Results 71 to 80 of about 345,011 (339)

Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low‐Grade Gliomas With BRAF V600E Mutation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan, Damien Faury, Alexander G. Weil, Harrison J. Westwick, Nada Jabado, Sébastien Perreault   +5 more
wiley   +1 more source

Bioinformatics analysis of miRNAs in the neuroblastoma 11q-deleted region reveals a role of miR-548l in both 11q-deleted and MYCN amplified tumour cells

Scientific Reports, 2022
Neuroblastoma is a childhood tumour that is responsible for approximately 15% of all childhood cancer deaths. Neuroblastoma tumours with amplification of the oncogene MYCN are aggressive, however, another aggressive subgroup without MYCN amplification ...
Sanja Jurcevic, Simon Keane, Emmy Borgmästars, Zelmina Lubovac-Pilav, Katarina Ejeskär   +4 more
doaj   +1 more source

Cellular and gene signatures of tumor-infiltrating dendritic cells and natural-killer cells predict prognosis of neuroblastoma

Nature Communications, 2020
Tumor-infiltrating lymphocytes play an essential role in improving clinical outcome of neuroblastoma (NB) patients, but their relationship with other tumor-infiltrating immune cells in the T cell-inflamed tumors remains poorly investigated.
O. Melaiu, M. Chierici, V. Lucarini, Giuseppe Jurman, L. Conti, R. de Vito, R. Boldrini, L. Cifaldi, A. Castellano, Cesare Furlanello, V. Barnaba, F. Locatelli, D. Fruci   +12 more
semanticscholar   +1 more source

Parent‐to‐Child Information Disclosure in Pediatric Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite professional consensus regarding the importance of open communication with pediatric cancer patients about their disease, actual practice patterns of disclosure are understudied. Extant literature suggests a significant proportion of children are not told about their diagnosis/prognosis, which is purported to negatively ...
Rachel A. Kentor, Flora Hoodin, Michelle Byrd, Kristin A. Kullgren, Leah LaLonde, Lauren Benkoske, Patrick Smith, Dawn Carson, Karen MacDonald, Susumu Inoue, Brenda Kitchen, Kate Gowans, Gregory A. Yanik   +12 more
wiley   +1 more source

Engineering neuroblastoma models for clinical translation

Engineered Regeneration
Neuroblastoma is a profoundly heterogenous extracranial solid tumor in pediatric patients. Elevated risk grade of neuroblastoma has been correlated with unsatisfactory prognosis and resistance to chemotherapy.
Taiyu Song, Rui Liu, Feika Bian, Bin Kong, Jingjing Gan   +4 more
doaj   +1 more source

XPO1/CRM1 is a promising prognostic indicator for neuroblastoma and represented a therapeutic target by selective inhibitor verdinexor

Journal of Experimental & Clinical Cancer Research, 2021
Background High-risk neuroblastoma patients have a 5-year survival rate of less than 50%. It’s an urgent need to identify new therapeutic targets and the appropriate drugs.
Lijia Pan, Cheng Cheng, Peiwen Duan, Kai Chen, Yeming Wu, Zhixiang Wu   +5 more
doaj   +1 more source

Hopes on immunotherapy targeting B7-H3 in neuroblastoma

Translational Oncology, 2023
Neuroblastoma is one of the most aggressive cancer forms in children, with highly heterogenous clinical manifestations ranging from spontaneous regression to high metastatic capacity.
Rafael Pulido, Caroline E. Nunes-Xavier
doaj   +1 more source

Improper Supplementation Habits of Folic Acid Intake by Hungarian Pregnant Women: Improper Recommendations [PDF]

, 2008
Background: Neural tube defects (NTDs) are some of the most common congenital anomalies. Proper folic acid supplementation is a dominant risk factor, which has been shown to decrease the incidence of NTDs.
Bognár, M., Constantin, Tamás, Garami, Miklós, Hauser, Péter, Jakab, Zsuzsanna, Müller, Judit, Ponyi, Andrea, Schuler, Dezső   +7 more
core   +1 more source

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

Sunitinib suppress neuroblastoma growth through degradation of MYCN and inhibition of angiogenesis.

PLoS ONE, 2014
Neuroblastoma, a tumor of the peripheral sympathetic nervous system, is the most common and deadly extracranial tumor of childhood. The majority of high-risk neuroblastoma exhibit amplification of the MYCN proto-oncogene and increased neoangiogenesis ...
Raul Calero, Esther Morchon, John Inge Johnsen, Rosario Serrano   +3 more
doaj   +1 more source