Results 131 to 140 of about 271,126 (314)
A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi +17 more
wiley +1 more source
Experimental and Molecular Medicine, 2019 Diabetes: Inflammation in insulin resistance A potassium-regulating molecule, Kir6.1, blocks inflammation and prevents insulin resistance (IR), a hallmark of type 2 diabetes. Insulin triggers cellular glucose absorption, lowering blood glucose levels. In
Ren-Hong Du +5 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay +13 more
wiley +1 more source
Aging Cell, 2007 SummaryWhen properly controlled, Ca2+ fluxes across the plasma membrane and between intracellular compartments play critical roles in fundamental functions of neurons, including the regulation of neurite outgrowth and synaptogenesis, synaptic transmission and plasticity, and cell survival.
openaire +2 more sources
Is microtubule dynamics imbalance an early event in MPTP-induced neurodegeneration?
, 2009 The molecular pathways implicated in neurodegenerative disorders are gradually being elucidated and several culprits including accumulation of aberrant or misfolded proteins, mitochondrial injury, oxidative and nitrosative stress, and failure of axonal ...
E. Giavini +5 more
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Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier +6 more
wiley +1 more source
P1564: THE ROLE OF THE NECROPTOSIS IN SEVERE MALARIAL ANEMIA: INSIGHTS FROM RIPK1 ABLATION MODELS
HemaSphere, 2023 Ana Pêgo +2 more
doaj +1 more source
Neuronal differentiation and neurodegeneration: the role of Nogo-A?
, 2022 Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. One of the main characteristics of this disorder is the degenerative loss of midbrain dopaminergic (DAergic) neurons of the substantia nigra pars compacta (SNpc ...
Lanci, Luigina
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