Results 31 to 40 of about 185,865 (259)

miR‐100 rs1834306 a > G polymorphism decreases neuroblastoma risk in Chinese children

Cancer Reports, 2023
Background Neuroblastoma is a common malignant tumor stemming from the sympathetic nervous system in children, which is often life‐threatening. The genetics of neuroblastoma remains unclear. Studies have shown that miRNAs participate in the regulation of
Yufeng Han, Jiaming Chang, Lei Lin, Chunlei Zhou, Jinhong Zhu, Haiyan Wu, Jing He, Wen Fu   +7 more
doaj   +1 more source

Pyroptosis-Related Gene Signature Predicts the Prognosis and Immune Infiltration in Neuroblastoma

Frontiers in Genetics, 2022
Neuroblastoma is the most common pediatric extracranial solid tumor. The 5-year survival rate for high-risk neuroblastoma is less than 50%, despite multimodal treatment.
Wanrong Li, Xin Li, Yuren Xia, Jian Wang
doaj   +1 more source

Integrating Bulk-seq and Single-cell-seq Reveals Estrogen and MAPK Pathways Associating with Neuroblastoma Outcome

Cancer Control, 2023
Introduction Neuroblastoma is the most common extracranial solid tumor in children. Patients with high-risk neuroblastoma have a 5-year survival rate less than 50% after extensive treatment. Signaling pathways control cell fate decisions that dictate the
Xin Li, Yanlong Zheng, Qiao Ge, Zhenbo Dai, Dejun Zhou, Xiangdong Tian   +5 more
doaj   +1 more source

Exploring the Role of Fibroblasts in Promoting Neuroblastoma Cell Migration and Invasion

Journal of Nanotheranostics
Neuroblastoma, the most common pediatric extracranial solid tumor, arises from the malignant transformation of neural crest progenitors in the peripheral nervous system.
Diana Corallo, Cristina Nardelli, Marcella Pantile, Sara Menegazzo, Alessandra Biffi, Sanja Aveic   +5 more
doaj   +1 more source

Genetic variation associated with childhood and adult stature and risk of MYCN‐amplified neuroblastoma

Cancer Medicine, 2020
Background Neuroblastoma is the most common pediatric solid tumor. MYCN‐amplification is an important negative prognostic indicator and inherited genetic contributions to risk are incompletely understood.
Eleanor C. Semmes, Erica Shen, Jennifer L. Cohen, Chenan Zhang, Qingyi Wei, Jillian H. Hurst, Kyle M. Walsh   +6 more
doaj   +1 more source

The implementation of a national paediatric oncology protocol for neuroblastoma in South Africa

, 2021
: Purpose The aim of the World Health Organization-International Paediatric Oncology Society is to improve childhood cancer survival in low- and middle-income countries to 60% by 2030.
Poole, Janet, Buchner, Ane, Hadley, G.P., Moonsamy, Nicolene, van Zyl, Anel, Van Heerden, Jaques, Hendricks, Marc, Harrison, Derek, du Plessis, Jan, Johani, Johani, Uys, Ronelle, van Emmenes, Barry, Rowe, Biance, Kruger, Mariana, Naidu, Gita, Bassingthwaighte, Mairi, Jan du Plessis, Johani Johani, Ronelle Uys, Biance Rowe, Derek Harrison, Janet Poole, Nicolene Moonsamy, Gita Naidu, Jaques van Heerden, Mairi Bassingthwaighte, Anel van Zyl, Ané Büchner, Barry van Emmenes, Mariana Kruger, G. P. Hadley, Marc Hendricks, null null   +32 more
core   +1 more source

Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells

Cell Reports, 2016
High-risk neuroblastoma remains one of the deadliest childhood cancers. Identification of metabolic pathways that drive or maintain high-risk neuroblastoma may open new avenues of therapeutic interventions.
Mengling Liu, Yingfeng Xia, Jane Ding, Bingwei Ye, Erhu Zhao, Jeong-Hyeon Choi, Ahmet Alptekin, Chunhong Yan, Zheng Dong, Shuang Huang, Liqun Yang, Hongjuan Cui, Yunhong Zha, Han-Fei Ding   +13 more
doaj   +1 more source

Patient-derived models: Advanced tools for precision medicine in neuroblastoma

Frontiers in Oncology, 2023
Neuroblastoma is a childhood cancer derived from the sympathetic nervous system. High-risk neuroblastoma patients have a poor overall survival and account for ~15% of childhood cancer deaths.
Kristina Aaltonen, Katarzyna Radke, Aleksandra Adamska, Alexandra Seger, Adriana Mañas, Daniel Bexell   +5 more
doaj   +1 more source

Neuroblastoma: Triptolide Therapy

, 2011
Neuroblastoma is the most common pediatric extracranial tumor, and advanced-stage cases are highly resistant to conventional chemotherapy. Heat-shock protein-70 (Hsp-70) is overexpressed in several human malignancies, and its inhibition has been shown to
Antonoff, Mara B, Saluja, Ashok K, Mara B. Antonoff, Ashok K. Saluja   +3 more
core   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source