Results 31 to 40 of about 131,868 (167)

Engineering neuroblastoma models for clinical translation

Engineered Regeneration
Neuroblastoma is a profoundly heterogenous extracranial solid tumor in pediatric patients. Elevated risk grade of neuroblastoma has been correlated with unsatisfactory prognosis and resistance to chemotherapy.
Taiyu Song, Rui Liu, Feika Bian, Bin Kong, Jingjing Gan   +4 more
doaj   +1 more source

Bioinformatics analysis of miRNAs in the neuroblastoma 11q-deleted region reveals a role of miR-548l in both 11q-deleted and MYCN amplified tumour cells

Scientific Reports, 2022
Neuroblastoma is a childhood tumour that is responsible for approximately 15% of all childhood cancer deaths. Neuroblastoma tumours with amplification of the oncogene MYCN are aggressive, however, another aggressive subgroup without MYCN amplification ...
Sanja Jurcevic, Simon Keane, Emmy Borgmästars, Zelmina Lubovac-Pilav, Katarina Ejeskär   +4 more
doaj   +1 more source

Sunitinib suppress neuroblastoma growth through degradation of MYCN and inhibition of angiogenesis.

PLoS ONE, 2014
Neuroblastoma, a tumor of the peripheral sympathetic nervous system, is the most common and deadly extracranial tumor of childhood. The majority of high-risk neuroblastoma exhibit amplification of the MYCN proto-oncogene and increased neoangiogenesis ...
Raul Calero, Esther Morchon, John Inge Johnsen, Rosario Serrano   +3 more
doaj   +1 more source

XPO1/CRM1 is a promising prognostic indicator for neuroblastoma and represented a therapeutic target by selective inhibitor verdinexor

Journal of Experimental & Clinical Cancer Research, 2021
Background High-risk neuroblastoma patients have a 5-year survival rate of less than 50%. It’s an urgent need to identify new therapeutic targets and the appropriate drugs.
Lijia Pan, Cheng Cheng, Peiwen Duan, Kai Chen, Yeming Wu, Zhixiang Wu   +5 more
doaj   +1 more source

Hopes on immunotherapy targeting B7-H3 in neuroblastoma

Translational Oncology, 2023
Neuroblastoma is one of the most aggressive cancer forms in children, with highly heterogenous clinical manifestations ranging from spontaneous regression to high metastatic capacity.
Rafael Pulido, Caroline E. Nunes-Xavier
doaj   +1 more source

Akt2 regulates metastatic potential in neuroblastoma. [PDF]

PLoS ONE, 2013
Activation of PI3K/AKT pathway correlates with poor prognosis in patients with neuroblastoma. Our previous studies have demonstrated that PI3K/AKT signaling is critical for the oncogenic transformations induced by gastrin-releasing peptide (GRP) and its ...
Jingbo Qiao, Sora Lee, Pritha Paul, Lan Qiao, Chase J Taylor, Cameron Schlegel, Nadja C Colon, Dai H Chung   +7 more
doaj   +1 more source

Expression patterns of bone morphogenetic protein 7 (BMP7) and its prognostic roles in neuroblastoma: An integrated bioinformatics analysis.

PLoS ONE
BackgroundBone morphogenetic proteins (BMPs) are associated with the prognosis of various types of adult cancers. However, the expressions and prognosis of BMPs in pediatric neuroblastoma remain unclear.MethodsSix publicly available neuroblastoma cohorts
Haiwei Wang, Xinrui Wang, Liangpu Xu
doaj   +1 more source

DNA repair and cholesterol-mediated drug efflux induce dose-dependent chemoresistance in nutrient-deprived neuroblastoma cells

iScience, 2021
Summary: Neuroblastoma is a solid, heterogeneous pediatric tumor. Chemotherapy is widely used to treat neuroblastoma. However, dose-dependent responses and chemoresistance mechanisms of neuroblastoma cells to anticancer drugs remain challenging. Here, we
Soo Yeon Chae, Dowoon Nam, Do Young Hyeon, Areum Hong, Timothy Dain Lee, Sujin Kim, Dongjoon Im, Jiwon Hong, Chaewon Kang, Ji Won Lee, Daehee Hwang, Sang-Won Lee, Hugh I. Kim   +12 more
doaj   +1 more source

Cervical neuroblastoma [PDF]

Indian Journal of Otolaryngology and Head & Neck Surgery, 2007
Cervical neuroblastoma is relatively uncommon. It present, most often as a firm mass in the lateral neck. Primary neuroblastomas of the neck usually arise in the cervical sympathetic ganglia. They are the sixth most common head and neck extracranial neoplasms. Neuroblastoma is the most common malignancy in children under 1 year of age.
Harjitpal, Singh, C, Mohan, N K, Mohindroo, D R, Sharma   +3 more
openaire   +2 more sources

Neuroblastoma

Saudi Medical Journal, 2001
Due to the poor results achieved on combination chemotherapy and the unproven cost-effectiveness value of myeloablative therapy, the question has been raised; should patients with stage IV neuroblastoma be actively treated? The aim of the current study is to analyze retrospectively treatment results of 43 children with neuroblastoma with special stress
H M, Meir, I, Balawi, H, Nayel, M K, Yousef, S, Badawood, M, Al-Mobarak   +5 more
openaire   +2 more sources