Results 11 to 20 of about 185,865 (259)

AKT inhibitor Hu7691 induces differentiation of neuroblastoma cells

Acta Pharmaceutica Sinica B, 2023
While neuroblastoma accounts for 15% of childhood tumor-related deaths, treatments against neuroblastoma remain scarce and mainly consist of cytotoxic chemotherapeutic drugs.
Shaowei Bing, Senfeng Xiang, Zhimei Xia, Yilong Wang, Zhonghai Guan, Jinxin Che, Aixiao Xu, Xiaowu Dong, Ji Cao, Bo Yang, Jinhu Wang, Qiaojun He, Meidan Ying   +12 more
doaj   +1 more source

The association of clinical characteristics and tumour markers With image-defined risk factors in the management of neuroblastoma in South Africa [PDF]

, 2022
: Aims: Image-defined risk factors (IDRFs) in neuroblastoma predict surgical complications and management outcomes. As there is a lack of data regarding the association of IDRFs with clinical and pathological factors, this study evaluated the prognostic ...
Naidu, G., Poole, Janet, Buchner, Ane, Van Zyl, Anel, Van Heerden, Jaques, Kruger, M., Esterhuizen, Tonya Marianne, Hendricks, Marc, Poole, J., du Plessis, J., Esterhuizen, T.M., van Zyl, A., Kruger, Mariana, Hendricks, M., Du Plessis, Jan, Naidu, Gita, Mathews, Elmarie, Van Emmenes, Barry, Buchner, A., van Emmenes, B., Mathews, E., Van Heerden, J., J. Poole, J. du Plessis, A. van Zyl, G. Naidu, J. van Heerden, M. Kruger, A. Büchner, E. Mathews, T.M. Esterhuizen, M. Hendricks, B. van Emmenes   +32 more
core   +1 more source

CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis

Journal of Experimental & Clinical Cancer Research, 2023
Background The repressor element-1 silencing transcription factor (REST), a master transcriptional repressor, is essential for maintenance, self-renewal, and differentiation in neuroblastoma.
Janardhan Keshav Karapurkar, Min-Seong Kim, Jencia Carminha Colaco, Bharathi Suresh, Neha Sarodaya, Dong-Ho Kim, Chang-Hwan Park, Seok-Ho Hong, Kye-Seong Kim, Suresh Ramakrishna   +9 more
doaj   +1 more source

Autophagy inhibition improves the cytotoxic effects of receptor tyrosine kinase inhibitors

Cancer Cell International, 2018
Background A growing field of evidence suggests the involvement of oncogenic receptor tyrosine kinases (RTKs) in cell transformation. Deregulated activity of RTKs in tumors can determine disease progression and therapeutic responses in several types of ...
Sanja Aveic, Marcella Pantile, Pierfrancesco Polo, Viktoryia Sidarovich, Marilena De Mariano, Alessandro Quattrone, Luca Longo, Gian Paolo Tonini   +7 more
doaj   +1 more source

Prognostic analysis of E2F transcription factors E2F1 and E2F3 in four independent pediatric neuroblastoma cohorts

BMC Pediatrics, 2022
Background Previously, we had analyzed the prognosis of E2F transcription factors across adult tumor types. However, the expressions and prognosis of E2F transcription factors in pediatric neuroblastoma have not yet been fully studied.
Haiwei Wang, Xinrui Wang, Liangpu Xu, Ji Zhang   +3 more
doaj   +1 more source

Inhibition of Poly(ADP-Ribose) polymerase enhances the toxicity of 131I-Metaiodobenzylguanidine/Topotecan combination therapy to cells and xenografts that express the noradrenaline transporter [PDF]

, 2012
Targeted radiotherapy using [131I]meta-iodobenzylguanidine ([131I]MIBG) has produced remissions in some neuroblastoma patients. We previously reported that combining [131I]MIBG with the topoisomerase I (Topo-I) inhibitor topotecan induced long-term DNA ...
McCluskey, Anthony G, Babich, John W, Champion, Sue, Mairs, Robert J, Boyd, Marie, Gaze, Mark N, Tesson, Mathias, Pimlott, Sally L   +7 more
core   +3 more sources

Engineered Peptide Self-Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors. [PDF]

Adv Sci (Weinh)
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
He Y, Lu X, Yang CQ, Zhang R, Wan B, Ni X, Mei D.   +6 more
europepmc   +2 more sources

Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells [PDF]

, 2009
BACKGROUND: Chemoresistance acquisition may influence cancer cell biology. Here, bioinformatics analysis of gene expression data was used to identify chemoresistance-associated changes in neuroblastoma biology.
Tatyana Suhan, Barth, Susanne, Doerr, Hans Wilhelm, Breitling Rainer, Hans W Doerr, Suhan, Tatyana, Doerr Hans W, Cinatl Jindrich, Cinatl jr., Jindrich, Hinsch, Nora, Doerr, Hans W., Denise Klassert, Cinatl Jaroslav, Bernd Mayer, Nora Hinsch, Barth Susanne, Hinsch Nora, Klassert Denise, Cinatl, Jaroslav, Susanne Barth, Hinsch, N., Doerr, H., Mayer, B., Martin Michaelis, Breitling, Rainer, Breitling, R., Mayer Bernd, Cinatl, J., Klassert, Denise, Jindrich Cinatl, Suhan Tatyana, Michaelis, Martin, Cinatl, Jindrich, Rainer Breitling, Barth, S., Suhan, T., Michaelis, M., Mayer, Bernd, Klassert, D., Jaroslav Cinatl, Michaelis Martin, Breitling, Rainer; id_orcid   +41 more
core   +1 more source

Patient-derived organoids (PDOs) as a novel in vitro model for neuroblastoma tumours

BMC Cancer, 2019
Background Neuroblastoma (NB) is a paediatric tumour of the sympathetic nervous system. Half of all cases are defined high-risk with an overall survival less than 40% at 5 years from diagnosis.
P. Fusco, B. Parisatto, E. Rampazzo, L. Persano, C. Frasson, A. Di Meglio, A. Leslz, L. Santoro, B. Cafferata, A. Zin, E. Cimetta, G. Basso, M. R. Esposito, G. P. Tonini   +13 more
doaj   +1 more source

Polyphenon E enhances the antitumor immune response in neuroblastoma by inactivating myeloid suppressor cells [PDF]

, 2013
This is the author's accepted manuscript. The final published article is available from the link below. Note: In this manuscript as well as in the original published version of this article the word "Polyphenon" was incorrectly spelled in the title as ...
Chayka, O, Sala, A, Piotrowska, I, Himoudi, N, D'Alicarnasso, M, Cantilena, S, Santilli, G, Morgenstern, DA, Thrasher, AJ, Pearson, K, Anderson, J   +10 more
core   +1 more source