Results 11 to 20 of about 137,730 (260)

Novel Therapies for Relapsed and Refractory Neuroblastoma

Children, 2018
While recent increases in our understanding of the biology of neuroblastoma have allowed for more precise risk stratification and improved outcomes for many patients, children with high-risk neuroblastoma continue to suffer from frequent disease relapse,
Peter Zage
exaly   +3 more sources

Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells

Cell Reports, 2016
High-risk neuroblastoma remains one of the deadliest childhood cancers. Identification of metabolic pathways that drive or maintain high-risk neuroblastoma may open new avenues of therapeutic interventions.
Erhu Zhao, Han-Fei Ding, Hongjuan Cui
exaly   +3 more sources

Neuroblastoma [PDF]

Pediatric Blood & Cancer, 2021
AbstractThe survival of patients with high‐risk neuroblastoma has improved significantly with the use of intensive multimodality treatment regimens, including chemotherapy, surgery, radiation therapy, myeloablative chemotherapy followed by stem cell rescue, and immunotherapy.
Christine Chung, Tom Boterberg, John Lucas, Joseph Panoff, Dominique Valteau‐Couanet, Barbara Hero, Rochelle Bagatell, Christine E. Hill‐Kayser   +7 more
openaire   +2 more sources

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31-Mediated Degradation of CBX8. [PDF]

Adv Sci (Weinh)
This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Zeng H, Ye Z, Zheng M, Pan J, Tan T, Yang J, Li J, Zhao Z, Long T, Zhang L, Sethi G, Yang T, Hu C, Zou Y.   +13 more
europepmc   +2 more sources

Why Is Aneuploidy Associated with Favorable Outcome in Neuroblastoma?

Biomolecules, 2021
Neuroblastoma is a pediatric cancer, onset with localized as well as metastatic disease. Localized tumors usually show a high content of aneuploid cells.
Gian Paolo Tonini
doaj   +1 more source

Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma

Life Science Alliance, 2021
Video and gene expression analyses coupled with the RNAi technique reveal microtubule-dependent, neuronal-like nucleokinetic migration in a noradrenergic type of neuroblastoma, providing a glimpse into the mechanism by which noradrenergic neuroblastoma ...
Elena A Afanasyeva, Moritz Gartlgruber, Tatsiana Ryl, Bieke Decaesteker, Geertrui Denecker, Gregor Mönke, Umut H Toprak, Andres Florez, Alica Torkov, Daniel Dreidax, Carl Herrmann, Konstantin Okonechnikov, Sara Ek, Ashwini Kumar Sharma, Vitaliya Sagulenko, Frank Speleman, Kai-Oliver Henrich, Frank Westermann   +17 more
doaj   +1 more source

Autophagic flux inhibition enhances cytotoxicity of the receptor tyrosine kinase inhibitor ponatinib

Journal of Experimental & Clinical Cancer Research, 2020
Background Despite reported advances, acquired resistance to tyrosine kinase inhibitors still represents a serious problem in successful cancer treatment.
Diana Corallo, Fabio Pastorino, Marcella Pantile, Elena Mariotto, Federico Caicci, Giampietro Viola, Mirco Ponzoni, Gian Paolo Tonini, Sanja Aveic   +8 more
doaj   +1 more source

TP53 and TP53-associated genes are correlated with the prognosis of paediatric neuroblastoma

BMC Genomic Data, 2022
Background TP53 is rarely mutated in paediatric neuroblastoma. The prognosis of TP53 and TP53-associated genes in paediatric neuroblastoma is unclear.
Haiwei Wang, Xinrui Wang, Liangpu Xu, Ji Zhang   +3 more
doaj   +1 more source

Inhibition of PI3 kinase isoform p110α suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase

Cell & Bioscience, 2022
Background In neuroblastoma, hyperactivation of the PI3K signaling pathway has been correlated with aggressive neuroblastomas, suggesting PI3Ks as promising targets for the treatment of neuroblastoma.
Yue Guo, Donghao Guo, Shaoting Zhang, Yuan Zhang, Xiaoyan He, Xiaohua Jiang, Andrew Man-Lok Chan, Lin Zou, Jianmin Sun, Hui Zhao   +9 more
doaj   +1 more source

Chromosome 1p36 candidate gene ZNF436 predicts the prognosis of neuroblastoma: a bioinformatic analysis

Italian Journal of Pediatrics, 2023
Background Genetic 1p deletion is reported in 30% of all neuroblastoma and is associated with the unfavorable prognosis of neuroblastoma. The expressions and prognosis of 1p candidate genes in neuroblastoma are unclear.
Haiwei Wang, Xinrui Wang, Liangpu Xu
doaj   +1 more source