Results 101 to 110 of about 9,496,868 (341)
NRF2 as a Therapeutic Target in Neurodegenerative Diseases
ASN Neuro, 2020 Increased reactive oxygen species production and oxidative stress have been implicated in the pathogenesis of numerous neurodegenerative conditions including among others Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Friedrich’s ataxia,
Mikah S. Brandes, Nora E. Gray
semanticscholar +1 more source
Protein Aggregates and Polyglutamine Tracts In Neurodegenerative Disease [PDF]
, 2018 The incidence of neurodegenerative diseases such as Alzheimer\u27s Disease, Parkinson\u27s Disease, Huntington\u27s Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of ...
Mack, John
core +1 more source
A survey and a molecular dynamics study on the (central) hydrophobic region of prion proteins
, 2014 Prion diseases are invariably fatal neurodegenerative diseases that affect humans and animals. Unlike most other amyloid forming neurodegenerative diseases, these can be highly infectious. Prion diseases occur in a variety of species.
Wang, Feng, Zhang, Jiapu
core +1 more source
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Aluminum and Neurodegenerative Disease
, 2017 This review assembles evidence derived from both epidemiological and laboratory studies that suggest exposure to aluminum salts may be more hazardous than generally recognized. The overview describes how available levels of environmental aluminum may be increasing, and it is suggested that this can have adverse health consequences.
Bondy, Stephen C, Campbell, Arezoo
openaire +3 more sources
Selenium, selenoproteins and neurodegenerative diseases [PDF]
, 2015 © The Royal Society of Chemistry 2015. It is unsurprising that our understanding of the role of selenium in neurological function is somewhat immature, considering its relatively recent discovery as an essential element to human health.
Bush, AI +3 more
core +3 more sources
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
The lysosome and neurodegenerative diseases [PDF]
Acta Biochimica et Biophysica Sinica, 2009 It has long been believed that the lysosome is an important digestive organelle. There is increasing evidence that the lysosome is also involved in pathogenesis of a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
Zheng-Hong Qin, Li-sha Zhang, Rui Sheng
openaire +3 more sources
Imaging Studies of Aging, Neurodegenerative Disease, and Alcoholism. [PDF]
, 1995 Neurodegenerative diseases such as Alzheimers disease, disorders such as alcoholism, and the aging process can lead to impaired cognitive function and dementia.
Eberling, Jamie, JAGUST, William J
core
Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source