Results 81 to 90 of about 268,028 (214)
Instance Segmentation of Dense and Overlapping Objects via Layering [PDF]
arXiv, 2022 Instance segmentation aims to delineate each individual object of interest in an image. State-of-the-art approaches achieve this goal by either partitioning semantic segmentations or refining coarse representations of detected objects. In this work, we propose a novel approach to solve the problem via object layering, i.e. by distributing crowded, even
arxiv
Selective inhibition of the p53–MDM2 interaction by nutlin drugs: a new therapeutic perspective for neuroblastoma [PDF]
, 2013 Neuroblastoma is one of the most common and most deadly childhood tumors. There is an unmet need to develop new therapeutic modalities for this malignancy that preferentially should be guided by our increasing knowledge of the biology of neuroblastoma ...
De Paepe, Anne +5 more
core +1 more source
DNA methylation profiling of primary neuroblastoma tumors using methyl-CpG-binding domain sequencing [PDF]
, 2016 Comprehensive genome-wide DNA methylation studies in neuroblastoma (NB), a childhood tumor that originates from precursor cells of the sympathetic nervous system, are scarce. Recently, we profiled the DNA methylome of 102 well-annotated primary NB tumors
Decock, Anneleen +4 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2021 Although a rare disease, neuroblastoma accounts for the highest proportion of childhood cancer deaths. There is a lack of recurrent somatic mutations in neuroblastoma embryonal tumours, suggesting a possible role for epigenetic alterations in driving ...
Aleksandar Krstic +12 more
doaj +1 more source
TrajPy: empowering feature engineering for trajectory analysis across domains [PDF]
arXiv, 2023 Trajectories, sequentially measured quantities that form a path, are an important presence in many different fields, from hadronic beams in physics to electrocardiograms in medicine. Trajectory anal-ysis requires the quantification and classification of curves either using statistical descriptors or physics-based features.
arxiv
The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo. [PDF]
, 2019 Neuroblastoma is the most common extracranial solid tumor of childhood and accounts for 15% of all pediatric cancer-related deaths. New therapies are needed to improve outcomes for children with high-risk and relapsed tumors. Inhibitors of the RET kinase
Flynn, Sean M +7 more
core
Improper Supplementation Habits of Folic Acid Intake by Hungarian Pregnant Women: Improper Recommendations [PDF]
, 2008 Background: Neural tube defects (NTDs) are some of the most common congenital anomalies. Proper folic acid supplementation is a dominant risk factor, which has been shown to decrease the incidence of NTDs.
Bognár, M. +7 more
core +1 more source
Advances in Risk Classification and Treatment Strategies for Neuroblastoma.
Journal of Clinical Oncology, 2015 Risk-based treatment approaches for neuroblastoma have been ongoing for decades. However, the criteria used to define risk in various institutional and cooperative groups were disparate, limiting the ability to compare clinical trial results. To mitigate
N. Pinto +12 more
semanticscholar +1 more source
Tumor to normal single cell mRNA comparisons reveal a pan-neuroblastoma cancer cell
bioRxiv, 2020 Neuroblastoma is a childhood cancer that resembles developmental stages of the neural crest. It is not established what developmental processes neuroblastoma cancer cells represent. Here, we sought to reveal the phenotype of neuroblastoma cancer cells by
Gerda Kildisiute +38 more
semanticscholar +1 more source
Genetic Predisposition to Neuroblastoma
Children, 2018 Neuroblastoma is the most common solid tumor in children under the age of one. It displays remarkable phenotypic heterogeneity, resulting in differences in outcomes that correlate with clinical and biologic features at diagnosis.
Erin K. Barr, Mark A. Applebaum
doaj +1 more source