Results 161 to 170 of about 395,485 (325)

Assessing the Relative Importance of Imaging and Serum Biomarkers in Capturing Disability, Cognitive Impairment, and Clinical Progression in Multiple Sclerosis

Advanced Science, EarlyView.
Using machine‐learning analyses in two independent multiple sclerosis cohorts, spinal cord atrophy and cortical degeneration emerged as key predictors of disability and progression independent of relapses. Deep gray matter damage further improved prediction, while serum biomarkers of brain damage provided complementary information, highlighting the ...
Alessandro Cagol, Pascal Benkert, Sabine Schaedelin, Mario Ocampo‐Pineda, Noemi Montobbio, Po‐Jui Lu, Batuhan Ayci, Antonia Wenger, Alfi Aran Shukur, Kornelius Kaim, Lester Melie‐Garcia, Matthias Weigel, Alessio Signori, Pasquale Calabrese, Ludwig Kappos, Maria Pia Sormani, Jens Kuhle, Cristina Granziera   +17 more
wiley   +1 more source

Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD [PDF]

, 2014
Michael E. Ward, Alice Taubes, Robert Y. Chen, Bruce L. Miller, Chantelle F. Sephton, Jeffrey M. Gelfand, Sakura Minami, John Boscardin, Lauren Herl Martens, William W. Seeley, Gang Yu, Joachim Herz, Anthony J. Filiano, Andrew E. Arrant, Erik D. Roberson, Timothy W. Kraft, Robert V. Farese, Ari Green, Li Gan   +18 more
openalex   +1 more source

Relationships between diabetes-related vascular risk factors and neurodegeneration biomarkers in healthy aging and Alzheimer's disease

, 2022
Cassandre Palix, Francesca Felisatti, Julie Gonneaud, Elizabeth Kuhn, Florence Mézenge, Brigitte Landeau, Anne Chocat, Anne Quillard, Stéphanie Egret, Marion Delarue, Vincent de La Sayette, Denis Vivien, Gaël Chételat, Géraldine Poisnel   +13 more
openalex   +1 more source

A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration [PDF]

, 2022
Dawei Meng, Qian Zheng, Xue Zhang, Li Luo, Yichang Jia   +4 more
openalex   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cell states

Nature Communications
Glioblastoma (GBM) is the most common primary brain cancer. It causes death mainly by local invasion via several routes, including infiltration of white matter tracts and penetration of perivascular spaces.
Milena Doroszko, Rebecka Stockgard, Irem Uppman, Josephine Heinold, Faidra Voukelatou, Hitesh Bhagavanbhai Mangukiya, Thomas O. Millner, Madeleine Skeppås, Mar Ballester Bravo, Ramy Elgendy, Maria Berglund, Ludmila Elfineh, Cecilia Krona, Soumi Kundu, Katarzyna Koltowska, Silvia Marino, Ida Larsson, Sven Nelander   +17 more
doaj   +1 more source

Brainstem neurodegeneration correlates with clinical dysfunction in SCA1 but not in SCA2. A quantitative volumetric, diffusion and proton spectroscopy MR study [PDF]

, 2004
Laura Guerrini
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Paraquat and MPTP induce neurodegeneration and alteration in the expression profile of microRNAs: the role of transcription factor Nrf2 [PDF]

, 2017
Qingqing Wang, Nan Ren, Zhipeng Cai, Qingxia Lin, Zhangjing Wang, Qunwei Zhang, Siying Wu, Huangyuan Li   +7 more
openalex   +1 more source

(Pre)Diabetes, Greater Glycemia, and Greater Daily Glucose Variability are Associated with Lower Retinal Nerve Fiber Layer Thickness, an Index of Neurodegeneration and Precursor of Diabetic Retinopathy– The Maastricht Study [PDF]

, 2021
Frank C. T. van der Heide, Yuri D. Foreman, Iris Franken, Ronald M.A. Henry, Abraham A. Kroon, Pieter C. Dagnelie, Simone J. P. M. Eussen, Tos T. J. M. Berendschot, Jan S.A.G. Schouten, Carroll A.B. Webers, Miranda T. Schram, Carla Kallen, Marleen M. J. van Greevenbroek, Anke Wesselius, Casper G. Schalkwijk, Nicolaas C. Schaper, Martijn C.G.J. Brouwers, Coen D.A. Stehouwer   +17 more
openalex   +1 more source