link [PDF]

, 2011
The proteasome inhibitor Bortezomib has been identified as a potent enhancer of TRAIL-induced apoptosis in several human cancers. However, the identification of the underlying molecular mechanisms of this synergistic cell death induction has been ongoing
Fulda, Simone
core   +1 more source

miR‐100 rs1834306 a > G polymorphism decreases neuroblastoma risk in Chinese children

Cancer Reports, 2023
Background Neuroblastoma is a common malignant tumor stemming from the sympathetic nervous system in children, which is often life‐threatening. The genetics of neuroblastoma remains unclear. Studies have shown that miRNAs participate in the regulation of
Yufeng Han, Jiaming Chang, Lei Lin, Chunlei Zhou, Jinhong Zhu, Haiyan Wu, Jing He, Wen Fu   +7 more
doaj   +1 more source

Anti-GD2 antibody and Vorinostat immunocombination therapy is highly effective in an aggressive orthotopic neuroblastoma model

OncoImmunology, 2020
Neuroblastoma is a childhood malignancy and in the majority of patients, the primary tumor arises in one of the adrenal glands. Neuroblastoma cells highly express the disialoganglioside GD2, which is the primary target for the development of ...
Renske J. E. van den Bijgaart, Michiel Kroesen, Ingrid C. Brok, Daphne Reijnen, Melissa Wassink, Louis Boon, Peter M. Hoogerbrugge, Gosse J Adema   +7 more
doaj   +1 more source

Integrating Bulk-seq and Single-cell-seq Reveals Estrogen and MAPK Pathways Associating with Neuroblastoma Outcome

Cancer Control, 2023
Introduction Neuroblastoma is the most common extracranial solid tumor in children. Patients with high-risk neuroblastoma have a 5-year survival rate less than 50% after extensive treatment. Signaling pathways control cell fate decisions that dictate the
Xin Li, Yanlong Zheng, Qiao Ge, Zhenbo Dai, Dejun Zhou, Xiangdong Tian   +5 more
doaj   +1 more source

Novel Therapies for Relapsed and Refractory Neuroblastoma

Children, 2018
While recent increases in our understanding of the biology of neuroblastoma have allowed for more precise risk stratification and improved outcomes for many patients, children with high-risk neuroblastoma continue to suffer from frequent disease relapse,
Peter E. Zage
doaj   +1 more source

Positional and functional mapping of a neuroblastoma differentiation gene on chromosome 11 [PDF]

, 2005
Background: Loss of chromosome 11q defines a subset of high-stage aggressive neuroblastomas. Deletions are typically large and mapping efforts have thus far not lead to a well defined consensus region, which hampers the identification of positional ...
De Preter, K, Vandesompele, J, Menten, B, Carr, P, Fiegler, H, Edsjö, Anders,, Carter, NP, Yigit, N, Waelput, W, Van Roy, N, Bader, S, Påhlman, Sven,, Speleman, F, Lund University.   +13 more
core   +3 more sources

Inhibition of Poly(ADP-Ribose) polymerase enhances the toxicity of 131I-Metaiodobenzylguanidine/Topotecan combination therapy to cells and xenografts that express the noradrenaline transporter [PDF]

, 2012
Targeted radiotherapy using [131I]meta-iodobenzylguanidine ([131I]MIBG) has produced remissions in some neuroblastoma patients. We previously reported that combining [131I]MIBG with the topoisomerase I (Topo-I) inhibitor topotecan induced long-term DNA ...
Babich, John W, Boyd, Marie, Champion, Sue, Gaze, Mark N, Mairs, Robert J, McCluskey, Anthony G, Pimlott, Sally L, Tesson, Mathias   +7 more
core   +1 more source

Exploring the Role of Fibroblasts in Promoting Neuroblastoma Cell Migration and Invasion

Journal of Nanotheranostics
Neuroblastoma, the most common pediatric extracranial solid tumor, arises from the malignant transformation of neural crest progenitors in the peripheral nervous system.
Diana Corallo, Cristina Nardelli, Marcella Pantile, Sara Menegazzo, Alessandra Biffi, Sanja Aveic   +5 more
doaj   +1 more source

Genetic variation associated with childhood and adult stature and risk of MYCN‐amplified neuroblastoma

Cancer Medicine, 2020
Background Neuroblastoma is the most common pediatric solid tumor. MYCN‐amplification is an important negative prognostic indicator and inherited genetic contributions to risk are incompletely understood.
Eleanor C. Semmes, Erica Shen, Jennifer L. Cohen, Chenan Zhang, Qingyi Wei, Jillian H. Hurst, Kyle M. Walsh   +6 more
doaj   +1 more source