Results 151 to 160 of about 271,126 (314)

Mitochondrial optic neuropathy: In vivo model of neurodegeneration and neuroprotective strategies

, 2010
Julio C Rojas, Francisco Gonzalez-LimaDepartments of Psychology, Pharmacology and Toxicology, University of Texas at Austin, Austin, TX, USAAbstract: This review summarizes the characteristics of a rodent toxicologic model of optic neuropathy induced by ...
Francisco Gonzalez-Lima, Julio C Rojas
core  

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Removing protein aggregates: the role of proteolysis in neurodegeneration

, 2011
A common characteristic of neurodegenerative diseases like Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD) is the accumulation of protein aggregates.
D. A.T. Nijholt, W. Scheper, Nijholt, D. A. T., de Kimpe, L., Scheper, W., H. L. Elfrink, J. J.M. Hoozemans, Elfrink, H.L., Nijholt, D.A.T., L. De Kimpe, Hoozemans, J. J. M., Hoozemans, J.J.M., Elfrink, H. L.   +12 more
core   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Zoom in on neurodegeneration

, 2006
Despite the existence of several scientific journals that publish research papers and reviews related to neurodegenerative diseases, a journal specifically devoted to the molecular and cellular aspects of disease mechanisms is lacking.
Huaxi, Xu, Bu, Guojun, Golde, Todd E., Huaxi Xu, Xu Huaxi, Guojun, Bu, Bu Guojun, Guojun Bu, Golde Todd E, Xu, Huaxi, Golde, Todd E, Todd E Golde   +11 more
core   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration

, 2018
Several molecular pathways are currently being targeted in attempts to develop disease-modifying therapies to slow down neurodegeneration in Parkinson’s disease.
Colca, Jerry, Brundin, Patrik, Patrik Brundin, David K. Simon, Emmanuel Quansah, J. William Langston, Quansah, Emmanuel, Peelaerts, Wouter, Jerry Colca, Simon, David, Wouter Peelaerts, Langston, J. William   +11 more
core   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Inhibition of lysosome membrane recycling causes accumulation of gangliosides that contribute to neurodegeneration

, 2018
Lysosome membrane recycling occurs at the end of the autophagic pathway and requires proteins that are mostly encoded by genes mutated in neurodegenerative diseases. However, its implication in neuronal death is still unclear.
Emeline Chu-Van, Catherine Caillaud, Darios, Frédéric, Chu-Van, Emeline, Alexandre Seyer, Frédéric Darios, Julie Pernelle, Alexandra Durr, Lustremant, Céline, Jean-Philippe Puech, Boutry, Maxime, El Hachimi, Khalid Hamid, Matusiak, Raphaël, Caillaud, Catherine, Mochel, Fanny, Maxime Boutry, Julien Branchu, Benoit Colsch, Durr, Alexandra, Stevanin, Giovanni, Pernelle, Julie, Seyer, Alexandre, Pujol, Claire, Colsch, Benoit, Khalid Hamid El Hachimi, Raphaël Matusiak, Fanny Mochel, Giovanni Stevanin, Alexandre Pierga, Brice, Alexis, Kostantin Dobrenis, Céline Lustremant, Puech, Jean-Philippe, Marion Poirel, Poirel, Marion, Claire Pujol, Dobrenis, Kostantin, Branchu, Julien, Alexis Brice, Pierga, Alexandre   +39 more
core   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source