Results 161 to 170 of about 319,447 (239)

Underestimated virus impaired cognition-more evidence and more work to do. [PDF]

Front Immunol
Awan MUN, Mahmood F, Peng XB, Zheng F, Xu J.   +4 more
europepmc   +1 more source

NFE2L1 as a central regulator of proteostasis in neurodegenerative diseases: interplay with autophagy, ferroptosis, and the proteasome. [PDF]

Front Mol Neurosci
Khodadadi H, Łuczyńska K, Winiarczyk D, Leszczyński P, Taniguchi H.   +4 more
europepmc   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity. [PDF]

Alzheimers Dement
Gogniat MA, Khan OA, Li J, Park C, Hudson Robb W, Zhang P, Sun Y, Moore EE, Houston ML, Pechman KR, Shashikumar N, Taylor Davis L, Liu D, Landman BA, Cole KR, Bolton CJ, Gifford KA, Hohman TJ, Full K, Jefferson AL.   +19 more
europepmc   +1 more source

Calpastatin, a calpain specific inhibitor, reduce seizures in a mouse model of temporal lobe epilepsy

Epilepsia Open, EarlyView.
Abstract Epilepsy is a chronic condition characterized by unpredictable and recurrent spontaneous seizures. In a previous study, we reported that pharmacological inhibition of calpain prevented epileptogenesis in the rat pilocarpine model. In this study, we demonstrate that transgenic overexpression of calpastatin, the endogenous inhibitor of calpain ...
Philip M. Lam, Mala V. Rao, Ralph A. Nixon, Marco I. González   +3 more
wiley   +1 more source

Comparative Brain and Serum Exosome Expression of Biomarkers in an Experimental Model of Alzheimer-Type Neurodegeneration: Potential Relevance to Liquid Biopsy Diagnostics. [PDF]

Int J Mol Sci
de la Monte SM, Yang Y, Prabhu A, Tong M.   +3 more
europepmc   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infection. [PDF]

NPJ Parkinsons Dis
Chatterjee D, Kurup D, Smeyne RJ.
europepmc   +1 more source

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders

Exploration, EarlyView.
Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen   +4 more
wiley   +1 more source