Results 51 to 60 of about 358,809 (243)

Somatosensory tinnitus: current evidence and future perspectives [PDF]

, 2017
In some individuals, tinnitus can be modulated by specific maneuvers of the temporomandibular joint, head and neck, eyes, and limbs. Neuroplasticity seems to play a central role in this capacity for modulation, suggesting that abnormal interactions ...
ALTISSIMI, Giancarlo, CIANFRONE, Giancarlo, DE VINCENTIIS, Marco, GRECO, Antonio, RALLI, MASSIMO, TURCHETTA, Rosaria   +5 more
core   +1 more source

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source

Magnitude of Neurocognitive Impairment and Severity of Depression in Geriatric Population

BioMedica, 2021
Background and Objective:  With the increasing life expectancy of the populations and rising prevalence of depressive and neurocognitive disorders, there is a need to address the association between the two in terms of magnitude of the ...
Sadia Yasir, Saad Bin Yasir, Nariman Haider, Sundas Fatima, Mahpara Mazhar, Saima Chaudhry, Asad Tamizuddin Nizami   +6 more
doaj   +1 more source

Disrupted working memory circuitry and psychotic symptoms in 22q11.2 deletion syndrome. [PDF]

, 2014
22q11.2 deletion syndrome (22q11DS) is a recurrent genetic mutation that is highly penetrant for psychosis. Behavioral research suggests that 22q11DS patients exhibit a characteristic neurocognitive phenotype that includes differential impairment in ...
Bearden, CE, Chow, C, Hilton, AE, Ibrahim, A, Jonas, RK, Karlsgodt, KH, Montojo, CA, Vesagas, TK   +7 more
core   +2 more sources

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Examining the association of life course neurocognitive ability with real-world functioning in schizophrenia-spectrum disorders

Schizophrenia Research: Cognition, 2022
There is considerable variability in neurocognitive functioning within schizophrenia-spectrum disorders, and neurocognitive performance ranges from severe global impairment to normative performance.
Sylvia Romanowska, Michael W. Best, Christopher R. Bowie, Colin A. Depp, Thomas L. Patterson, David L. Penn, Amy E. Pinkham, Philip D. Harvey   +7 more
doaj   +1 more source

Environmental and genetic influences on neurocognitive development: the importance of multiple methodologies and time-dependent intervention [PDF]

, 2014
Genetic mutations and environmental factors dynamically influence gene expression and developmental trajectories at the neural, cognitive, and behavioral levels.
Bryson S. E., Clahsen H., D’Souza D., Gopnik M., Guiraud J. A., Karmiloff-Smith A., Pinker S., Wexler K.   +7 more
core   +2 more sources

Advancing Precision Nutrition Through Multimodal Data and Artificial Intelligence

Advanced Science, EarlyView.
Individual responses to food vary dramatically, challenging traditional dietary advice. This review explores how the unique genetic makeup, gut microbiome, and brain activity shape host metabolic health. We examine how artificial intelligence integrates these multimodal data to predict individualized dietary needs, moving beyond one‐size‐fits‐all ...
Yuanqing Fu, Ke Zhang, Zelei Miao, Gaoyi Yang, Yujing Huang, Ju‐Sheng Zheng   +5 more
wiley   +1 more source

Cognitive alterations in patients with non-affective psychotic disorder and their unaffected siblings and parents [PDF]

, 2012
Meijer J, Simons CJP, Quee PJ, Verweij K, GROUP Investigators. Cognitive alterations in patients with non-affective psychotic disorder and their unaffected siblings and ...
Addington, Andreasen, Anselmetti, Appels, Bediou, Benton, Bilder, Blyler, Bora, Brand, Broome, Ceaser, Cornblatt, Dickinson, Egan, Egeland, Genetic Risk and Outcome in Psychosis (GROUP) Investigators, Glass, Green, Greenwood, Gur, Heinrichs, Heinrichs, Jabben, Keefe, Keefe, Keefe, Kelemen, Keshavan, Kremen, Kremen, Kéri, Meiran, Miller, Morice, Nolan, Nuechterlein, Palmer, Palmer, Pukrop, Savla, Sergi, Sitskoorn, Snitz, Sprong, Thornton, Van Hooren, Van Os, Van‘T Wout, Vauth, Versmissen, Wechsler, Welham, Yücel   +53 more
core   +2 more sources

Effect Differences of Omega‐3 Fatty Acids From Plant Oil and Fish Oil on Human Health

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Omega‐3 fatty acids in plant oil is no less than fish oil on human health. ALA in plant oil takes directly healthy effects without conversion to DHA and EPA. Plant oil can be substitutes for fish oil to support partial ω‐3 fatty acids. For people who cannot afford fish oil, plant oil is also good for public health.
Mengxue Fang, Chunyan Xiang, Liangxiao Zhang, Peiwu Li   +3 more
wiley   +1 more source