Results 81 to 90 of about 18,329 (223)

Co‐ and Multi‐Pathologies in Parkinson's Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review

Movement Disorders, EarlyView.
Abstract Parkinson's disease (PD) has been historically defined as a disease of striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra pars compacta, related to the presence of Lewy bodies and Lewy neurites.
Michele Matarazzo, Per Borghammer, Inas Elsayed, Jennifer G. Goldman, Yue Huang, Katja Lohmann, Per Svenningsson, Lorraine V. Kalia, Daniela Berg, Jeffrey H. Kordower, the MDS Scientific Issues Committee   +10 more
wiley   +1 more source

Seeing Invisible Oligomers: Rethinking α‐Synuclein Pathology Through Proximity Ligation Assay

Movement Disorders, EarlyView.
Abstract Parkinson's disease (PD) and multiple system atrophy are defined by α‐synuclein (αSYN)‐positive inclusions – Lewy bodies (LBs) and glial cytoplasmic inclusions – yet mounting evidence indicates that these inclusions represent only a fraction of disease‐relevant pathology.
Hiroaki Sekiya, Nanna Møller Jensen, Dennis W. Dickson, Poul Henning Jensen   +3 more
wiley   +1 more source

Mitochondrial membrane protein associated neurodegenration: a novel variant of neurodegeneration with brain iron accumulation.

, 2013
Recently, mutations in an open-reading frame on chromosome 19 (C19orf12) were identified as a novel genetic factor in neurodegeneration with brain iron accumulation (NBIA). Because of the mitochondrial localization of the derived protein, this variant is
Schulte, EC;Claussen, MC;Jochim, A;Haack, T;Hartig, M;Hempel, M;Prokisch, H;Haun-Jünger, U;Winkelmann, J;Hemmer, B;Förschler, A;Ilg, R
core   +2 more sources

Calibration of myocardial T2 and T1 against iron concentration. [PDF]

, 2014
BACKGROUND: The assessment of myocardial iron using T2* cardiovascular magnetic resonance (CMR) has been validated and calibrated, and is in clinical use.
Timothy G St. Pierre, St Pierre, TG, Firmin, DN, Forni, G, Mary N Sheppard, Fleming, A, Gualtiero Catani, He, T, Gianluca Forni, Taigang He, House, M, Sofia V de Noronha, Carpenter, JP, Black, G, Walker, J, Sheppard, MN, Kirk, P, Baksi, AJ, John C Wood, Porter, JB, John B Porter, Mike House, Walker, JM, Fucharoen, S, Wood, JC, Suthat Fucharoen, A John Baksi, Pennell, DJ, Adam Fleming, Greg Black, Anderson, LJ, Baksi, A, Dudley J Pennell, Paul Kirk, Lisa J Anderson, David N Firmin, John-Paul Carpenter, J Malcolm Walker, Gildo Matta, Michael Roughton, Roughton, M, de Noronha, SV, Matta, G, Catani, G   +43 more
core   +1 more source

Depletion of microglial compensation in glial network: Disease‐associated response dynamics in the revised amyloid hypothesis

Neuroprotection, EarlyView.
The critical transition from amyloid pathology to irreversible neuronal loss in Alzheimer's disease hinges on the microglial response. This review aims to systematize the patterns of how microglia react within the glial context. Abstract Microglia mount coordinated, stage‐dependent compensatory programs in response to early amyloid β (Aβ) accumulation ...
Songtao Lei, Zixuan Huang, Wen Wang, Yan Meng   +3 more
wiley   +1 more source

Mitochondrial membrane protein-associated neurodegeneration presenting with pure motor neuropathy: A rare case report and review of the literature

Annals of Movement Disorders
Neurodegeneration with brain iron accumulation is a collective term for neurodegenerative disorders characterized by excessive deposition of iron in the brain, especially in the globus pallidus and substantia nigra.
Vikas Lakhanpal, Sameer Peer, Ramandeep Singh, Bhawna Sharma   +3 more
doaj   +1 more source

Pantothenate kinase-2 (Pank2) silencing causes cell growth reduction, cell-specific ferroportin upregulation and iron deregulation

Neurobiology of Disease, 2010
Pantothenate kinase 2 (Pank2) is a mitochondrial enzyme that catalyses the first regulatory step of Coenzyme A synthesis and that is responsible for a genetic movement disorder named Pank-associated neurodegeneration (PKAN).
Maura Poli, Manuela Derosas, Sara Luscieti, Patrizia Cavadini, Alessandro Campanella, Rosanna Verardi, Dario Finazzi, Paolo Arosio   +7 more
doaj   +1 more source

Chapter 19 - Neurodegeneration with brain iron accumulation

, 2018
Neurodegeneration with brain iron accumulation (NBIA) comprises a clinically and genetically heterogeneous group of disorders affecting children and adults.
Kurian, MA, Hogarth, P, Hayflick, SJ
core  

Neuroprotective effects of ursodeoxycholic acid in Parkinson's disease and Alzheimer's disease

Neuroprotection, EarlyView.
In Parkinson's disease (PD) and Alzheimer's disease (AD), various shared pathological mechanisms exist. UDCA has been shown to exert neuroprotective effects in preclinical and clinical studies. Such effects include the mitigation of neuroinflammation as well as rescue effects on mitochondrial dysfunction, oxidative stress, impaired autophagy, and ...
Ashley En Yi Chong, Andrew Octavian Sasmita, Rhun Yian Koh, Anna Pick Kiong Ling   +3 more
wiley   +1 more source

Neurodegeneration with Brain Iron Accumulation in an Eleven-Year-Old Jamaican Male

Case Reports in Radiology, 2014
We present a case of an eleven-year-old boy presenting with progressive extrapyramidal signs and dementia. His imaging findings demonstrated the classic eye-of-the-tiger sign on T2W magnetic resonance imaging.
Peter Johnson, Roxanne Melbourne-Chambers, Nilesh Desai, Emma Greenaway   +3 more
doaj   +1 more source