Results 21 to 30 of about 137,730 (260)
BMC Pediatrics, 2021 Background MYCN amplification and age are two critical prognostic factors of pediatric neuroblastoma. Previously, we had revealed the prognosis of MYCN target genes.
Haiwei Wang +4 more
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AKT inhibitor Hu7691 induces differentiation of neuroblastoma cells
Acta Pharmaceutica Sinica B, 2023 While neuroblastoma accounts for 15% of childhood tumor-related deaths, treatments against neuroblastoma remain scarce and mainly consist of cytotoxic chemotherapeutic drugs.
Shaowei Bing +12 more
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Journal of Experimental & Clinical Cancer Research, 2023 Background The repressor element-1 silencing transcription factor (REST), a master transcriptional repressor, is essential for maintenance, self-renewal, and differentiation in neuroblastoma.
Janardhan Keshav Karapurkar +9 more
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Autophagy inhibition improves the cytotoxic effects of receptor tyrosine kinase inhibitors
Cancer Cell International, 2018 Background A growing field of evidence suggests the involvement of oncogenic receptor tyrosine kinases (RTKs) in cell transformation. Deregulated activity of RTKs in tumors can determine disease progression and therapeutic responses in several types of ...
Sanja Aveic +7 more
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BMC Pediatrics, 2022 Background Previously, we had analyzed the prognosis of E2F transcription factors across adult tumor types. However, the expressions and prognosis of E2F transcription factors in pediatric neuroblastoma have not yet been fully studied.
Haiwei Wang +3 more
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Seminars in Pediatric Surgery, 2010 Neuroblastoma is a heterogeneous disease; tumors can spontaneously regress or mature, or display an aggressive, therapy-resistant phenotype. Increasing evidence indicates that the biological and molecular features of neuroblastoma significantly influence and are highly predictive of clinical behavior.
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Patient-derived organoids (PDOs) as a novel in vitro model for neuroblastoma tumours
BMC Cancer, 2019 Background Neuroblastoma (NB) is a paediatric tumour of the sympathetic nervous system. Half of all cases are defined high-risk with an overall survival less than 40% at 5 years from diagnosis.
P. Fusco +13 more
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RTEL1 gene polymorphisms and neuroblastoma risk in Chinese children
BMC Cancer, 2023 Background Neuroblastoma, a neuroendocrine tumor originating from the sympathetic ganglia, is one of the most common malignancies in childhood. RTEL1 is critical in many fundamental cellular processes, such as DNA replication, DNA damage repair, genomic ...
Ting Zhang +5 more
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Japanese Journal of Clinical Oncology, 2018 Neuroblastoma is one of the most common solid tumors in children and has a diverse clinical behavior that largely depends on the tumor biology. Neuroblastoma exhibits unique features, such as early age of onset, high frequency of metastatic disease at diagnosis in patients over 1 year of age and the tendency for spontaneous regression of tumors in ...
Akira, Nakagawara +5 more
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EZH2 inhibition decreases neuroblastoma proliferation and in vivo tumor growth.
PLoS ONE, 2021 Investigation of the mechanisms responsible for aggressive neuroblastoma and its poor prognosis is critical to identify novel therapeutic targets and improve survival.
Laura V Bownes +11 more
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