Results 171 to 180 of about 366,723 (337)
Apoptosis Has a Prolonged Role in the Neurodegeneration after Hypoxic Ischemia in the Newborn Rat [PDF]
, 2000 Wako Nakajima +7 more
openalex +1 more source
Post‐Translational Modifications in Cilia and Ciliopathies
Advanced Science, EarlyView.This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley +1 more source
Amyloid diseases: Abnormal protein aggregation in neurodegeneration
, 1999 Edward H. Koo +2 more
openalex +1 more source
Microglial activation precedes acute neurodegeneration in Sandhoff disease and is suppressed by bone marrow transplantation [PDF]
, 2000 Ryuichi Wada +2 more
openalex +1 more source
Advanced Science, EarlyView.This study identifies MTCH2 as a crucial regulator of ferroptosis in colorectal cancer (CRC) progression. High expression of MTCH2 is correlated with poor prognosis in CRC patients. Furthermore, MTCH2 depletion induces ferroptosis to suppress CRC liver metastasis via the E2F4/TFRC axis and sensitizes tumors to sorafenib treatment, supporting MTCH2 as a
Pu Xing +18 more
wiley +1 more source
NETs activate the GAS6-AXL-NLRP3 axis in macrophages to drive morphine tolerance
Cell Communication and SignalingBackground The development of morphine tolerance presents a major clinical challenge in the effective management of severe pain. This study aims to explore the mechanisms underlying morphine tolerance from a novel perspective, with the ultimate goal of ...
Qingyan Tian +10 more
doaj +1 more source
A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration [PDF]
, 2000 Jani Tyynelä
openalex +1 more source
Organization of the Proteostasis Network of Membraneless Organelles
Advanced Science, EarlyView.A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specificity and promiscuity within the PN. The findings suggest that HSP70 chaperones act as generic MLO regulators, while client specific HSP70 co‐chaperones may
Christine M. Lim +6 more
wiley +1 more source
β-Amyloid Peptides Are Cytotoxic to Astrocytes in Culture: A Role for Oxidative Stress
Neurobiology of Disease, 2000 β-Amyloid is cytotoxic to neurons in culture by increasing hydrogen peroxide and altering calcium homeostasis. We have evaluated the cytotoxicty of β-amyloid peptides (βA25–35 and βA1–40) and generation of hydrogen peroxide on cortical cultured ...
Begoña Brera +2 more
doaj
Advanced Science, EarlyView.We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich +8 more
wiley +1 more source